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Elastic Laminae in Vascular Development and Disease

Shu Q. Liu∗,†, Brandon J. Teft*, Li-Qun Zhang, Yan Chun Li§, Yu H. Wu*

Biomedical Engineering Department, Northwestern University, Evanston, IL 60208
Corresponding author. Phone: 847 491 5745; E-mail: sliu@northwestern.edu
Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611
§ Department of Medicine, The University of Chicago, Chicago, IL 60637

Molecular & Cellular Biomechanics 2010, 7(2), 59-76. https://doi.org/10.3970/mcb.2010.007.059

Abstract

The activities of vascular cells, including adhesion, proliferation, and migration, are mediated by extracellular matrix components, including collagen matrix and elastic fibers or laminae. Whereas the collagen matrix stimulates vascular cell adhesion, proliferation, and migration, the elastic laminae inhibit these activities. Coordinated regulation of cell activities by these matrix components is an essential process for controlling the development and remodeling of the vascular system. This article summarizes recent development on the role of arterial elastic laminae in regulating the development of smooth muscle-like cells from bone marrow-derived progenitor cells as well as in mediating cell adhesion, proliferation, and migration with a focus on the molecular mechanisms and physiological significance.

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APA Style
Liu, S.Q., Teft, B.J., Zhang, L., Li, Y.C., Wu, Y.H. (2010). Elastic laminae in vascular development and disease. Molecular & Cellular Biomechanics, 7(2), 59-76. https://doi.org/10.3970/mcb.2010.007.059
Vancouver Style
Liu SQ, Teft BJ, Zhang L, Li YC, Wu YH. Elastic laminae in vascular development and disease. Mol Cellular Biomechanics . 2010;7(2):59-76 https://doi.org/10.3970/mcb.2010.007.059
IEEE Style
S.Q. Liu, B.J. Teft, L. Zhang, Y.C. Li, and Y.H. Wu "Elastic Laminae in Vascular Development and Disease," Mol. Cellular Biomechanics , vol. 7, no. 2, pp. 59-76. 2010. https://doi.org/10.3970/mcb.2010.007.059



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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