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Hydrogels with Brain Tissue-Like Mechanical Properties in Complex Environments
Jingyu Wang1,#, Yongrou Zhang4,#, Zuyue Lei1, Junqi Wang1, Yangming Zhao1, Taolin Sun3,*, Zhenyu Jiang1, Licheng Zhou1, Zejia Liu1, Yiping Liu1, Bao Yang1, Liqun Tang1,2,*
1 School of Civil Engineering and Transportation, South China University of Technology, No.381, Wushan Road, Guangzhou,
510641, China
2 State Key Laboratory of Subtropical Building Science, South China University of Technology, No.381, Wushan Road,
Guangzhou, 510641, China
3 School of Emergent Soft Matter, South China University of Technology, No.381, Wushan Road, Guangzhou, 510641, China
4 Department of Applied Mechanics and Engineering, School of Aeronautics and Astronautics, Sun Yat-sen University,
No.135, Xingangxi Road, Guangzhou 510275, China
* Corresponding Authors: Liqun Tang. Email: ; Taolin Sun. Email: .
# Co-first Author
The International Conference on Computational & Experimental Engineering and Sciences 2023, 25(4), 1-1. https://doi.org/10.32604/icces.2022.08829
Abstract
In surgical training applications and experimental research, brain tissues immersed in cerebrospinal fluid
often involve very complex deformation and strain rate effects, which affects their reliability and stability.
Thus, it is indispensable to develop a high-fidelity human brain tissue simulant material as a physical
surrogate model to understand their mechanical behavior, such as traumatic brain injury (TBI). However,
the reported simulant materials have not yet been able to compare and satisfy the above two mechanical
properties. Here, we developed a novel composite hydrogel with brain tissue-like mechanical properties and
investigated their mechanical behavior in a solution environment. The results demonstrate that this
composite hydrogel shows some common features with fresh porcine brain tissue, such as nonlinear
mechanical behavior and a good similarity under various external environments (artificial cerebrospinal
fluid, saline solution, deionized water, and air environments) and strain rates (0.001s-1,900s-1,1700s-1).
Furthermore, using a life-sized brain tissue mold, we successfully constructed a 3D brain-like tissue model
based on this composite hydrogel, which validates the feasibility of surgical training on this model. Since the
properties of human brain tissue are similar to those of porcine brain tissue, our work will have important
reference value for the realization of surgical training and related research in biomedical engineering.
Keywords
Cite This Article
APA Style
Wang, J., Zhang, Y., Lei, Z., Wang, J., Zhao, Y. et al. (2023). Hydrogels with brain tissue-like mechanical properties in complex environments. The International Conference on Computational & Experimental Engineering and Sciences, 25(4), 1-1. https://doi.org/10.32604/icces.2022.08829
Vancouver Style
Wang J, Zhang Y, Lei Z, Wang J, Zhao Y, Sun T, et al. Hydrogels with brain tissue-like mechanical properties in complex environments. Int Conf Comput Exp Eng Sciences . 2023;25(4):1-1 https://doi.org/10.32604/icces.2022.08829
IEEE Style
J. Wang et al., "Hydrogels with Brain Tissue-Like Mechanical Properties in Complex Environments," Int. Conf. Comput. Exp. Eng. Sciences , vol. 25, no. 4, pp. 1-1. 2023. https://doi.org/10.32604/icces.2022.08829