Open Access

ARTICLE

A Deep Learning Approach for Prediction of Protein Secondary Structure

Muhammad Zubair¹, Muhammad Kashif Hanif^1,*, Eatedal Alabdulkreem², Yazeed Ghadi³, Muhammad Irfan Khan¹, Muhammad Umer Sarwar¹, Ayesha Hanif¹

1 Department of Computer Science, Government College University, Faisalabad, Pakistan
2 Department of Computer Science, College of Computer and Information Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
3 Department of Software Engineering/Computer Science, Al Ain University, Abu Dhabi, United Arab Emirates

* Corresponding Author: Muhammad Kashif Hanif. Email:

Computers, Materials & Continua 2022, 72(2), 3705-3718. https://doi.org/10.32604/cmc.2022.026408

Received 24 December 2021; Accepted 20 February 2022; Issue published 29 March 2022

Abstract

The secondary structure of a protein is critical for establishing a link between the protein primary and tertiary structures. For this reason, it is important to design methods for accurate protein secondary structure prediction. Most of the existing computational techniques for protein structural and functional prediction are based on machine learning with shallow frameworks. Different deep learning architectures have already been applied to tackle protein secondary structure prediction problem. In this study, deep learning based models, i.e., convolutional neural network and long short-term memory for protein secondary structure prediction were proposed. The input to proposed models is amino acid sequences which were derived from CulledPDB dataset. Hyperparameter tuning with cross validation was employed to attain best parameters for the proposed models. The proposed models enables effective processing of amino acids and attain approximately 87.05% and 87.47% Q₃ accuracy of protein secondary structure prediction for convolutional neural network and long short-term memory models, respectively.

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Keywords

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