Home / Journals / ONCOLOGIE / Vol.24, No.1, 2022
  • Open Access

    EDITORIAL

    Oncologie Issue 1, 2022

    Daniel Serin
    Oncologie, Vol.24, No.1, pp. 1-2, 2022, DOI:10.32604/oncologie.2022.020553
    Abstract This article has no abstract. More >

  • Open Access

    REVIEW IN FRENCH

    Hairy Cell Leukemia and HCL-Like Disorders: Diagnosis and Treatment
    Leucémie à Tricholeucocytes et Autres Proliférations à Cellules Chevelues: Diagnostic et Traitement

    Elsa Maitre, Xavier Troussard*
    Oncologie, Vol.24, No.1, pp. 3-24, 2022, DOI:10.32604/oncologie.2022.021490
    Abstract Hairy cell leukemia (LT) accounts for 2% of all leukemias. The diagnosis is based on the presence in the blood and/ or the marrow of hairy cells expressing CD103, CD123, CD11c and CD25. The BRAFV600E mutation, a molecular marker of the disease, is present in more than 80% of cases. LT should be distinguished from other chronic B-cell lymphoproliferative disorders, including the variant form of hairy cell leukemia (HCL-V) and diffuse splenic red pulp lymphoma (DSRPL). Progress has recently been made in the management of patients. The purine analogues (PNAs) in monotherapy, deoxycoformycin (DCF) or 2-chloro-deoxyadenosine (CDA), remain the first-line… More >

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    VIEW POINT IN FRENCH

    Manual Lymphatic Drainage for Upper Limb Lymphedema: A Clinician’s Perspective for its Adaptation
    Adapter le Drainage Lymphatique Manuel pour le Lymphœdème du Membre Supérieur: Point de vue de Cliniciens

    Jean-Claude Ferrandez1,*, Pierre-Henri Ganchou2, Serge Theys3, Maria Torres-Lacomba4, Daniel Serin1
    Oncologie, Vol.24, No.1, pp. 25-33, 2022, DOI:10.32604/oncologie.2022.018110
    Abstract Upper limb lympedema is a frequent consequence of breast cancer treatment. The International Society of Lymphology recommends physical therapy for lymphedema management. This treatment includes a combination of manual lymphatic drainage and high-compression bandaging. Actually, the effectiveness of manual lymphatic drainage remains an area of controversy, especially because of the many different techniques called “manual lymphatic drainage” since 1930. The purpose of this review was to emphasise the efficacy of these different techniques according to physiological data and evidence-based practice. To improve the manual lymphatic drainage efficiency, the pressure, sometimes important, should be tailored to each edema and the techniques… More >

  • Open Access

    REVIEW

    Technological Innovations in Thyroid Cancer Surgery

    Federico Cappellacci*, Gian Luigi Canu, Stefano Piras, Giacomo Anedda, Pietro Giorgio Calò, Fabio Medas
    Oncologie, Vol.24, No.1, pp. 35-50, 2022, DOI:10.32604/oncologie.2022.020864
    Abstract Thyroid cancer is the fifth most common cancer in the USA, with differentiated subtype accounting for more than 95% of neoplasm. Surgery remains the mainstay of treatment, either with lobectomy or total thyroidectomy. In the last decades, many technological innovations have been introduced in this field. The aim of this review is to illustrate the most recent advances regarding the classical surgical approach, particularly regarding hemostatic devices, parathyroid identification with fluorescence systems, intraoperative identification of lymph node metastases, and intraoperative neuromonitoring. More >

  • Open Access

    REVIEW

    The Integrated Histopathologic and Molecular Approach to Adult-type Diffuse Astrocytomas: Status of the Art, Based on the 2021 WHO Classification of Central Nervous System Tumors

    Hiba Alzoubi1, Alameen Alsabbah2, Rosario Caltabiano3, Giuseppe Broggi3,*
    Oncologie, Vol.24, No.1, pp. 51-63, 2022, DOI:10.32604/oncologie.2022.020890
    Abstract The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) improved our understanding of the brain neoplasm biology. In more details, differences between diffuse gliomas that primarily occur in adults and those that primarily occur in children have been identified by the terms “adult-type” and “pediatric-type” diffuse gliomas. More importantly, both diagnostic and grading criteria for adult-type diffuse astrocytomas have been modified, by adopting novel molecular markers: diffuse astrocytomas, IDH-mutant have been grouped into a single entity and graded as CNS WHO grades 2, 3, or 4, with the assignment of Grade 4 in the… More >

  • Open Access

    REVIEW

    Gene Editing in Non-Small Cell Lung Cancer: Current Application and Future Perspective

    Hangxing Wang1,#, Jingyun Fang1,#, Yujiao Wang2,#, Shuo Li2, Zirui Wang2, Wei He2, Nan Wang1, Shuang Luo1, Huimei Zou3,*, Fan Zhang4,5,*
    Oncologie, Vol.24, No.1, pp. 65-83, 2022, DOI:10.32604/oncologie.2022.021863
    Abstract Lung cancer is the most common malignant tumor with the highest morbidity and mortality in the world, and non-small cell lung cancer (NSCLC) accounts for the vast majority of cases. At present, its main treatment methods are still traditional surgery, radiotherapy and chemotherapy, with disadvantages such as a high recurrence rate and limited effectiveness. Therefore, a new, better treatment method is urgently needed. Gene editing technology, as a new genetic engineering approach, has shown great potential in gene research, gene therapy and genetic improvement. It has also emerged as a promising treatment for lung cancer. This paper reviews the current… More >

