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  • Open Access


    Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer Progression by Activation of NOTCH1 Pathway

    Ying Ye, Yanan Song, Juhua Zhuang, Saifei He, Jing Ni, Wei Xia

    Oncology Research, Vol.26, No.9, pp. 1383-1390, 2018, DOI:10.3727/096504018X15188340975709

    Abstract Long noncoding RNA CCAL has been reported to promote tumor progression in various human cancers, including hepatocellular carcinoma, osteosarcoma, and colorectal cancer. However, the role of CCAL in papillary thyroid cancer remains largely unknown. In the present study, we found that the expression of CCAL was upregulated in papillary thyroid tumor tissues compared to adjacent normal tissues. Moreover, the expression of CCAL was positively related with papillary thyroid cancer severity and TNM stage and predicated poor prognosis. Besides, we found that knockdown of CCAL significantly inhibited papillary thyroid cancer cell proliferation, migration, and invasion in More >

  • Open Access


    [ARTICLE WITHDRAWN] MicroRNA-18a Targets IRF2 and CBX7 to Promote Cell Proliferation in Hepatocellular Carcinoma

    Yongyu Zhang1, Lewei Yang2, Jian Liu3, Yuqin Sun4

    Oncology Research, Vol.26, No.9, pp. 1327-1334, 2018, DOI:10.3727/096504018X15165493852990


  • Open Access


    Long Noncoding RNA GAS5 Promotes Proliferation, Migration, and Invasion by Regulation of miR-301a in Esophageal Cancer

    Wei Li, Weidong Zhao, Zhaohui Lu, Wen Zhang, Xuan Yang

    Oncology Research, Vol.26, No.8, pp. 1285-1294, 2018, DOI:10.3727/096504018X15166193231711

    Abstract Long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) has been revealed to be associated with the progression of various cancers. However, the biological roles of GAS5 in esophageal cancer (EC) remain unclear. We aimed to thoroughly explore the functions of GAS5 in EC. The results showed that GAS5 expression was increased in EC cells (ECA109, TE-1, TE-3, and EC9706) compared to SHEE cells. Knockdown of GAS5 decreased cell viability, migration, and invasion and induced apoptosis in EC9706 cells. Moreover, miR-301a appeared to be directly sponged by GAS5, and miR-301a suppression obviously alleviated the protumor More >

  • Open Access


    Long Noncoding RNA FGFR3-AS1 Promotes Hepatocellular Carcinoma Carcinogenesis via Modulating the PI3K/AKT Pathway

    Juhua Zhuang*1, Saifei He*1, Guoyu Wang*, Guangdong Wang*†, Jing Ni*, Suiliang Zhang, Ying Ye*, Wei Xia*

    Oncology Research, Vol.26, No.8, pp. 1257-1265, 2018, DOI:10.3727/096504018X15172756878992

    Abstract Hepatocellular carcinoma (HCC) as one of the most refractory cancers leads to high mortality worldwide. Long noncoding RNAs have been widely acknowledged as important biomarkers and therapeutic targets in HCC. In this study, we investigated the effects of long noncoding RNA FGFR3-AS1 on tumor growth and metastasis in HCC. First, we found that the expression of FGFR3-AS1 was upregulated about threefold in HCC samples and cell lines. We knocked down FGFR3-AS1 in Huh7 and Hep3B cells and found that FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis. Moreover, FGFR3-AS1 knockdown led to more HCC More >

  • Open Access


    Triptolide Inhibits Proliferation and Migration of Human Neuroblastoma SH-SY5Y Cells by Upregulating MicroRNA-181a

    Jian Jiang*, Xuewen Song, Jing Yang*, Ke Lei*, Yongan Ni*, Fei Zhou, Lirong Sun*

    Oncology Research, Vol.26, No.8, pp. 1235-1243, 2018, DOI:10.3727/096504018X15179661552702

    Abstract Neuroblastoma is the primary cause of cancer-related death for children 1 to 5 years of age. New therapeutic strategies and medicines are urgently needed. This study aimed to investigate the effects of triptolide (TPL), the major active component purified from Tripterygium wilfordii Hook F, on neuroblastoma SH-SY5Y cell proliferation, migration, and apoptosis, as well as underlying potential mechanisms. We found that TPL inhibited SH-SY5Y cell viability, proliferation, and migration, but induced cell apoptosis. The expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 after TPL treatment in SH-SY5Y cells was decreased. The expression of microRNA-181a (miR-181a) was upregulated More >

  • Open Access


    Transglutaminase 2 Promotes Migration and Invasion of Lung Cancer Cells

    Hung-Tsung Lee*, Cheng-Hsieh Huang, Wuan-Chun Chen, Chi-Shan Tsai, Yu-Lin Chao, Szu-Han Liu, Jun-Hong Chen, Yi-Ying Wu, Yi-Ju Lee†§

