Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086719 - 16 June 2026

Abstract This article has no abstract. More >

Kanyang Jiang¹, Yingkai Kang², Ming Li^2,*

CMC-Computers, Materials & Continua, Vol.88, No.2, 2026, DOI:10.32604/cmc.2026.083294 - 15 June 2026

Abstract The Internet of Vehicular Agents (IoVA) interconnects distributed AI agents across vehicular networks to deliver real-time intelligent services for vehicular users. Due to the limited computing capacity of vehicles, AI agents are deployed on nearby RoadSide Units (RSUs) to perform computation-intensive inference. As vehicles traverse RSU coverage boundaries, AI agents must migrate to target RSUs to maintain service continuity. However, the communication and computing resources at each RSU are shared among multiple co-served vehicles, creating coupled allocation decisions that jointly determine system latency and energy consumption. To address this challenge, we propose a low-latency and… More >

Kaidi Yin, Lili Deng, Wen Liu^*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075185 - 21 May 2026

Abstract Objectives: Although claudin-1 (CLDN1) interacts with Cluster of Differentiation 81 (CD81) in various cell types, the specific mechanism underlying this interaction and its functional implications in colorectal cancer (CRC) cells remain poorly understood. This study outlines the regulatory role of CLDN1 in CRC cell tumorigenicity through its interaction with CD81, elucidating the underlying signaling cascade. Methods: Changes in the expression of CLDN1 and CD81, as well as their correlation with the survival of CRC patients, were analyzed using samples from The Cancer Genome Atlas database, the Kaplan‒Meier plotter database, and tissue microarrays. CLDN1 and CD81 were… More >

Ralf Weiskirchen¹, Amedeo Lonardo^2,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076177 - 13 May 2026

Abstract Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver health differently. One significant cause of chronic liver diseases among those living with obesity is metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked to one or more cardiometabolic risk factors in individuals who do not engage in harmful alcohol consumption. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is increasingly being associated with MASLD through intricate immunological, cellular, proinflammatory, molecular, and genetic mechanisms. In this review, we More > Graphic Abstract

Navjeet Kaur¹, Ayush Mittal², Saad Alahmari^3,*

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.079991 - 08 May 2026

Abstract Mobile fog computing must support latency-sensitive applications under dynamic user mobility and time-varying network conditions. Existing mobility-aware scheduling approaches are largely reactive and often ignore prediction uncertainty, resulting in service disruptions and inefficient task migration. This paper proposes an uncertainty-aware digital twin-based orchestration framework for proactive mobility-aware fog computing. The framework maintains real-time synchronized digital twins of users and fog nodes and integrates a hybrid Gated Recurrent Unit-Exponentially Weighted Moving Average (GRU-EWMA) mobility prediction model with fog-load forecasting to enable joint mobility- and load-aware decision-making. An entropy-based confidence mechanism is introduced to regulate proactive handover More >

Xian Shi^1,2,*, Botao Zhang^1,2, Weidong Zhang^1,2, Zenghua Ma³, Bo Zhang³, Ahmad Ramezanzadeh⁴, Bin Li⁵, Jian Mao⁵

Energy Engineering, Vol.123, No.5, 2026, DOI:10.32604/ee.2025.073586 - 27 April 2026

Abstract To investigate the mechanism governing the continuous decline in fracture conductivity of unconsolidated sandstone reservoirs post-hydraulic fracturing, this study centers on the synergistic effects of two key mechanisms—particle migration and proppant embedment. Through the integration of laboratory experiments and computational fluid dynamics-discrete element method (CFD-DEM) coupled numerical simulations, this study systematically examines the influence patterns of varying closure pressures, particle concentrations, fluid properties, and proppant parameters on fracture conductivity. The experimental results demonstrate that particle migration induces pore blockage within the proppant packing layer. When the fines mass concentration reaches 10%, fracture conductivity is almost… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.081284 - 23 March 2026

Abstract This article has no abstract. More >

Yiran Dong¹, Jingyue Wang¹, Jiayang Chen², Liang Mo², Yong You^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.075191 - 23 March 2026

Abstract Background: Lung adenocarcinoma (LUAD), the most prevalent histological subtype of lung cancer, remains a leading cause of cancer-related mortality due to late diagnosis, metastasis, and therapy resistance. The aim of the study is to investigate the role of Kinetochore Scaffold 1 (KNL1) in promoting LUAD progression and its underlying molecular regulatory mechanisms. Methods: KNL1 mRNA expression levels across 33 cancer types were analyzed using bioinformatics analysis based on the TCGA database. Immunohistochemistry (IHC) was used to assess KNL1 expression in LUAD and normal tissues. Stable KNL1-knockdown and KNL1-overexpressing LUAD cell lines were established using lentiviral… More >

Crystal J. Byrd¹, Monasia Evans¹, Woojung Kim², Quintera Knight³, Geou-Yarh Liou^1,2,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073532 - 23 March 2026

Abstract Objective: The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment. Within this microenvironment, infiltrating immune cells, such as B cells, can be either anti-tumorigenic or pro-tumorigenic. Our preliminary data showed that a higher density of the infiltrating B cells was found near prostate cancer cells in human cancer tissues, as compared to the benign prostate tissue regions, thus suggesting that infiltrating B cells would promote the progression of prostate cancer cells. In this study, we aim to investigate the role of infiltrating B cells in enhancing the migratory ability of… More >

So-Ye Jeon^1,#, Zeeshan Ahmad Bhutta^1,#, Hong Kyu Lee², Kyung-Chul Choi^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.071328 - 23 March 2026

Abstract Objectives: Progesterone (P4) is believed to inhibit breast cancer growth, but its role in counteracting estrogen (E2)-driven progression remains unclear. This study aimed to investigate the inhibitory effect of P4 on E2-induced cell proliferation, migration, and invasion in Estrogen receptor (ER)+/progesterone receptor (PR)+ breast cancer cells by examining its regulatory role in the epithelial-mesenchymal transition (EMT). Methods: ER and PR-positive MCF-7 clonal variant (MCF-7 CV) breast cancer cells were treated with E2 and co-treated with various concentrations of P4. The effects on cell proliferation, migration, and invasion were assessed. The expression of key EMT markers… More >