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Optimal Substrate Shape for Vesicle Adhesion on a Curved Substrate

Wendong Shi∗,†, Xi-Qiao Feng*, Huajian Gao

* Department of Engineering Mechanics, Tsinghua University, Beijing 100084, P.R. China
Division of Engineering, Brown University, 182 Hope Street, Providence, RI 02912

Molecular & Cellular Biomechanics 2006, 3(3), 121-126. https://doi.org/10.3970/mcb.2006.003.121

Abstract

When pulling a vesicle adhered on a substrate, both the force-displacement profile and the maximum force at pull-off are sensitively dependent upon the substrate shape. Here we consider the adhesion between a two-dimensional vesicle and a rigid substrate via long-range molecular interactions. For a given contact area, the theoretical pull-off force of the vesicle is obtained by multiplying the theoretical strength of adhesion and the contact area. It is shown that one may design an optimal substrate shape to achieve the theoretical pull-off force.

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Shi, W., Feng, X., Gao, H. (2006). Optimal Substrate Shape for Vesicle Adhesion on a Curved Substrate. Molecular & Cellular Biomechanics, 3(3), 121–126.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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