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Healing Effect and Underlying Mechanism of Silver Nanoparticles Prepared Using Carboxymethyl Chitosan under Solar Irradiation

Yi Long1,#,* , Chunling Zhang2,#,*, Lan Chen3,#, Tietao Di2, Lu Chen2, Lisha Tang2, Kaizhong Luo2, Yu Yan1, Pingzhen Tong2, Jie Xiang4

1 College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China
2 Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China
3 Department of environmental monitoring, Changsha Environmental Protection College, Changsha, 410004, China
4 Guizhou provincial Center For Disease Control And Prevention, Guiyang, 550004, China

* Corresponding Authors: Yi Long. Email: ; Chunling Zhang. Email:
# These authors contributed equally to this work

(This article belongs to this Special Issue: Current Advances in Green Nanomaterials Applications)

Journal of Renewable Materials 2021, 9(6), 1075-1085.


In our previous study, silver nanoparticles were prepared using AgNO3 and carboxymethyl chitosan (CMCS) which is commercially available with solar irradiation. In this study, the efficacy and safety of silver nanoparticles prepared by this method were evaluated for healing wounds in rats with diabetes. We also attempted to determine the underlying mechanism and influencing factors of the silver nanomaterial preparation method. Compared with growth factors, silver nanoparticles exhibit better healing effects for rats with diabetes. No remnant silver ions were detected in the major organs of these rats after the application of silver nanoparticles. Silver nanoparticles prepared using CMCS are less toxic than those prepared from the conventional method, promote the proliferation of skin fibroblasts, and are promising as a topical medication for infected wounds. An obvious breakage process of the particles is observed during the growth of nanocrystalline silver in CMCS. In this study, we also attempted to determine whether this method is suitable for synthesizing silver nanoparticles using N-trimethyl chitosan chloride and sodium alginate were used in this particular experiment. The characteristic UV-vis absorbance peak of silver nanoparticles was found only in the reaction mixture containing N-trimethyl chitosan chloride. Our study demonstrates that free radicals are the key factor in this silver nanoparticle preparation method.


Cite This Article

Long, Y., Chen, L., Di, T., Chen, L., Tang, L. et al. (2021). Healing Effect and Underlying Mechanism of Silver Nanoparticles Prepared Using Carboxymethyl Chitosan under Solar Irradiation. Journal of Renewable Materials, 9(6), 1075–1085.


This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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