  • Open Access

    REVIEW

    Ubiquitin Specific Protease 2: Structure, Isoforms, Cellular Function, Related Diseases and Its Inhibitors

    Hao Luo1,#,*, Yanjie Ji2,#, Xinrong Gao1, Xinying Liu1, Yunzhao Wu3, Yingli Wu3,*
    Oncologie, Vol.24, No.1, pp. 85-99, 2022, DOI:10.32604/oncologie.2022.021705
    Abstract The ubiquitin-proteasome system (UPS) is an important pathway for cellular protein degradation. The components of this pathway, including the proteasome, ubiquitinase, and deubiquitinase, are highly specialized and strictly regulated. The ubiquitin-specific protease 2 (USP2) belongs to the ubiquitin-specific proteases, a subgroup of deubiquitinating enzymes. USP2 plays essential roles in regulating cell survival, cell cycle, circadian rhythm, cell metabolism, inflammatory response, antiviral response, and metastasis by interacting with certain proteins such as Cyclin D1, PER1, CRY1, HDM2/p53, FASN, LDLR, TRAF6, TBK1, and TGFBR1-TGFBR2 complex. Elevation of USP2 has been observed in a variety of cancers, including glioma, testicular cancer, breast cancer,… More >

  • Open Access

    ARTICLE

    Exploration of Combinational Therapeutic Strategies for HCC Based on TCGA HCC Database

    Dong Yan1,#, Chunxiao Li2,#, Yantong Zhou2, Xue Yan1, Weihua Zhi1, Haili Qian2,*, Yue Han1,*
    Oncologie, Vol.24, No.1, pp. 101-111, 2022, DOI:10.32604/oncologie.2022.020357
    Abstract Hepatocellular carcinoma (HCC) is one of the most deadly types of cancer. Sorafenib is currently the only available first-line molecular targeted drug approved by the FDA for HCC. However, primary and secondary resistance is often encountered with treatment with sorafenib. Genomic alterations found in HCC represent potential targets to develop new drugs or new combinational strategies against this type of cancer. Here we analyzed genomic alterations from the TCGA database of HCC samples and the corresponding targeted drugs available to the clinic to identify candidate drugs that might hold promise when used in combination with sorafenib. Our results revealed that… More >

  • Open Access

    ARTICLE

    Racial Bias Can Confuse AI for Genomic Studies

    Beifen Dai1,#, Zhihao Xu2,#, Hongjue Li3, Bo Wang3, Jinsong Cai1, Xiaomo Liu4,*
    Oncologie, Vol.24, No.1, pp. 113-130, 2022, DOI:10.32604/oncologie.2022.020259
    Abstract Large-scale genomic studies are important ways to comprehensively decode the human genomics, and provide valuable insights to human disease causalities and phenotype developments. Genomic studies are in need of high throughput bioinformatics analyses to harness and integrate such big data. It is in this overarching context that artificial intelligence (AI) offers enormous potentials to advance genomic studies. However, racial bias is always an important issue in the data. It is usually due to the accumulation process of the dataset that inevitability involved diverse subjects with different races. How can race bias affect the outcomes of AI methods? In this work,… More >

  • Open Access

    ARTICLE

    A Real-World Study on Oral Vinorelbine for the Treatment of Metastatic Breast Cancer

    Jiayi Huang1, Xue Bai1, Xiaofeng Xie1, Liping Chen1, Xiaofeng Lan1, Qiuyi Zhang1, Lin Song1, Pengjiao Hong2,3, Caiwen Du1,*
    Oncologie, Vol.24, No.1, pp. 131-145, 2022, DOI:10.32604/oncologie.2022.019881
    Abstract Background: Vinorelbine can be used to treat metastatic breast cancer as a single agent or in combination with other chemotherapy agents, although there is little real-world data for its use, particularly the oral form, in China. The current study aimed to explore the efficacy and safety of oral vinorelbine in patients with metastatic breast cancer in real-world clinical practice. Methods: A total of 194 patients with metastatic breast cancer received oral vinorelbine as a treatment between February 2017 and January 2021 at the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences… More >

  • Open Access

    ARTICLE

    Tumor-Associated Macrophages Facilitate the Proliferation and Migration of Cervical Cancer Cells

    Yi Zheng1, Youyou Wang2, Chen Zou1, Bicheng Hu2, Min Zhao2, Xinxing Wu2,*
    Oncologie, Vol.24, No.1, pp. 147-161, 2022, DOI:10.32604/oncologie.2022.019236
    Abstract Tumor-associated macrophages (TAMs) are important components in tumor microenvironment. This study intended to explore the influence of TAMs on cervical cancer cells proliferation and migration. The expression levels of TAMs markers, CD68 and CD163, in tissues were examined by immunohistochemistry and increased with the progression of cervical lesions (p < 0.05). TAMs with M2-like phenotype (PMA(Polymethacrylate) induced THP-1 cells) were noticed to promote the proliferation of cervical cancer cells and improve the migration ability of tumor cells. These enhancements were attributed to secreting soluble components and the physical contact between macrophages and tumor cells. The tumor formation and tumor growth… More >

  • Open Access

    CASE REPORT

    A Primary Sacral Melanoma of Unknown Origin: A Case Report

    Ismail Bozkurt1,*, Baris Yasar1, Mehmet Baran Uslu2, Nazan Bozdogan3
    Oncologie, Vol.24, No.1, pp. 163-171, 2022, DOI:10.32604/oncologie.2022.019263
    Abstract Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4–5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant… More >

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