    Oncology Research, Vol.26, No.8, pp. 1175-1182, 2018, DOI:10.3727/096504018X15149761920868

    Abstract Lung cancer is the leading cause of cancer deaths worldwide. Given that the major threat of cancer is metastasis, delineation of the molecular mechanism underlying it would help devise therapeutic strategies. Transglutaminase 2 (TG2), belonging to the transglutaminase superfamily, is a versatile protein with enzymatic and nonenzymatic functions. It mainly localizes inside the cell, but also appears extracellularly. Recent findings have demonstrated the involvement of TG2 in cancer development. Here we examine the role of TG2 in metastasis of lung cancer using a lung cancer cell line CL1-0, which exhibits low invasiveness, and its invasive… More >

  • Open Access


    Silencing of lncRNA CCDC26 Restrains the Growth and Migration of Glioma Cells In Vitro and In Vivo via Targeting miR-203

    Shilei Wang*, Yuzuo Hui*, Xiaoming Li, Qingbin Jia*

    Oncology Research, Vol.26, No.8, pp. 1143-1154, 2018, DOI:10.3727/096504017X14965095236521

    Abstract Gliomas are the most common primary brain tumors with high mortality. The treatment for gliomas is largely limited due to its uncomprehending pathological mechanism. Here we aimed to investigate the effect of long noncoding RNA (lncRNA) coiled-coil domain-containing 26 (CCDC26) in glioma progression. In our study, the expression of CCDC26 was found upregulated in glioma tissues and cell lines compared with normal tissues and cell lines. Further exploration detected decreased cell proliferation and increased cell apoptosis in U-251 and M059J cells transfected with CCDC26-siRNA. In addition, the silencing of CCDC26 strongly reduced the wound closing… More >

  • Open Access


    Matrine Inhibits Neuroblastoma Cell Proliferation and Migration by Enhancing Tribbles 3 Expression

    Xiaowei Shen*1, Jianping Huang†1, Gang Liu, Hao Zhang, Xiwei Zhang, Xiancheng Kong, Lei Du

    Oncology Research, Vol.26, No.7, pp. 1133-1142, 2018, DOI:10.3727/096504018X15168461629558

    Abstract Neuroblastoma is a major contributor of cancer-specific mortality. Although remarkable enhancement has been achieved in the treatment of neuroblastoma in patients with early stage disease, limited progress has been made in the treatment of patients with high-risk neuroblastoma. Thus, innovative approaches are required to achieve further improvements in neuroblastoma patient survival outcomes. The major alkaloid obtained from Sophora flavescens Ait, matrine, has been shown to counteract malignancy in various kinds of cancers. In the current study, we evaluated the effects of matrine on the migration and proliferation of neuroblastoma cells. Cell cycle analysis coupled with Transwell More >

  • Open Access


    Let-7c Inhibits the Proliferation, Invasion, and Migration of Glioma Cells via Targeting E2F5

    Mengyi Huang, Xin Gong

    Oncology Research, Vol.26, No.7, pp. 1103-1111, 2018, DOI:10.3727/096504018X15164123839400

    Abstract As a member of the miRNA family, let-7c has been identified as a tumor suppressor in many cancers. However, the molecular biological function of let-7c in glioma has not been elucidated. The aim of this study was to explore let-7c expression levels and evaluate its function in glioma cells. We first measured the expression of let-7c in four glioma cell lines and a normal cell line by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and the results showed that let-7c was downregulated in glioma cells. By applying gain-of-function and loss-of-function assays, the experiments suggested More >

  • Open Access


    Upregulation of Long Noncoding RNA TUG1 Promotes Bladder Cancer Cell Proliferation, Migration, and Invasion by Inhibiting miR-29c

    Peng Guo*, Guohui Zhang*†, Jialin Meng, Qian He*, Zhihui Li, Yawei Guan

    Oncology Research, Vol.26, No.7, pp. 1083-1091, 2018, DOI:10.3727/096504018X15152085755247

    Abstract Bladder cancer (BC) is one of the leading causes of cancer-related deaths in the world. Long noncoding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) plays an important role in the development and progression of numerous cancers, including BC. However, the exact role of TUG1 in modulating BC progression is still poorly known. In this study, we found that TUG1 was upregulated and microRNA-29c (miR-29c) was downregulated in BC tissues and cell lines. Overexpression of TUG1 promoted the cell proliferation of T24 and EJ cells, whereas TUG1 knockdown had the opposite effect. Upregulation of TUG1 obviously facilitated… More >

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