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Stretching Short DNAs in Electrolytes

Jizeng Wang1,2, Xiaojun Fan2, Huajian Gao2

E-mail: jz.wang@mf.mpg.de
Max Planck Institute for Metals Research, Heisenbergstrasse 3, D-70569 Stuttgart, Germany.

Molecular & Cellular Biomechanics 2006, 3(1), 13-20. https://doi.org/10.3970/mcb.2006.003.013


This paper is aimed at a combined theoretical and numerical study of the force-extension relation of a short DNA molecule stretched in an electrolyte. A theoretical formula based on a recent discrete wormlike chain (WLC) model of Kierfeld et al. (Eur. Phys. J. E, Vol. 14, pp.17-34, 2004) and the classical OSF mean-field theory on electrostatic stiffening of a charged polymer is numerically verified by a set of Brownian dynamics simulations based on a generalized bead-rod (GBR) model incorporating long-ranged electrostatic interactions via the Debye-Hueckel potential (DH). The analysis indicates that the stretching of a short DNA can be well described as a WLC with a constant effective persistent length. This contrasts the behavior of long DNA chains that are known to exhibit variable persistent lengths depending on the ion concentration levels and force magnitudes.

Cite This Article

APA Style
Wang, J., Fan, X., Gao, H. (2006). Stretching short dnas in electrolytes. Molecular & Cellular Biomechanics, 3(1), 13-20. https://doi.org/10.3970/mcb.2006.003.013
Vancouver Style
Wang J, Fan X, Gao H. Stretching short dnas in electrolytes. Mol Cellular Biomechanics . 2006;3(1):13-20 https://doi.org/10.3970/mcb.2006.003.013
IEEE Style
J. Wang, X. Fan, and H. Gao "Stretching Short DNAs in Electrolytes," Mol. Cellular Biomechanics , vol. 3, no. 1, pp. 13-20. 2006. https://doi.org/10.3970/mcb.2006.003.013

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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