Home / Journals / ONCOLOGIE / Vol.23, No.4, 2021
  • Open Access

    ARTICLE

    Acceptability of Elderly Cancer Patients and Tolerance to COVID-19 Vaccination in the Brittany Region
    L’acceptabilité du Patient Âgé Porteur de Cancer et la Tolérance à la Vaccination Anti-COVID-19 dans la Région Bretagne

    Delphine Déniel1,2,*, Fabienne Le Goc-Le Sager1, Paul Touchard3, Véronique Marty4, Laurence Hasle5, Véronique Jestin Le Tallec6, Monique Jegaden7, Annaïk Pestel8, Virginie Jannou5, Sophie Pentecôte9, Laurence Guen1,2, Christophe Perrin1,10, Sandrine Estivin1,3
    Oncologie, Vol.23, No.4, pp. 453-461, 2021, DOI:10.32604/oncologie.2021.019964
    Abstract Context: Since January 2021, vaccination for COVID-19 has been made possible in France for people aged 75 and over. Patients suffering from a cancer disease are part of a group at risk to develop severe complications to COVID-19. Method: The « Unité de coordination en Onco-Gériatrie région Bretagne » (the Brittany This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Coordinating Unit in Onco-Geriatrics) has wished to set up an inquest about the acceptability and the tolerance to COVID-19 vaccination… More >

  • Open Access

    REVIEW

    Applications of CRISPR-Cas System in Tumor Biology

    Mengdan Ma1,2, Yuchen Liu1,*, Weiren Huang1,*
    Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415
    Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >

  • Open Access

    ARTICLE

    Synthesis, Pharmacological Evaluation, and In-Silico Studies of Thiophene Derivatives

    Raghav Mishra1,2,*, Nitin Kumar3, Neetu Sachan2
    Oncologie, Vol.23, No.4, pp. 493-514, 2021, DOI:10.32604/oncologie.2021.018532
    Abstract The relevance of Retinoic acid receptor-related orphan receptors in cancer progression has sparked interest in developing multifunctional therapeutics. In the search for potentially active novel compounds with anticancer characteristics, the Gewald reaction was employed to develop different thiophene derivatives (8a–8i). Physicochemical and spectroanalytical investigations verified the molecular structures of the synthesized derivatives. Using an in vitro primary anticancer assay, NCI chose all of the synthesized molecules as prototypes and assessed their anticancer efficacy against a panel of various cancer cell lines representing nine distinct neoplasms. The compounds were found to have a wide range of anticancer activity. Following significant anticancer… More >

  • Open Access

    REVIEW

    The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

    Zhengyi Li1,2,3, Lihua Qiu1,2,3,*
    Oncologie, Vol.23, No.4, pp. 515-531, 2021, DOI:10.32604/oncologie.2021.019856
    Abstract Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies… More >

  • Open Access

    ARTICLE

    Predictive Value of p62 Protein in the Recurrence of Oral Squamous Cell Carcinoma

    Xubin Yin1, Bing Yang2, Ming Su2, Shaoshan Sun1, Hao Wang1,*
    Oncologie, Vol.23, No.4, pp. 533-546, 2021, DOI:10.32604/oncologie.2021.018705
    Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using the chi-square test.… More >

  • Open Access

    ARTICLE

    In vivo Effects of Aqueous Extract of Gongronema latifolium Benth on the Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Hepatic Enzymes

    Adekunle Babajide Rowaiye1,2, Moses Okonkwo Njoku3, Angus Nnamdi Oli2, Sousan Akrami4,5, Titilayo Asala1, Ikemefuna Chijioke Uzochukwu6, Alex Akpa1, Morteza Saki4,5,*, Charles Okechukwu Esimone2
    Oncologie, Vol.23, No.4, pp. 547-557, 2021, DOI:10.32604/oncologie.2021.019738
    Abstract Nonsteroidal anti-inflammatory drugs have a number of side effects. However, some medicinal herbs have anti-inflammatory properties with few side effects. This study aimed to determine the effect of the aqueous extract of Gongronema latifolium (AEGL) leaves on the level of tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in rabbits. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the effect of the AEGL on the activities of pro-inflammatory cytokine (TNFα), and regulatory cytokine (TGF-β) in rabbits. Also, a colorimetric method was performed to evaluate the levels of AST and ALT. Overall, the weight… More >

