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Tumor-Associated Macrophages Facilitate the Proliferation and Migration of Cervical Cancer Cells

Yi Zheng1, Youyou Wang2, Chen Zou1, Bicheng Hu2, Min Zhao2, Xinxing Wu2,*

1 Central Laboratory, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, 518016, China
2 Institute of Virology, School of Basic Medical Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, 430071, China

* Corresponding Author: Xinxing Wu. Email:

Oncologie 2022, 24(1), 147-161.


Tumor-associated macrophages (TAMs) are important components in tumor microenvironment. This study intended to explore the influence of TAMs on cervical cancer cells proliferation and migration. The expression levels of TAMs markers, CD68 and CD163, in tissues were examined by immunohistochemistry and increased with the progression of cervical lesions (p < 0.05). TAMs with M2-like phenotype (PMA(Polymethacrylate) induced THP-1 cells) were noticed to promote the proliferation of cervical cancer cells and improve the migration ability of tumor cells. These enhancements were attributed to secreting soluble components and the physical contact between macrophages and tumor cells. The tumor formation and tumor growth were significantly faster in the mixed group of induced THP-1 cells and SiHa than in the SiHa cells alone group (p < 0.05). The results indicated that the interaction of macrophages and cervical cancer cells, including the secretion of soluble components and physical contact, were responsible for shaping immunosuppression microenvironments and in promoting tumor cell proliferation and migration.


Cite This Article

Zheng, Y., Wang, Y., Zou, C., Hu, B., Zhao, M. et al. (2022). Tumor-Associated Macrophages Facilitate the Proliferation and Migration of Cervical Cancer Cells. Oncologie, 24(1), 147–161.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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