Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086727 - 16 June 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086722 - 16 June 2026

Abstract This article has no abstract. More >

Moo Hyun Kim¹, Yongdae Yoon², Chang Wan Kim¹, Jun-Won Lee³, Bhupendra Regmi², Saher Fatima², Moon Young Kim^2,3, Soon Koo Baik^2,3, Pil Young Jung^1,*, Young Woo Eom^2,*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.076364 - 09 June 2026

Abstract Background: Although transforming growth factor-β (TGF-β) drives hepatic stellate cell activation and fibrogenesis, the mechanisms by which 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates these processes in TGF-β1-activated hepatic stellate cells remain to be determined. Therefore, we investigated whether TPA alleviates fibrosis in TGF-β1-treated hepatic stellate cells and regulates both canonical and non-canonical pathways. Further, we assessed whether inhibitors of these pathways similarly affect proliferation and fibrosis in LX-2 cells. Methods: LX-2 hepatic stellate cells were used as the experimental model. Cells were treated with TPA, TGF-β, or TGF-β plus TPA, and Yes-associated protein (YAP) and protein kinase B (PKB;… More >

Junming Yan, Boran Xiong, Yingjie Zhu^*

BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.075319 - 09 June 2026

Abstract Objective: Neural stem cells (NSCs) are essential for replenishing nerve cells, providing neuroprotection, and repairing damaged brain function, while mitophagy is critical for maintaining NSCs’ homeostasis. The study investigated whether pyruvate kinase M2 (PKM2) regulates NSCs’ proliferation and differentiation by modulating mitophagy. Method: This study established a model of excessive autophagy in neural stem cell mitochondria induced by cobalt chloride (CoCl₂) and used plasmid transfection technology to knock down PKM2 expression, examining its effects on NSCs proliferation and differentiation. Additionally, potential mechanisms were explored by overexpressing phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and adding the… More > Graphic Abstract

Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085239 - 21 May 2026

Abstract This article has no abstract. More >

Boqi Zhou^1,2,3, Liping Shen^2,3, Xiaojie Lu^1,2,3,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.079463 - 21 May 2026

Abstract Objectives: Gamma-aminobutyric acid type B (GABAB) receptors are involved in tumor progression, and baclofen exerts broad-spectrum antitumor effects in various cancers. Nevertheless, its specific function and underlying molecular mechanisms in glioma are still largely unclear. This study aimed to evaluate the effects of baclofen on glioma cells and elucidate the associated signaling pathways. Methods: The antitumor effects of baclofen were evaluated in glioma cell lines, and its underlying molecular mechanisms were explored using transcriptome sequencing integrated with Western blotting. The in vivo antitumor efficacy of baclofen was further verified in animal models. Results: In vitro functional assays revealed that… More >

Ralf Weiskirchen¹, Amedeo Lonardo^2,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076177 - 13 May 2026

Abstract Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver health differently. One significant cause of chronic liver diseases among those living with obesity is metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked to one or more cardiometabolic risk factors in individuals who do not engage in harmful alcohol consumption. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is increasingly being associated with MASLD through intricate immunological, cellular, proinflammatory, molecular, and genetic mechanisms. In this review, we More > Graphic Abstract

Oncology Research Editorial Office

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.081623 - 22 April 2026

Abstract This article has no abstract. More >

Jun Jiang^1,#, Yi-Ran Li^2,#, Xiaoting Wang^3,#, Jian Li¹, Fangzhou Ye¹, Jiayi Wang¹, Huanqing Li^1,*, Li Feng^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076051 - 22 April 2026

Abstract Background: In various tumor types, cell division cycle-associated 7 (CDCA7) is involved in chromatin remodeling and DNA methylation. However, its biological functions and regulatory mechanisms in gastric cancer (GC) remain unknown. This investigation intended to identify the function of CDCA7 in GC progression and elucidate its epigenetic regulatory mechanisms. Methods: Differentially expressed genes (DEGs) were detected from the GSE19826, TCGA-GC, and GSE56807 datasets. Networks of protein-protein interactions (PPI) and hub genes were discovered by the DMNC and Clustering Coefficient algorithms. Receiver operating characteristic (ROC) analysis and expression profiling were undertaken to determine diagnostic performance. In vitro assays,… More >

Yan Wang^1,#, Jialei Zhu^2,#, Shiyang Wei^3,4,#, Lijie Jin¹, Zhanqiu Liu¹, Jie Xu¹, Nana Yang¹, Xuefeng Jiang⁴, Caizhi Wang^1,*, Lingling Wang^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.068833 - 22 April 2026

Abstract Background: The role of 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) in endometrial cancer (EC) progression remains poorly understood, particularly its involvement in metabolic-epigenetic crosstalk via lactate-driven histone lactylation. This study aimed to investigate HPDL’s mechanistic contribution to EC pathogenesis. Methods: Stable HPDL-overexpressing and knockdown EC cell lines (HEC-1-B and AN3CA) were generated using lentiviral vectors. Functional assays (proliferation, migration, invasion), subcutaneous xenograft models in BALB/c nude mice, and molecular analyses were conducted. Lactate levels, Pan-lysine lactylation (pan-kla), histone H3K18 lactylation (H3K18la), and effects of sodium oxamate (lactate modulator) were assessed. Lactate Dehydrogenase A/Lactate Dehydrogenase B (LDHA/LDHB) knockdown,… More >