  • Open Access

    ARTICLE

    A Retrospective Analysis of 94 Patients with Hemophagocytic Lymphohistiocytosis of Unknown Etiology from a Single Center

    Xiaodan He, Jingshi Wang, Zhao Wang*
    Oncologie, Vol.23, No.4, pp. 559-567, 2021, DOI:10.32604/oncologie.2021.018647
    Abstract Despite extensive work-ups, some patients have been diagnosed with hemophagocytic lymphohistiocytosis (HLH) of unknown etiology. For HLH of unknown etiology, to investigate the clinical features and the factors that may affect the prognosis, we retrospectively reviewed the medical records of 94 patients hospitalized from January 2014 to December 2019. Survival times were evaluated until April 2020. For the 94 patients, the underlying causes of their diseases remained unclear at the end of the follow-up period, and the 1-, 3-, and 6-month survival rates, and the overall survival (OS) rates were 86.2%, 78.7%, 73.4%, and 70.2%, respectively. The multivariate analysis showed… More >

  • Open Access

    REVIEW

    Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma

    Xingyu Zhu1,2,#, Yongjun Wang3,#, Shuang Chang4,#, Yue Su2, Cuixia He1, Shuang Hu5, Minhui Zhu1, Yuzhou Ding2, Nuannuan Ren2, Qizhi Wang2, Jing Xie1,*, Huan Zhou1,2,*
    Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869
    Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function… More >

  • Open Access

    ARTICLE

    Circular RNA hsa_circ_0016863 Regulates the Proliferation, Migration, Invasion and Apoptosis of Hepatocellular Carcinoma

    Ping Zhao1,#, Yao Xu1,#, Anqi Wu2, Yuhao Hu2, Aiting Cai2, Xinyue Wang3, Feng Wang2,*, Xiang Chen1,*
    Oncologie, Vol.23, No.4, pp. 589-601, 2021, DOI:10.32604/oncologie.2021.018713
    Abstract Background: Although there has been a part of research that the expression of circular RNAs (circRNAs) is bound up with the occurrence, development and prognosis of multiple tumors, what roles circRNAs have in hepatocellular carcinoma (HCC) remain to be explored. Methods: Hsa_circ_0016863 showed a trend of high expression in HCC tissues by Microarray GSE97332. The expression of hsa_circ_0016863 in HCC and adjacent non-cancerous tissues was detected by qRT-PCR. The role of hsa_circ_0016863 in HCC was investigated by colony formation assay, cell proliferation assay, Transwell assay and flow cytometry. Results: Hsa_circ_0016863 exhibited a trend of high expression in HCC. Cell experiments… More >

  • Open Access

    CASE REPORT

    A Rare Case of Atraumatic Splenic Rupture Due to Metastatic Hepatocellular Carcinoma

    Dang Quang Hung1,#, Nguyen-Thi Nhan1, Trinh-Thi Phuong Nga1, Nguyen Thanh Hai1, Nguyen Quang Duc1, Nguyen Viet Thu1, Nguyen Truong Duc1, Dinh-Van Thuyet1, Nguyen Minh Duc2,#,*,ORCID
    Oncologie, Vol.23, No.4, pp. 603-608, 2021, DOI: 10.32604/oncologie.2021.019519
    Abstract Metastatic spread of hepatocellular carcinoma (HCC) to the spleen is uncommon, only occurring in approximately 1% of cases. Atraumatic splenic rupture due to HCC metastasis is extremely rare and affects patient prognosis, clinical management, and mortality. We report a case of a 65-year-old man with a history of chronic hepatitis B infection who presented with left-sided abdominal pain and fatigue. Clinical examination showed acute anemia with elevated levels of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). On ultrasound and computed tomography imaging, hemoperitoneum caused by a ruptured splenic tumor was revealed. In addition to multiple hepatic… More >

  • Open Access

    RETRACTION

    Retraction Notice to: LncRNA TUG1 Targets miR-222-3p to Take Part in Proliferation and Invasion of Breast Cancer Cells

    Yuqin Xie, Shuang Deng, Qian Deng, Jiudong Xu
    Oncologie, Vol.23, No.4, pp. 609-609, 2021, DOI:10.32604/oncologie.2021.020379
    Abstract This article has no abstract. More >

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