Open Access iconOpen Access

ARTICLE

crossmark

Comprehensive Network Analysis of the Molecular Regulation Mechanism for Breast Cancer Metastasis

Shaoguan Huang1, Rong Zhang2, Lizhen Liu3,*

1 Emergency Internal Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China
2 Oncology Department, Jiading Hospital of Traditional Chinese Medicine, Shanghai, 201800, China
3 Oncology Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China

* Corresponding Author: Lizhen Liu. Email: email

Oncologie 2021, 23(1), 159-171. https://doi.org/10.32604/Oncologie.2021.012489

Abstract

Breast cancer is one of malignant severe diseases that cause cancer death in women. Although research about the pathogenesis and studies about treatment mechanisms in breast cancer have become clear focuses, we have no clear conclusion yet. Therefore, this research is based on a modular approach to explore key factors and molecular mechanisms that affect breast cancer metastasis. First of all, it is necessary to download breast cancer-related data on the GEO database, and we analyzed the difference between primary tumors and metastatic lesions to obtain differential gene expression profiles. On this basis, a series of bioinformatics analyses were performed to comprehensively, and they were presented to identify critical regulators in breast cancer metastasis. We have obtained a total of five co-expression modules, among which HECW1, FBN1, and other genes have effective regulation in dysfunction modules, and thus they would be recognized as driving genes for breast cancer metastasis. Module genes were significantly enriched in biological function, for instance, leukocyte-cell adhesion and negative regulation in the immune system process. At the same time, it substantially regulates signaling pathways, for example, fatty acid degradation, synthesis, and degradation of ketone bodies, and amino acid metabolism. Finally, we identified ncRNA pivots (including FENDRR, miR-19a-3p, and miR-26b-5p) and TF pivot (including NFKB1 and SP1) to regulate dysfunction modules significantly. Our study identified the coexpression network of genes involved in breast cancer metastasis. These results may be helpful to reveal the gene modules and regulatory factors of breast cancer. Importantly, we identified a long non-coding FENDRR that inhibits breast cancer metastasis through a fatty acid degradation signaling pathway, providing new directions and targets for subsequent studies.

Keywords


Supplementary Material

Supplementary Material File

Cite This Article

Huang, S., Zhang, R., Liu, L. (2021). Comprehensive Network Analysis of the Molecular Regulation Mechanism for Breast Cancer Metastasis. Oncologie, 23(1), 159–171.

Citations




cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2156

    View

  • 1205

    Download

  • 1

    Like

Share Link