Open Access


Combining Entropy Optimization and Sobel Operator for Medical Image Fusion

Nguyen Tu Trung1,*, Tran Thi Ngan1, Tran Manh Tuan1, To Huu Nguyen2
1 Faculty of Computer Science and Engineering, Thuyloi University, 175 Tay Son, Dong Da, Hanoi, 010000, Vietnam
2 University of Information and Communication Technology, Thai Nguyen University, Thai Nguyen, 240000, Vietnam
* Corresponding Author: Nguyen Tu Trung. Email:

Computer Systems Science and Engineering 2023, 44(1), 535-544.

Received 13 December 2021; Accepted 14 January 2022; Issue published 01 June 2022


Fusing medical images is a topic of interest in processing medical images. This is achieved to through fusing information from multimodality images for the purpose of increasing the clinical diagnosis accuracy. This fusion aims to improve the image quality and preserve the specific features. The methods of medical image fusion generally use knowledge in many different fields such as clinical medicine, computer vision, digital imaging, machine learning, pattern recognition to fuse different medical images. There are two main approaches in fusing image, including spatial domain approach and transform domain approachs. This paper proposes a new algorithm to fusion multimodal images. This algorithm is based on Entropy optimization and the Sobel operator. Wavelet transform is used to split the input images into components over the low and high frequency domains. Then, two fusion rules are used for obtaining the fusing images. The first rule, based on the Sobel operator, is used for high frequency components. The second rule, based on Entropy optimization by using Particle Swarm Optimization (PSO) algorithm, is used for low frequency components. Proposed algorithm is implemented on the images related to central nervous system diseases. The experimental results of the paper show that the proposed algorithm is better than some recent methods in term of brightness level, the contrast, the entropy, the gradient and visual information fidelity for fusion (VIFF), Feature Mutual Information (FMI) indices.


Medical image fusion; wavelet; entropy optimization; PSO; Sobel operator

Cite This Article

N. Tu Trung, T. Thi Ngan, T. Manh Tuan and T. Huu Nguyen, "Combining entropy optimization and sobel operator for medical image fusion," Computer Systems Science and Engineering, vol. 44, no.1, pp. 535–544, 2023.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 720


  • 284


  • 0


Share Link

WeChat scan