Open Access
ARTICLE
Effects of Dexmedetomidine Combined with Remifentanil Anesthesia and Propofol Combined with Remifentanil Anesthesia on Perioperative Inflammatory Response and Pulmonary Function in Patients with Lung Cancer
Siqiang Tian1,#, Yao Jiang2,#, Ying Wang1, Jie Song1,*
1 Department of Respiratory, Zaozhuang Hospital of Traditional Chinese Medicine, Zaozhuang, China
2 Department of Pharmaceutical, Zaozhuang Mining Group Central Hospital, Zaozhuang, China
# Siqiang Tian and Yao Jiang have the same contribution to this study
* Corresponding Author: Jie Song. Email:
Oncologie 2020, 22(1), 13-21. https://doi.org/10.32604/oncologie.2020.012492
Abstract
To explore the effects of dexmedetomidine combined with remifentanil
anesthesia and propofol combined with remifentanil anesthesia on perioperative
inflammatory response and pulmonary function in patients with lung cancer. Totally
128 patients admitted to our hospital for lung cancer surgery were taken as the
research object of this experiment. Among them, 67 cases were sedated with
dexmedetomidine combined with remifentanil (Group A), and 61 cases were sedated
with propofol combined with remifentanil (Group B). The changes of vital signs,
respiratory interval (RR), blood oxygen saturation (SpO2) and blood sugar before
and after sedation were recorded. The changes of inflammatory factors TNF-α, IL-
6, IL-10, pulmonary function indexes FEV1, FVC, FEV1/FVC in the two groups at
24 hours after sedation were observed. Hemodynamic heart rate (HR), mean arterial
pressure (MAP) and other indexes before and after sedation were observed. VAS
pain score and MMSE score before and after sedation were compared between the
two groups. The incidence of adverse reactions after sedation was observed in the
two groups. The decrease of RR and SpO2 in Group B was more remarkable than
that in Group A (
p < 0.05). The elevation of blood sugar in Group A was lower than
that in Group B (
p < 0.05). Group A had lower levels of TNF-α and IL-6 and higher
level of IL-10 (
p < 0.05), and higher expression of FEV1, FVC and FEV1/FVC when
compared with Group B (
p < 0.05). The decrease of HR and MAP in Group B was
greater than that in Group A (
p < 0.05). VAS score was lower in Group A than Group
B (
p < 0.05), and MMSE score was higher in Group A than Group B (
p < 0.05). The
incidence of adverse reactions in Group A was lower than that in Group B,
p < 0.05.
Compared with propofol, dexmedetomidine combined with remifentanil anesthesia
is more effective in improving postoperative inflammatory factors and pulmonary
function of lung cancer patients, which is worthier of recommendation.
Keywords
Cite This Article
Tian, S., Jiang, Y., Wang, Y., Song, J. (2020). Effects of Dexmedetomidine Combined with Remifentanil Anesthesia and Propofol Combined with Remifentanil Anesthesia on Perioperative Inflammatory Response and Pulmonary Function in Patients with Lung Cancer.
Oncologie, 22(1), 13–21.
Citations