Open Access
REVIEW
Wan Azani Mustafa1,*, Afiqah Halim1, Khairul Shakir Ab Rahman2
Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660
Abstract Cervical cancer develops as cells transformation in the cervix of a
female that connects the uterus to the vagina. This cancer may impact the
columnal epithelial cells of the cervix and therefore can be expanded to the
lymphatic and circulatory system (metastasize), sometimes the kidneys, liver,
prostate, vagina, and rectum. Many of the cervical cancer patients survived by
taking early prevention by undergoing a Pap Smear Test. However, the result of
the test usually takes a few weeks which is extremely time-consuming especially
at the government hospital. The purpose of this research was to study the
detection and classification method… More >
Open Access
ARTICLE
Neslihan Duzkale1,*, Hikmet Taner Teker2
Oncologie, Vol.22, No.2, pp. 65-74, 2020, DOI:10.32604/ oncologie.2020.013707
Abstract BRCA1/2 genes are responsible for the hereditary breast and ovarian
cancer syndrome. In this study, Turkish women with ovarian cancer were
investigated in terms of demographic, clinicopathologic and family cancer stories
according to their condition of the BRCA1/2 genes mutation carrier. During 2011
to 2017 in Turkey, BRCA1 and BRCA2 genes were analyzed in 38 women, who
were diagnosed with cancer using Next Generation Sequencing technique.
Pathogenic mutations were detected in 9 (23.7%) of patients. The diagnosis age
for Ovarian cancer patients for BRCA1/2 mutation carriers was found higher. It
was seen that mutations mostly occurred in the BRCA2 gene… More >
Open Access
ARTICLE
Dong Zhang1,#, Lingxia Tong2,#, Qingjun Wang1, Yunfeng Cao3, Yu Gao1, Donghua Yang1, Tianhao Bao4,5, Zhitu Zhu1,*
Oncologie, Vol.22, No.2, pp. 75-82, 2020, DOI:10.32604/oncologie.2020.012376
Abstract Predicting the onset and metastasis of early tumor is the primary
means of improving lung cancer prognosis. The purpose of this study was to
identify the ability of plasma metabolomics combined with blood markers to
establish benign lung disease versus lung cancer regression models. Blood
samples were collected from 174 lung cancer patients, 350 benign lung disease
patients and 100 healthy volunteers and the metabolites were analyzed by mass
spectrometry. The target metabolites consisted of 23 amino acids, 26
acylcarnitines and 45 conventional blood markers. A regression analysis model
was established based on 12 metabolites and five blood markers selected… More >
Open Access
ARTICLE
Guiping Chen*, Tiantian Xie, Haibo Chen, Lijuan Chen
Oncologie, Vol.22, No.2, pp. 83-93, 2020, DOI:10.32604/oncologie.2020.012491
Abstract To investigate the expression and clinical significance of miR-152 and
CYFRA21-1 in ovarian cancer (OC) tissues. Seventy-four OC patients diagnosed in
our hospital from March 2016 to April 2019 (research group, RG) and 30 patients
with benign ovarian tumor at the same time (control group, CG) were collected as
research objects in this experiment. qRT-PCR and ELISA were used to detect and
observe the expression levels of miR-152 in patient tissues and CYFRA21-1 in
serum. ROC curves were drawn to analyze the diagnostic value of miR-152 and
CYFRA21-1 in OC. The clinicopathological correlation analysis was observed,
Pearson was used to… More >
Open Access
ARTICLE
Dan Zhang1, Shengyong Fu2,*, Jie Xu3, Xia Sun1
Oncologie, Vol.22, No.2, pp. 95-105, 2020, DOI:10.32604/oncologie.2020.012439
Abstract This study aimed to explore the expression and clinical significance of
LINC01197 in the serum of patients with pancreatic cancer (PC). Methods: A
total of 50 PC patients (patient group) treated in our hospital from March 2012 to
April 2014 were collected, and another 50 healthy people (normal group) were
collected for physical examination. The expression of LINC01197 in the serum of
the two groups was detected by qRT-PCR method, and the expression of CA-199
in serum was detected by Roche automatic biochemistry. The expression and
diagnostic values of CA-199 and LINC01197 in PC were analyzed, and the
relationship between… More >
Open Access
ARTICLE
Haoliang Zhang1,*, Xiaowei Xing2, Yang Liu1, Shuangli Li1, Weiyuan Li3
Oncologie, Vol.22, No.2, pp. 107-116, 2020, DOI:10.32604/oncologie.2020.012494
Abstract Lung cancer is the leading cause of death in cancer patients. Based on
a modular and comprehensive analysis method, it is intended to identify their
common pathogenesis. We downloaded data and analyzed differences in lung
adenocarcinoma samples, lung squamous cell carcinoma samples, and normal
samples. Co-expression analysis, enrichment analysis, and hypergeometric testing
were used to predict transcription factors, ncRNAs, and retrospective target genes.
We get 4596 differentially expressed genes in common differences in high
multiples and clustered into 14 modules dysfunction. The 14 genes (including
DOK2, COL5A1, and TSPAN8) have the highest connectivity in the dysfunction
module and are identified… More >
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