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EDITORIAL

Jean-Philippe Metges^1,*, Daniel Serin², Xavier Troussard^3,4,5, Jean-Yves Blay⁶, Mario Campone⁷, Nicolas Isambert⁸, Tristan Montier^9,10, Nadine Houédé^11,12, Denis Frank¹³
Oncologie, Vol.23, No.1, pp. 1-2, 2021, DOI:10.32604/Oncologie.2021.016042
Abstract This article has no abstract. More >

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Thierry Levy^1,*, Joël Castelli², Morgane Kermarrec³, Jean-Philippe Metges⁴
Oncologie, Vol.23, No.1, pp. 3-38, 2021, DOI:10.32604/Oncologie.2021.016041
Abstract Introduction. -Depuis plusieurs siècles, les scientifiques comme Avicenne essaient de comprendre les processus de propagation des épidémies. Les consignes d'isolement sont apparues pendant la peste noire. Les magistrats et gestionnaires de crises gèrent la protection de toutes les populations. De nos jours, les agences régionales de santé régulent l’offre de soins y compris en période de crise sanitaire. Méthodes. -La mise en place du comité régional COVID et Cancer organisé et animé par l’Agence Régionale de Santé Bretagne et le réseau régional de cancérologie Oncobretagne, permet les échanges entre les professionnels de santé en oncologie. Ce… More >

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ARTICLE

Delphine Déniel Lagadec^1,2,*, Laurence Guen^1,2, Fabienne Le Goc Le Sager¹, Sandrine Estivin^1,3, Christophe Perrin^1,4
Oncologie, Vol.23, No.1, pp. 39-46, 2021, DOI:10.32604/Oncologie.2021.015985
Abstract Depuis mars 2020, l’épidémie de la COVID-19 impacte la prise en charge des patients dans le secteur de l’oncologie/hématologie dans les établissements de santé publics et privés. L’Unité de Coordination en Onco-Gériatrie région Bretagne a initié une enquête auprès des spécialistes en cancérologie afin de faire un état des lieux sur la prise en charge des patients atteints de cancer et âgés de plus de 75 ans dans la région. L’enquête a étéréalisée courant octobre 2020, post premier confinement, auprès de 24 spécialistes. 67% des spécialistes ont le sentiment de manquer de consignes claires/protocoles institutionnels More >

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REVIEW

Pierre-Guillaume Poureau^1,2,*, Jean-Philippe Metges²
Oncologie, Vol.23, No.1, pp. 47-59, 2021, DOI:10.32604/Oncologie.2021.15525
Abstract L’immunothérapie des cancers digestifs est en plein essor et pour la première fois un inhibiteur de point de contrôle immunitaire a obtenu une autorisation de mise sur le marché pour le traitement d’un cancer digestif. Afin d’appréhender au mieux le mécanisme d’action de ces traitements, leurs effets secondaires et l’échappement à ces traitement, il est nécessaire de connaître les fondamentaux de l’immunologie des cancers. Le système immunitaire inné et adaptatif permet l’élimination des cellules cancéreuses par cytotoxicité directe non spécifique (cellules Natural Killer), par le développement d’une réponse adaptative à médiation cellulaire (cellules dendritiques devenant… More >

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Yuan Liu^1,2,#, Yun Jia³, Bing Zhang², Anwen Liu^1,*
Oncologie, Vol.23, No.1, pp. 61-72, 2021, DOI:10.32604/Oncologie.2021.015906
Abstract Gastric cancer (GC) is the most common digestive system malignant tumor and second most common cause of cancer-related death. Even for the early gastric cancer, after radical operation, perioperative and postoperative chemotherapy the recurrence and metastasis are also high. 5-year overall survival of all GC patients is only 10–15%. Chemo-resistance still poses a major obstacle to successful treatment of GC. The aberrant expression of TUG1 (Taurine Upregulated Gene 1) was closely related to chemo-resistance and metastasis in many cancers. Here we over-expressed TUG1 in GC cell line SGC-7901 and MGC-803. We compared the migration ability More >

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REVIEW

Afiqah Halim¹, Wan Azani Mustafa^1,2,*, Wan Khairunizam Wan Ahmad¹, Hasliza A. Rahim², Hamzah Sakeran³
Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154
Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The… More >

