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Protein Secondary Structure Prediction with Dynamic Self-Adaptation Combination Strategy Based on Entropy

Yuehan Du1,2, Ruoyu Zhang1, Xu Zhang1, Antai Ouyang3, Xiaodong Zhang4, Jinyong Cheng1, Wenpeng Lu1,*

School of Computer, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Shandong Mental Health Center, Jinan, 250014, China.
School of Computer Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.
Jinan Intellectual Property Information Center, Jinan, 250099, China.

*Corresponding Author: Wenpeng Lu. Email: email.

Journal of Quantum Computing 2019, 1(1), 21-28.


The algorithm based on combination learning usually is superior to a single classification algorithm on the task of protein secondary structure prediction. However, the assignment of the weight of the base classifier usually lacks decision-making evidence. In this paper, we propose a protein secondary structure prediction method with dynamic self-adaptation combination strategy based on entropy, where the weights are assigned according to the entropy of posterior probabilities outputted by base classifiers. The higher entropy value means a lower weight for the base classifier. The final structure prediction is decided by the weighted combination of posterior probabilities. Extensive experiments on CB513 dataset demonstrates that the proposed method outperforms the existing methods, which can effectively improve the prediction performance.


Cite This Article

Y. Du, R. Zhang, X. Zhang, A. Ouyang, X. Zhang et al., "Protein secondary structure prediction with dynamic self-adaptation combination strategy based on entropy," Journal of Quantum Computing, vol. 1, no.1, pp. 21–28, 2019.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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