The polarized autologous macrophages can be used as a tumor vaccine for preventing postoperative tumor recurrence. This scheme illustrates how autologous M1 macrophages are prepared from the mice and then embedded into a sodium alginate gel to make an implantable tumor vaccine (M1@Gel). M1@Gel can repolarize tumor-associated macrophages and prevent the tumor recurrence in mice after the surgical tumor removal. Therefore, the implantation of autologous M1 macrophages might be a promising strategy for developing tumor vaccine.
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STUDY PROTOCOL IN FRENCH
Virginie Prevost1,2,#,*, Pauline Drillon3,#, Antoine Desvergée4, Corinne Delcambre2, Claire Delorme2, Anne Besnier5, Kévin Lecaplain6, Charline Frandemiche7, Anaïs Briant7, Rémy Morello4, Xavier Blaizot7
Oncologie, Vol.24, No.3, pp. 357-369, 2022, DOI:10.32604/oncologie.2022.025107
Abstract Breast cancer is the most common cancer in women and approximately 80% of patients will receive hormone
therapy. If survival rate after breast cancer patients is the most important, their treatment, induces strong side
effects on quality of life, including joint pain which is encountered by one woman in two. These joint pains
are likely to reduce compliance with the treatment and consequently impact survival. In this context, this work
aims to evaluate the potential benefit of adapted physical activity to relieve pain and its impact on daily functions.
The APAISE protocol, described in this article, is a prospective observational… More >
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REVIEW
Natalia Roque1,#, Diana Matias2,#, Joana Balça-Silva3, Valéria Pereira Ferrer4, Luciana Santos Pessoa1, Tania Cristina Leite de Sampaio e Spohr1,5,*
Oncologie, Vol.24, No.3, pp. 371-411, 2022, DOI:10.32604/oncologie.2022.024035
Abstract Cancer is one of the deadliest diseases with a cure far from being found. Despite the extraordinary advances in the therapy approaches, only a few patients respond to treatments. The tumor microenvironment (TME) plays a crucial role in cancer progression by contributing to the chemoresistance. Thus, emerging efforts are being made in nanotechnology research focusing on nanoparticles’ potential role and their application in immune system modulation. Moreover, the omics have contributed to bioengineering and nanotechnology development by elucidating the mechanisms of cancer and specific biomarkers that could be used as new therapeutic targets. Furthermore, the non-coding microRNA as a target… More >
Open Access
REVIEW
Abolfazl Jafari-Sales1, Afsoon Shariat1,*, Hossein Bannazadeh Baghi2, Behzad Baradaran3, Behboud Jafari4
Oncologie, Vol.24, No.3, pp. 413-426, 2022, DOI:10.32604/oncologie.2022.024161
Abstract Background and Aim: Gastric cancer (GC) is one of the most common infection-related malignancies worldwide. Human Papillomavirus (HPV) and Epstein-Barr virus (EBV) are among the most important viruses affecting many people worldwide. The potential role of these viruses in gastric tissue may explain the possibility of GC,
as seen in Helicobacter pylori (H. pylori). This study aimed to systematically investigate the presence of HPV and
EBV in GC. Methods: According to the Preferred Reporting Items for Systematic reviews and Meta-Analyses
(PRISMA) guidelines, this study is a systematic review based on reported cases. The keywords HPV, EBV and
GC, were searched… More >
Open Access
REVIEW
Xin Shu, Qiang Wang*, Qingming Wu*
Oncologie, Vol.24, No.3, pp. 427-439, 2022, DOI:10.32604/oncologie.2022.023248
Abstract Liver cancer is ranked as the second leading cause of cancer-related death across the world, and hepatocellular
carcinoma (HCC) comprises nearly 90% of all primary liver cancer cases. However, until now, the pathological
mechanisms underlying HCC oncogenesis and development remains largely unclear. Eph receptors and their
ephrin ligands (Eph/Ephrin system) are involved in various physiological process, such as embryogenesis, neuronal migration, immune response and vascular development. Recently, emerging evidence has showed that the
Eph/Ephrin system also plays an essential role in initiation and development of multiple types of cancer, including
liver cancer. The Eph/Ephrin system has been reported to contribute… More >
Open Access
ARTICLE
Dongqing Wang1,*, Heying Chen1, Yi Hu2,*
Oncologie, Vol.24, No.3, pp. 441-449, 2022, DOI:10.32604/oncologie.2022.024898
（This article belongs to this Special Issue: Cancer Immunotherapy)
Abstract Immunotherapy is currently recognized as one of the most promising anticancer strategies. In the tumor microenvironment, tumor-associated macrophages are mainly M2-type macrophages with tumor-promoting effects.