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Shivangi Goyal, Sreemoyee Chatterjee, Nidhi Gupta^*
Oncologie, Vol.23, No.1, pp. 89-104, 2021, DOI:10.32604/Oncologie.2021.015234
Abstract Background: Trigonella foenum-graecum Linn. has been extensively used for medicinal purposes. The current study deals with in vitro and in vivo correlation of free radical quenching activity and anticancer potential of seed extracts of Trigonella. Materials and methods: Antioxidant activity was evaluated against DPPH, NO and ABTS via in vitro radical scavenging assay. Cytotoxicity effect of Trigonella seed extract was studied in human embryonic kidney HEK 293 cell line by alamar blue assay. In vivo antioxidant activity in Swiss albino mice model was assessed by studying endogenous antioxidant enzymes such as GSH, GPx, SOD and LPO. Antitumor effect was observed by studying parameters… More >

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1248

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Erkan Arslan^1,*, Ismail Koyuncu²
Oncologie, Vol.23, No.1, pp. 105-117, 2021, DOI:10.32604/Oncologie.2021.014764
Abstract Prostate cancer is the second most common cancer in men. Prostate-specific antigen (PSA) levels, commonly used in the diagnosis of prostate cancer, are increased in both malign and benign conditions, such as prostate hyperplasia (BPH) and prostatitis. Thus, more specific markers are urgently needed to discriminate between prostate cancer and benign diseases of the prostate. The purpose of this study is to examine both the intracellular and extracellular free amino acid profiles of metastatic prostate cancer cells (PC-3), normal prostate cells (PNT-1A), and metabolic changes (e.g., pH). In this study, cancer and normal cells were… More >

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1149

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Xin Chang^1,2,#,*, Jin Wang^2,#, Caifang Ni¹
Oncologie, Vol.23, No.1, pp. 119-130, 2021, DOI:10.32604/oncologie.2021.014152
Abstract Objective: This research was designed to observe the value of miR-1271 and GPC3 in evaluating the prognosis of liver cancer (LC) patients after liver transarterial chemoembolization (TACE). Methods: A total of 80 patients diagnosed as LC in our hospital from January 2018 to April 2019 were included in the LC group (LCG), and then assigned into a survival group (SG) and a death group (DG) based on prognosis. Seventy healthy subjects undergoing physical examination simultaneously were included in the normal group (NG). miR-1271 and GPC3 in serum of two groups of subjects were tested via qRT-PCR.… More >

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Fei Han¹, Jianghong Qu², Fengyue Li¹, Dapeng Zhang³, Jiangming Qu⁴, Guanghua Li^5,*
Oncologie, Vol.23, No.1, pp. 131-140, 2021, DOI:10.32604/Oncologie.2021.014153
Abstract Aim: This study aims to explore the role of serum long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) as a diagnostic marker for gastric cancer (GC). Methods: We recruited 76 patients with GC admitted to our hospital (the observation group, OG) and 83 healthy volunteers undergoing physical examinations during the same period (the control group, CG). CCAT2 expression was tested and its correlation with clinicopathological characteristics of GC was analyzed. We also explored the value of CCAT2 in assessing the treatment efficacy, predicting the fatality, and evaluating the prognosis of patients. Results: We detected higher… More >

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1058

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Xiaolin Wu, Lanping Diao, Guimin Zhao, Chen Huang, Yingzhen Yao, Zhe Gao, Lili Wu^*
Oncologie, Vol.23, No.1, pp. 141-148, 2021, DOI:10.32604/Oncologie.2021.014790
Abstract This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin’s lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin’s lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin’s More >

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Lu Cao^1,*, Dianmei Yang², Bin Bai³
Oncologie, Vol.23, No.1, pp. 149-158, 2021, DOI:10.32604/oncologie.2021.014151
Abstract Objective: This study aimed to explore the miR-1247-mediated promotion of osteosarcoma (OS) cell proliferation by SOX9. Methods: We recruited 97 OS patients admitted to our hospital (the observation group, OG) and 82 healthy people undergoing physical examinations (the control group, CG) over the same period into this study. The expression of miR-1247 and SOX9 in human OS cells in vitro was tested to determine the effect of miR-1247 and SOX9 on OS and to analyze the relationship between miR-1247 and SOX9. Results: We detected lowly expressed miR-1247 and highly expressed SOX9 in the peripheral blood of OS patients… More >

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1127

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Shaoguan Huang¹, Rong Zhang², Lizhen Liu^3,*
Oncologie, Vol.23, No.1, pp. 159-171, 2021, DOI:10.32604/Oncologie.2021.012489
Abstract Breast cancer is one of malignant severe diseases that cause cancer death in women. Although research about the pathogenesis and studies about treatment mechanisms in breast cancer have become clear focuses, we have no clear conclusion yet. Therefore, this research is based on a modular approach to explore key factors and molecular mechanisms that affect breast cancer metastasis. First of all, it is necessary to download breast cancer-related data on the GEO database, and we analyzed the difference between primary tumors and metastatic lesions to obtain differential gene expression profiles. On this basis, a series… More >

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