Open Access

Chenyu Jiang, Hao Zhang^*
Congenital Heart Disease, Vol.20, No.2, pp. 129-131, 2025, DOI:10.32604/chd.2025.064155 - 30 April 2025
Abstract This article has no abstract. More >

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ARTICLE

Dina Anggraini¹, Kurnia Wahyudi², Melawati Hasan³, Sri Endah Rahayuningsih^4,*, Charlotte Johanna Cool³
Congenital Heart Disease, Vol.20, No.2, pp. 133-141, 2025, DOI:10.32604/chd.2025.064164 - 30 April 2025
Abstract Background: Congenital heart disease (CHD) occurs in 9 out of 100 births and is the leading cause of birth defects, with acyanotic CHD being more common. The incidence of adult CHD is rising faster than pediatric CHD. Pulmonary hypertension is the most common complication in untreated CHD patients. Methods: This study is retrospective descriptive research based on medical record data and the results of right heart catheterization examinations in adult acyanotic CHD aged ≥18 years and free from other organ disorders. Results: A total of 103 patients met the inclusion criteria, the majority were young… More >

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REVIEW

Baker M. Ayyash¹, Yen Chuan Chen², Ahmad Sallehuddin², Ziyad M. Hijazi^1,*
Congenital Heart Disease, Vol.20, No.2, pp. 143-179, 2025, DOI:10.32604/chd.2025.064599 - 30 April 2025
Abstract Pediatric heart valve replacement (PHVR) remains a challenging procedure due to the unique anatomical and physiological characteristics of children, including growth and development, as well as the long-term need for durable valve function. This review provides an overview of both surgical and transcatheter options for aortic, mitral, pulmonary, and tricuspid valve replacements in pediatric patients, highlighting the indications, outcomes, and advancements in technology and technique. Surgical valve replacement traditionally involves the implantation of biological or mechanical prosthetic valves, with biological valves being preferred in children to reduce the need for lifelong anticoagulation therapy. However, the… More >

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Su Ye¹, Luxi Guan¹, Dong Luo¹, Fengwen Zhang¹, Jianhua Lv¹, Qizong Xie², Qiao Huang², Haiming Wu², Haibo Hu^1,*, Xiangbing Pan^1,*
Congenital Heart Disease, Vol.20, No.2, pp. 181-193, 2025, DOI:10.32604/chd.2025.063297 - 30 April 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Objectives: This study aimed to evaluate the feasibility, safety, and efficacy of a novel transcatheter suture closure system (HaloStitch^®) for patent foramen ovale (PFO) closure in a swine model. Methods: Thirteen swine underwent experimental PFO model creation. All animals received implantation of the transcatheter suture closure system to evaluate procedural success. Comprehensive follow-up over six months included serial ultrasound imaging, histopathological analysis, and gross anatomical examination of cardiac specimens. Results: Successful HaloStitch^® device implantation was achieved in 11 of 13 swine. Gross anatomical examination confirmed secure positioning of all sutures in the atrial septum, with no redundancy or… More >

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LETTER

Yaqi Tang^1,#, Gang Luo^1,#, Huashu Liu², Hao Wan¹, Silin Pan^1,*
Congenital Heart Disease, Vol.20, No.2, pp. 195-200, 2025, DOI:10.32604/chd.2025.063682 - 30 April 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Congenital atrial septal defect (ASD) with severe scoliosis is a rare compound malformation in children. Severe scoliosis should be corrected as soon as possible. The growth rod is suitable for patients with early scoliosis and obvious scoliosis under 10 years old. However, the fluoroscopic radiopaque of titanium alloy plate will inevitably partly make the operative field of interventional occlusion blind. We present a 7-year-old Chinese girl with ASD and scoliosis who underwent spinal correction with a dual-growth rod. In this case, we performed transcatheter closure of ASD solely under the guidance of transthoracic echocardiography. Transthoracic More >

