Open Access
ARTICLE
Bioactivity of Nanohybrid: Comprising of Metallosalen Incorporated into Lacunary Polyoxometalate and Encapsulated with Chitosan Biopolymer
SHIVA ARUNa, VINAY KUMAR SINGHa,#, PRABHA BHARTIYAb, PRADIP KUMAR DUTTAc,*
a
Department of Chemistry, Dr. Shakuntala Misra National Rehabilitation University,
Lucknow-226017, India.
b
Department of Chemistry, Sant Ganinath Government PG College, Muhammadabad Gohna,
Mau-276403, India.
c
Department of Chemistry, Motilal Nehru National Institute of Technology Allahabad,
Prayagraj-211004, India.
#
Present Address: Department of Chemistry, University of Lucknow-226007, India.
* Corresponding Author: e-mail:
Journal of Polymer Materials 2023, 40(1-2), 19-31. https://doi.org/10.32381/JPM.2023.40.1-2.2
Abstract
Biocompatible polymer chitosan has note-worthy applications in biomedical science. Nanohybrids
synthesized by using chitosan as an encapsulating unit for polyoxometalates (POMs) and
study of its biomedical applications is a fast-emerging field. In this research work, a lacunary
polyoxometalate (α-K
8SiW
11O
39) has been synthesized and then alkylsilane has been inserted
into its lacunary position. It has been then reacted with 2-hydroxy-1-naphtaldehyde followed by
copper metalation and finally encapsulated into chitosan by using the ionotropic gelation
technique, in which the chitosan and the POM served as cation and anion, respectively. The
bands in UV-Vis spectra at characteristic wavelength indicate that the organosilane is successfully
inserted into α-K
8SiW
11O
39 and metalled with Cu. Then its encapsulation into chitosan to
synthesize final nanohybrid has been confirmed by UV-Vis spectra. Further, chitosan, POM
inserted with organosilane and nanohybrid have been characterized by FT-IR. EDX analysis
reveals the presence of all the expected elements in their desired ratios. EDX study was further
supported by Inductively Coupled Plasma (ICP) technique. Morphology of nanohybrid has been
studied by Scanning Electron Microscope (SEM) imaging. The loading and entrapment efficiency of the prepared nanohybrid was exceptionally excellent and was calculated to be 81.2% and
59.1%, respectively. In vitro drug release study suggested sustainable and pH-modulated release
behaviour of the nanohybrid. Further, it is the first time that an organosilane attached to lacunary
POM, then metalated with Cu and finally encapsulated into CS has been investigated for drug
delivery. The antibacterial activity of POM inserted with organosilane and nanohybrid have been
tested against bacterial strains of B. subtilis gram (+)ve and E. coli gram (-)ve. The antibacterial
activity of nanohybrid has been improved as compared to bare POM inserted with metallated
organosilane and chitosan.
Keywords
Cite This Article
APA Style
ARUN, S., SINGH, V.K., BHARTIYA, P., DUTTA, P.K. (2023). Bioactivity of nanohybrid: comprising of metallosalen incorporated into lacunary polyoxometalate and encapsulated with chitosan biopolymer. Journal of Polymer Materials, 40(1-2), 19-31. https://doi.org/10.32381/JPM.2023.40.1-2.2
Vancouver Style
ARUN S, SINGH VK, BHARTIYA P, DUTTA PK. Bioactivity of nanohybrid: comprising of metallosalen incorporated into lacunary polyoxometalate and encapsulated with chitosan biopolymer. J Polym Materials . 2023;40(1-2):19-31 https://doi.org/10.32381/JPM.2023.40.1-2.2
IEEE Style
S. ARUN, V.K. SINGH, P. BHARTIYA, and P.K. DUTTA "Bioactivity of Nanohybrid: Comprising of Metallosalen Incorporated into Lacunary Polyoxometalate and Encapsulated with Chitosan Biopolymer," J. Polym. Materials , vol. 40, no. 1-2, pp. 19-31. 2023. https://doi.org/10.32381/JPM.2023.40.1-2.2