Therefore, the reprogramming of tumor-associated macrophages from M2 to M1 type is a potential strategy
for cancer therapy. We have previously shown the anticancer effects of implantable allogeneic M1 macrophages
in mice. Here, we further engineered autologous mouse bone marrow cells into M1 macrophages and then
embedded them into a sodium alginate gel to prepare an implantable immunotherapeutic agent (M1@Gel).
We demonstrate that M1@Gel repolarizes M2 macrophages to M1 type and activates the immune responses… More >
Open Access
ARTICLE
Xujie Zhou1,2,3,#, Yuting Sang1,3,#, Jiajian Chen1,3, Miao Mo3,4, Jianjing Hou1,3, Benlong Yang1,3,*, Jiong Wu1,2,3,*
Oncologie, Vol.24, No.3, pp. 451-469, 2022, DOI:10.32604/oncologie.2022.025226
Abstract Background: To compare the time-varying recurrence patterns of different molecular subtypes of breast cancer in
the contemporary era with those in the past era. Patients and Methods: This retrospective study included
14627 consecutive invasive breast cancer patients who underwent surgery from 2008 to 2016 at Fudan University
Shanghai Cancer Center. We defined the period from 2013 to 2016 as the contemporary era and that from 2008 to
2012 as the past era. Five subtypes were defined according to the immunohistochemistry results. Emphasis was
made on the changing patterns of recurrence for patients with different molecular subtypes changed between the
two… More >
Open Access
ARTICLE
Dongliang Zhu1,*, Jun Yang2, Jiaxin Xu3
Oncologie, Vol.24, No.3, pp. 471-482, 2022, DOI:10.32604/oncologie.2022.024062
Abstract G-protein coupled estrogen receptor (GPER) is a transmembrane receptor that mediates non-genomic effects of
estrogen. This study aimed to investigate the role of GPER in the stemness formation and malignancies in triple
negative breast cancer (TNBC) cells. Spheroids of MDA-MB-468 cells were induced by mammosphere culture,
and the proportion of the CD44+
/CD24−/low stem cell subpopulation was detected. Malignant characteristics,
expression of GPER and stemness-related markers, and tumorigenesis in a xenograft assay were compared
between the mammospheres and adherent cultured cells. The impacts of 17β-estradiol (E2) and the GPER-specific
antagonist G15 were studied in in vitro assays. The proportion of… More >
Open Access
ARTICLE
Rong Zeng1,#, Lin Liu1,2,#, Jingshan Zhao1,2,3,#, Wenmei Zhang3, Guohong Zhang1, Yunfeng Li1,2,*
Oncologie, Vol.24, No.3, pp. 483-498, 2022, DOI:10.32604/oncologie.2022.025148
Abstract Background: Breast cancer (BC) is the most frequent type of gynecology tumors with high morbidity and mortality. Ampelopsin, the main active compound of Ampelopsis grossedentata, exerts an anti-tumor effect on a variety of cancers. However, the anti-cancer role of ampelopsin in BC remains unclear. The aim of this study is to
explore the mechanism of ampelopsin against breast cancer. Materials and Methods: The target genes of ampelopsin in the treatment of breast cancer were determined and analyzed by network pharmacology and molecular
docking. Cytoscape software was used to identify the core target genes and construct a protein–protein interaction
(PPI) network.… More >
Open Access
ARTICLE
Yao Wu1,2,#, Bin Qu1,#, Haoming Shen1, Hongyu Deng1, Faqin Tang1,*
Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951
Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value
is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma
(NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC),
breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected
using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment TSGF levels of… More >
Open Access
ARTICLE
Xinyue Wang1,#, Jing Xu1,#, Qihong Gu1, Dingxuan Tang1, Huoyan Ji2, Shaoqing Ju2, Feng Wang2,*, Lin Chen3, Ruoyu Yuan2,*
Oncologie, Vol.24, No.3, pp. 513-526, 2022, DOI:10.32604/oncologie.2022.024373
Abstract Background: MicroRNAs (miRNAs) have been identified as promising novel biomarkers for cancer diagnosis and
prognosis, especially for hepatocellular carcinoma (HCC). Nowadays, the expression level of miR-21 in serum
samples is a diagnostic indicator for HCC diagnosis. Thus, the quantitative determination of miRNA concentration is of significance in clinical practice. It is particularly important to establish an analytical detection method
for miR-21 in patient serum. Methods: The signal readout for miR-21 was based on the mass response of a reporter peptide using an isotope dilution mass spectrometry (MS) method in this work. To be more specific, miR-21
was biotinylated before being… More >
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