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ARTICLE

Jacob PL Ho¹, Carol WK Ng², Wilfred HS Wong³, Yiu-fai Cheung^1,3,*
Congenital Heart Disease, Vol.20, No.2, pp. 201-211, 2025, DOI:10.32604/chd.2025.063217 - 30 April 2025
Abstract Background: The role of cardiothoracic ratio (CTR) from the chest radiograph for assessment of ventricular enlargement and function in repaired tetralogy of Fallot (TOF) is conflicting. This study aimed to determine the associations between CTR and cardiac magnetic resonance (CMR)-derived ventricular volumes and indices of ventricular function in adolescents and young adults with repaired TOF. Methods: The CTR and CMR findings, performed within 12 months of each other, were reviewed in 76 patients aged 22.1 ± 6.4 years. Associations between CTR and CMR parameters including right (RV) and left ventricular (LV) volumes and ejection fraction were… More >

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ARTICLE

Jiawei Shi^1,2,3,#, Zhen Wang^1,2,3,#, Ying Bai^1,2,3, Shiying Li^1,2,3, Xin Zhang^1,2,3, Tianshu Liu^1,2,3, Liu Hong^1,2,3, Li Cui^1,2,3, Yi Zhang^1,2,3, Jing Ma^1,2,3, Juanjuan Liu^1,2,3, Jing Zhang^1,2,3, Haiyan Cao^1,2,3,*, Jing Wang^1,2,3,*
Congenital Heart Disease, Vol.20, No.2, pp. 213-229, 2025, DOI:10.32604/chd.2025.064950 - 30 April 2025
Abstract Background: Tetralogy of Fallot (TOF), the predominant cyanotic congenital heart defect, arises from multifactorial gene-environment interactions disrupting cardiac developmental networks. This study investigated TOF-specific transcriptional alterations and identified high-confidence candidate genes. Methods: Based on GSE36761 transcriptome data, a weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network were conducted to identify TOF-related sub-network and Hub genes. The potential biological functions among these genes were revealed by enrichment analysis. Genetic, epigenetic and transcriptional alteration in the Hub genes were analyzed with leveraged public resources: a methylation dataset (GSE62629) and two single-cell datasets (EGAS00001003996 and GSE126128). Results:… More >

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ARTICLE

Nuttanicha Sriboonyawattana^*, Thitima Suklerttrakul
Congenital Heart Disease, Vol.20, No.2, pp. 231-244, 2025, DOI:10.32604/chd.2025.064662 - 30 April 2025
Abstract Objective: Many children with fully corrected congenital heart disease (CHD) avoid physical activity (PA). This descriptive study sought to determine child and parental factors that could predict PA levels in Thai children after corrective surgery. Methods: Ninety school-aged children with fully corrected CHD were recruited from a cardiology clinic at a university hospital in northern Thailand. Data collection involved five validated questionnaires: (1) the Modified Thai Adolescent’s Physical Activity Questionnaire, (2) the Child Health Status Questionnaire-Forms I and II, (3) the Parental Knowledge on School-aged Children’s Physical Activity Scale, (4) the Perceived Self-efficacy to Physical Activity… More >

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REVIEW

Hongqun Xiang¹, Jian Zhuang^2,3, Luoning Bao^4,5, Yan Shi^2,3,*
Congenital Heart Disease, Vol.20, No.2, pp. 245-263, 2025, DOI:10.32604/chd.2025.064366 - 30 April 2025
Abstract Congenital heart disease (CHD) is the most common birth defect, with 34% of cases attributed to genetic variants. NOTCH1, a multi-domain transmembrane protein, regulates heart development by controlling the differentiation and migration of myocardial mesoderm cells, and different variants are present in different types of CHD. In this review, we aim to provide a detailed description of NOTCH1 structural domains and their functions, highlighting NOTCH1 variants in CHD and the molecular mechanisms through which they contribute to CHD occurrence. NOTCH1 has two main domains, the NOTCH extracellular domain (NECD) and the NOTCH intracellular domain… More >

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ARTICLE

Yuen Lo Yau¹, Matthew S. Purlee², Lindsey M. Brinkley², Dipankar Gupta¹, David M. Saulino³, Dalia Lopez-Colon¹, John-Anthony Coppola¹, Dhanashree Rajderkar⁴, Himesh Vyas^1,*
Congenital Heart Disease, Vol.20, No.2, pp. 265-272, 2025, DOI:10.32604/chd.2025.065661 - 30 April 2025
（This article belongs to the Special Issue: Novel Insights into Congenital Heart Disease: Pathophysiology, Biomarkers, and Future Directions)
Abstract Background: Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE. Methods: A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and… More >

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