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  • Open Access

    ARTICLE

    CLDN9 Levels Influence the Biological Activities of Cells in Gastric Cancer

    Jin Liu1,2, Xiu Zhang1, Xiao Hu2, Gaofeng Yuan2, Kai Chen1,*

    BIOCELL, Vol.49, No.4, pp. 665-680, 2025, DOI:10.32604/biocell.2025.063296 - 30 April 2025

    Abstract Objective: This study examines the significance and functions of CLDN9 in gastric cancer (GC), intending to identify novel targets for diagnosis and treatment. Methods: CLDN9 expression in GC tissues and cell lines was investigated in TCGA data, with analysis with Western blotting, qRT-PCR, and immunohistochemical analyses. Correlations between clinicopathological characteristics, progression-free survival (PFS), and overall survival (OS) were assessed with Cox regression. The effect of CLDN9 knockdown/overexpression on tumorigenic functions (proliferation, migration, and invasion) was assessed using CCK-8, colony formation, and Transwell assays. Tumor-bearing assays were performed to verify the impact of CLDN9 knockdown on… More >

  • Open Access

    RETRACTION

    Retraction: lncRNA FEZF1-AS1 Is Associated with Prognosis in Lung Adenocarcinoma and Promotes Cell Proliferation, Migration, and Invasion

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.5, pp. 1251-1252, 2025, DOI:10.32604/or.2025.065346 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Anticancer effects of SH003 and its active component Cucurbitacin D on oral cancer cell lines via modulation of EMT and cell viability

    HYEONG SIM CHOI1, JEONG-KUI KU1, SEONG-GYU KO2, PIL-YOUNG YUN1,3,*

    Oncology Research, Vol.33, No.5, pp. 1217-1227, 2025, DOI:10.32604/or.2025.059791 - 18 April 2025

    Abstract Background: Oral cancer remains a significant global health challenge, as it has high morbidity and mortality rates. Current treatments show limited efficacy and have severe side effects, prompting searches for new therapeutic agents. SH003, a traditional herbal formulation comprising Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, has demonstrated potential anticancer properties in previous studies. However, its specific efficacy against oral cancer and the role of its key components, particularly Cucurbitacin D, remain underexplored. Methods: The cytotoxic effects of SH003 and its major components—i.e., Cucurbitacin D, Decursin, Formononetin, and Nodakenin—were evaluated using 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT), Trypan Blue exclusion, and… More >

  • Open Access

    ARTICLE

    An Investigation into Dust Migration Patterns in Small-Section Tunnels and Large Steep-Sloped Inclined Shafts

    Baoli Zang1, Liyang Shao1, Yang Li1, Hao Ran2, Liangwen Wei2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.3, pp. 555-571, 2025, DOI:10.32604/fdmp.2024.054275 - 01 April 2025

    Abstract This study focuses on addressing ventilation and dust removal challenges during the construction of small-section tunnels using drilling and blasting techniques. Specifically, the research examines the shale gas gathering and transmission trunk line project in the Weiyuan and Luzhou blocks. To gain deeper insights into dust migration patterns, numerical simulations were conducted. The study further analyzed dust migration behavior in small-section tunnels and large steep-sloped shafts, taking into account various factors such as ventilation distance, tunnel slope, and section size. The results indicate that optimal ventilation occurs at distances of 15 and 13 m. Additionally, More >

  • Open Access

    ARTICLE

    Epibrassinolide Induces Apoptosis and Inhibits the Migration of Gastric Cancer AGS Cells by Regulating Reactive Oxygen Species-Mediated Signaling Pathways

    Chang Wang1,2,#, Zhi Zhang1,#, Wei Sun1, Quan Quan3, Wenshuang Hou3, Chenghao Jin1,3,4,*

    BIOCELL, Vol.49, No.3, pp. 465-482, 2025, DOI:10.32604/biocell.2025.062155 - 31 March 2025

    Abstract Objectives: Epibrassinolide (EBR) is a steroid hormone with anti-tumor properties. Nevertheless, its potential to inhibit gastric cancer (GC) cells remains unknown. The aim of this research was to examine the effects of EBR on GC cells and to investigate the specific mechanism of EBR. Methods: A cell counting kit-8 (CCK-8) assay was utilized to determine cell survival rates. The investigation of apoptosis, cell cycle progression, and reactive oxygen species (ROS) levels was performed using flow cytometry. To detect cell migration, a wound-healing assay was performed on AGS cells. Furthermore, western blotting assay was utilized to determine… More >

  • Open Access

    ARTICLE

    ARPC1A Promotes NSCLC Malignancy via Stimulating the Drug Resistance and Cell Migration

    Hongjuan Guo1, Dan Liu1,2, Ruyu Yan1,2, Tianjing Zhang3, Kecheng Zhou1,2,*, Minxia Liu1,*

    BIOCELL, Vol.49, No.3, pp. 483-502, 2025, DOI:10.32604/biocell.2025.062143 - 31 March 2025

    Abstract Objectives: Non-small cell lung cancer (NSCLC) represents a formidable malignancy characterized by its marked metastatic potential and intrinsic resistance to therapeutic interventions. The identification of potential biomarkers delineating the progression and metastatic cascade of NSCLC assumes paramount importance in fostering advancements toward enhanced patient outcomes and prognostic stratification. Methods: The expression level of the actin-related protein 2/3 complex; subunit 1A (ARPC1A) in NSCLC was evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases; along with the LinkedOmics database for co-expression genes. Further verification of ARPC1A expression in normal lung cells… More >

  • Open Access

    RETRACTION

    Retraction: Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.4, pp. 991-991, 2025, DOI:10.32604/or.2024.056914 - 19 March 2025

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    An Enhanced Task Migration Technique Based on Convolutional Neural Network in Machine Learning Framework

    Hamayun Khan1,*, Muhammad Atif Imtiaz2, Hira Siddique3, Muhammad Tausif Afzal Rana4, Arshad Ali5, Muhammad Zeeshan Baig6, Saif ur Rehman7, Yazed Alsaawy5

    Computer Systems Science and Engineering, Vol.49, pp. 317-331, 2025, DOI:10.32604/csse.2025.061118 - 19 March 2025

    Abstract The migration of tasks aided by machine learning (ML) predictions IN (DPM) is a system-level design technique that is used to reduce energy by enhancing the overall performance of the processor. In this paper, we address the issue of system-level higher task dissipation during the execution of parallel workloads with common deadlines by introducing a machine learning-based framework that includes task migration using energy-efficient earliest deadline first scheduling (EA-EDF). ML-based EA-EDF enhances the overall throughput and optimizes the energy to avoid delay and performance degradation in a multiprocessor system. The proposed system model allocates processors… More >

  • Open Access

    ARTICLE

    ANLN Promotes Cervical Cancer Cell Proliferation, Migration and Invasion and Suppresses Apoptosis via the Wnt/β-Catenin Pathway

    Lingling Zhang1,2, Hualing Wang3, Yawen Liu2, Ling Li2,*, Jianping Xiong1,4,*

    BIOCELL, Vol.49, No.2, pp. 253-267, 2025, DOI:10.32604/biocell.2025.061585 - 28 February 2025

    Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >

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