Jin Liu^1,2, Xiu Zhang¹, Xiao Hu², Gaofeng Yuan², Kai Chen^1,*

BIOCELL, Vol.49, No.4, pp. 665-680, 2025, DOI:10.32604/biocell.2025.063296 - 30 April 2025

Abstract Objective: This study examines the significance and functions of CLDN9 in gastric cancer (GC), intending to identify novel targets for diagnosis and treatment. Methods: CLDN9 expression in GC tissues and cell lines was investigated in TCGA data, with analysis with Western blotting, qRT-PCR, and immunohistochemical analyses. Correlations between clinicopathological characteristics, progression-free survival (PFS), and overall survival (OS) were assessed with Cox regression. The effect of CLDN9 knockdown/overexpression on tumorigenic functions (proliferation, migration, and invasion) was assessed using CCK-8, colony formation, and Transwell assays. Tumor-bearing assays were performed to verify the impact of CLDN9 knockdown on… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.5, pp. 1251-1252, 2025, DOI:10.32604/or.2025.065346 - 18 April 2025

Abstract This article has no abstract. More >

HYEONG SIM CHOI¹, JEONG-KUI KU¹, SEONG-GYU KO², PIL-YOUNG YUN^1,3,*

Oncology Research, Vol.33, No.5, pp. 1217-1227, 2025, DOI:10.32604/or.2025.059791 - 18 April 2025

Abstract Background: Oral cancer remains a significant global health challenge, as it has high morbidity and mortality rates. Current treatments show limited efficacy and have severe side effects, prompting searches for new therapeutic agents. SH003, a traditional herbal formulation comprising Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, has demonstrated potential anticancer properties in previous studies. However, its specific efficacy against oral cancer and the role of its key components, particularly Cucurbitacin D, remain underexplored. Methods: The cytotoxic effects of SH003 and its major components—i.e., Cucurbitacin D, Decursin, Formononetin, and Nodakenin—were evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT), Trypan Blue exclusion, and… More >

Baoli Zang¹, Liyang Shao¹, Yang Li¹, Hao Ran², Liangwen Wei^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.3, pp. 555-571, 2025, DOI:10.32604/fdmp.2024.054275 - 01 April 2025

Abstract This study focuses on addressing ventilation and dust removal challenges during the construction of small-section tunnels using drilling and blasting techniques. Specifically, the research examines the shale gas gathering and transmission trunk line project in the Weiyuan and Luzhou blocks. To gain deeper insights into dust migration patterns, numerical simulations were conducted. The study further analyzed dust migration behavior in small-section tunnels and large steep-sloped shafts, taking into account various factors such as ventilation distance, tunnel slope, and section size. The results indicate that optimal ventilation occurs at distances of 15 and 13 m. Additionally, More >

Chang Wang^1,2,#, Zhi Zhang^1,#, Wei Sun¹, Quan Quan³, Wenshuang Hou³, Chenghao Jin^1,3,4,*

BIOCELL, Vol.49, No.3, pp. 465-482, 2025, DOI:10.32604/biocell.2025.062155 - 31 March 2025

Abstract Objectives: Epibrassinolide (EBR) is a steroid hormone with anti-tumor properties. Nevertheless, its potential to inhibit gastric cancer (GC) cells remains unknown. The aim of this research was to examine the effects of EBR on GC cells and to investigate the specific mechanism of EBR. Methods: A cell counting kit-8 (CCK-8) assay was utilized to determine cell survival rates. The investigation of apoptosis, cell cycle progression, and reactive oxygen species (ROS) levels was performed using flow cytometry. To detect cell migration, a wound-healing assay was performed on AGS cells. Furthermore, western blotting assay was utilized to determine… More >

Hongjuan Guo¹, Dan Liu^1,2, Ruyu Yan^1,2, Tianjing Zhang³, Kecheng Zhou^1,2,*, Minxia Liu^1,*

BIOCELL, Vol.49, No.3, pp. 483-502, 2025, DOI:10.32604/biocell.2025.062143 - 31 March 2025

Abstract Objectives: Non-small cell lung cancer (NSCLC) represents a formidable malignancy characterized by its marked metastatic potential and intrinsic resistance to therapeutic interventions. The identification of potential biomarkers delineating the progression and metastatic cascade of NSCLC assumes paramount importance in fostering advancements toward enhanced patient outcomes and prognostic stratification. Methods: The expression level of the actin-related protein 2/3 complex; subunit 1A (ARPC1A) in NSCLC was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases; along with the LinkedOmics database for co-expression genes. Further verification of ARPC1A expression in normal lung cells… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.4, pp. 991-991, 2025, DOI:10.32604/or.2024.056914 - 19 March 2025

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

Abstract This article has no abstract. More >

Hamayun Khan^1,*, Muhammad Atif Imtiaz², Hira Siddique³, Muhammad Tausif Afzal Rana⁴, Arshad Ali⁵, Muhammad Zeeshan Baig⁶, Saif ur Rehman⁷, Yazed Alsaawy⁵

Computer Systems Science and Engineering, Vol.49, pp. 317-331, 2025, DOI:10.32604/csse.2025.061118 - 19 March 2025

Abstract The migration of tasks aided by machine learning (ML) predictions IN (DPM) is a system-level design technique that is used to reduce energy by enhancing the overall performance of the processor. In this paper, we address the issue of system-level higher task dissipation during the execution of parallel workloads with common deadlines by introducing a machine learning-based framework that includes task migration using energy-efficient earliest deadline first scheduling (EA-EDF). ML-based EA-EDF enhances the overall throughput and optimizes the energy to avoid delay and performance degradation in a multiprocessor system. The proposed system model allocates processors… More >

Lingling Zhang^1,2, Hualing Wang³, Yawen Liu², Ling Li^2,*, Jianping Xiong^1,4,*

BIOCELL, Vol.49, No.2, pp. 253-267, 2025, DOI:10.32604/biocell.2025.061585 - 28 February 2025

Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >