Jin Liu1,2, Xiu Zhang1, Xiao Hu2, Gaofeng Yuan2, Kai Chen1,*
BIOCELL, Vol.49, No.4, pp. 665-680, 2025, DOI:10.32604/biocell.2025.063296
- 30 April 2025
Abstract Objective: This study examines the significance and functions of CLDN9 in gastric cancer (GC), intending to identify novel targets for diagnosis and treatment. Methods: CLDN9 expression in GC tissues and cell lines was investigated in TCGA data, with analysis with Western blotting, qRT-PCR, and immunohistochemical analyses. Correlations between clinicopathological characteristics, progression-free survival (PFS), and overall survival (OS) were assessed with Cox regression. The effect of CLDN9 knockdown/overexpression on tumorigenic functions (proliferation, migration, and invasion) was assessed using CCK-8, colony formation, and Transwell assays. Tumor-bearing assays were performed to verify the impact of CLDN9 knockdown on… More >