Open Access
ARTICLE
Effects of Ulinastatin Combined with Dexmedetomidine on Postoperative Cognitive Function and Central Nerve Specific Protein Level in Elderly Colorectal Cancer Patients after Laparoscopic
Li Bao1, Xiaowei Tian2, Jing Zhang3, Li Chen4, Kui Gao5,*
1 Nutrition Department, Wuhan Mental Health Center, Wuhan, 430012, China
2 Department of Brain Rehabilitation, Zaozhuang City Hospital of Traditional Chinese Medicine, Zaozhuang, 277100, China
3 Clinical Laboratory, Wuhan Mental Health Center, Wuhan, 430012, China
4 Mental Trauma Ward, Wuhan Mental Health Center, Wuhan, 430012, China
5 The 17th Ward, Wuhan Mental Health Center, Wuhan, 430012, China
* Corresponding Author: Kui Gao. Email:
Oncologie 2020, 22(3), 167-178. https://doi.org/10.32604/oncologie.2020.012495
Abstract
Ulinastatin combined with dexmedetomidine can improve
postoperative cognitive function and central nerve specific protein (S-100β) level
in elderly colorectal cancer (CC) patients after laparoscopic. Altogether 178
elderly patients who underwent laparoscopic colorectal cancer surgery in our
hospital from February 2018 to August 2019 were selected and divided into two
groups according to the treatment methods. Those anesthetized by
dexmedetomidine were regarded as the routine group (RG, 83 cases), and those
anesthetized by ulinastatin and dexmedetomidine were considered as the
combined group (CG, 95 cases). The operation conditions of the two groups, the
pain scores (VAS) at 4 h, 24 h and 48 h after surgery, and the MMSE scores before,
1 d and 3 d after surgery were recorded. The incidence of cognitive dysfunction
and adverse reactions were compared between both groups. The serum S-100β
protein (S-100β) and inflammatory factors were detected by enzyme-linked
immunosorbent assay (ELISA). The risk factors of postoperative cognitive
dysfunction (POCD) were analyzed. The eye-opening time of clinical indexes in
the CG was dramatically lower than in the RG, while other indexes had no marked
difference. The VAS scores of the CG were lower than those of the RG at 4 h, 24
h and 48 h after operation. The MMSE scores of patients in the CG were
dramatically higher than those in the RG at 1 d and 3 d after surgery. The total
incidence of POCD in the CG was lower than that in the RG. There was no
remarkable difference in the total incidence of adverse reactions between both
groups. The S-100β expression level in the CG was dramatically lower than in the
RG at 1 d and 3 d after surgery. The improvement level of inflammatory factors
in the CG was dramatically better than that in the RG. Multivariate Logistic
regression analysis identified that the eye-opening time, VAS score, IL-10, TNF-
α, CRP, and S-100β were independent risk factors for POCD occurrence in elderly
CC patients after surgery. Ulinastatin combined with dexmedetomidine anesthesia
induction can improve the prognosis of elderly CC patients after laparoscopic and
it also reduces postoperative pain and serum inflammatory factors. S-100β
concentration can improve the POCD occurrence after surgery.
Keywords
Cite This Article
Bao, L., Tian, X., Zhang, J., Chen, L., Gao, K. (2020). Effects of Ulinastatin Combined with Dexmedetomidine on Postoperative Cognitive Function and Central Nerve Specific Protein Level in Elderly Colorectal Cancer Patients after Laparoscopic.
Oncologie, 22(3), 167–178.