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Encapsulation of Pt-labelled DNA Molecules inside Carbon Nanotubes

Daxiang Cui1, Cengiz S. Ozkan2, Sathyajith Ravindran3, Yong Kong1, Huajian Gao1

Max Planck Institute for Metals Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany
Department of Mechanical Engineering
Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521-0425, USA

Molecular & Cellular Biomechanics 2004, 1(2), 113-122.


Experiments on encapsulating Pt--labelled DNA molecules inside multiwalled carbon nanotubes (MWCNT) were performed under temperature and pressure conditions of 400K and 3 Bar. The DNA-CNT hybrids were purified via agarose gel electrophoresis and analyzed via high resolution transmission electron microscopy (HR-TEM) and energy dispersive X-ray spectroscopy (EDX). The results showed that the Pt-labelled DNA molecules attached to the outside walls of CNTs could be removed by electrophoresis. The HR-TEM and EDX results demonstrated that 2-3% of the Pt-labelled DNA molecules were successfully encapsulated inside the MWCNTs. The experimental study complements our previous molecular dynamics simulations on encapsulation of single stranded DNA oligonucleotides inside single wall carbon nanotubes under similar conditions in water. The van der Waals interaction between CNT and Pt-labelled DNA is believed to be the main driving force for this phenomenon. The DNA-CNT molecular complex could be further explored for potential applications in bio-nanotechnology.

Cite This Article

Cui, D., Ozkan, C. S., Ravindran, S., Kong, Y., Gao, H. (2004). Encapsulation of Pt-labelled DNA Molecules inside Carbon Nanotubes. Molecular & Cellular Biomechanics, 1(2), 113–122.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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