Oncology Research Editorial Office

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.081623 - 22 April 2026

Abstract This article has no abstract. More >

Jun Jiang^1,#, Yi-Ran Li^2,#, Xiaoting Wang^3,#, Jian Li¹, Fangzhou Ye¹, Jiayi Wang¹, Huanqing Li^1,*, Li Feng^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076051 - 22 April 2026

Abstract Background: In various tumor types, cell division cycle-associated 7 (CDCA7) is involved in chromatin remodeling and DNA methylation. However, its biological functions and regulatory mechanisms in gastric cancer (GC) remain unknown. This investigation intended to identify the function of CDCA7 in GC progression and elucidate its epigenetic regulatory mechanisms. Methods: Differentially expressed genes (DEGs) were detected from the GSE19826, TCGA-GC, and GSE56807 datasets. Networks of protein-protein interactions (PPI) and hub genes were discovered by the DMNC and Clustering Coefficient algorithms. Receiver operating characteristic (ROC) analysis and expression profiling were undertaken to determine diagnostic performance. In vitro assays,… More >

Yan Wang^1,#, Jialei Zhu^2,#, Shiyang Wei^3,4,#, Lijie Jin¹, Zhanqiu Liu¹, Jie Xu¹, Nana Yang¹, Xuefeng Jiang⁴, Caizhi Wang^1,*, Lingling Wang^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.068833 - 22 April 2026

Abstract Background: The role of 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) in endometrial cancer (EC) progression remains poorly understood, particularly its involvement in metabolic-epigenetic crosstalk via lactate-driven histone lactylation. This study aimed to investigate HPDL’s mechanistic contribution to EC pathogenesis. Methods: Stable HPDL-overexpressing and knockdown EC cell lines (HEC-1-B and AN3CA) were generated using lentiviral vectors. Functional assays (proliferation, migration, invasion), subcutaneous xenograft models in BALB/c nude mice, and molecular analyses were conducted. Lactate levels, Pan-lysine lactylation (pan-kla), histone H3K18 lactylation (H3K18la), and effects of sodium oxamate (lactate modulator) were assessed. Lactate Dehydrogenase A/Lactate Dehydrogenase B (LDHA/LDHB) knockdown,… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.081287 - 23 March 2026

Abstract This article has no abstract. More >

Shanbao Ke, Junya Yan, Xiao Feng, Baiyu Li^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.071617 - 23 March 2026

Abstract Objectives: Tumor recurrence is a major determinant of poor prognosis in hepatocellular carcinoma (HCC), yet its cellular and molecular basis remains incompletely understood. This study aimed to identify recurrence-associated genes at single-cell resolution and to develop a prognostic model for predicting survival outcomes and immunotherapy responsiveness in HCC. Methods: Single-cell RNA sequencing data from 12 primary and 6 recurrent HCC samples were integrated and analyzed to identify genes characteristic of recurrence. After quality control, principal component analysis, and t-SNE-based clustering were used to identify highly variable genes for cell clustering and annotation. Based on macrophage… More >

Yanfeng Wang^1,2,#, Xinyi Chen^1,2,#, Yichen Yin^1,2, Tao Li^3,*, Jing Chen^1,2,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.068695 - 24 February 2026

Abstract Objectives: B-cell lymphoma 6 (BCL6) is a transcriptional repressor whose overexpression is closely linked to the progression of diffuse large B-cell lymphoma (DLBCL), making it a promising therapeutic target. This study aims to identify a novel small molecule, synthesized via proteolysis-targeting chimeras (PROTACs), capable of degrading BCL6, thereby inhibiting DLBCL growth and providing a foundation for future preclinical studies. Methods: The expression of BCL6 in DLBCL was analyzed using The Cancer Genome Atlas (TCGA) database and the Human Protein Atlas. Western blotting assays confirmed BCL6 expression in tumor cell lines, leading to the identification of… More >

Min Dong^1,#, Zongchang Song^2,#, Xiaohui Lu^1,3,#, Minxue Lu^4,*, Chen Zhong^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.068508 - 24 February 2026

Abstract Background: Gastric cancer (GC) remains highly lethal, with metabolic reprogramming as a key hallmark. This study explores Centromere Protein F (CENPF)’s role in GC pathogenesis, specifically its regulation of glutamine metabolism. Methods: The Cancer Genome Atlas–Stomach Adenocarcinoma (TCGA-STAD), GSE19826, and GSE27342 datasets were analyzed by bioinformatics to identify key candidate genes in GC. The function of CENPF was assessed by flow cytometry, colony formation assays, and Cell Counting Kit-8 (CCK-8). RNA sequencing, metabolic profiling, chromatin immunoprecipitation (ChIP), western blot (WB), and luciferase reporter assay were employed to investigate the fundamental mechanisms. Results: CENPF was upregulated in GC… More >

Jianfeng Wang^#, Zhongqing Hu^#, Jiandong Guo, Xin Jin, Lei Cai, Jian Li, Jinxi Zhang^*, DONGAN HE^*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.072227 - 14 February 2026

Abstract Objectives: Therapeutic strategies for enhancing bone regeneration and combating osteoporosis remain a significant unmet medical need. This study aims to elucidate Lithospermic acid (LA)’s regulatory effects on osteoblast proliferation and differentiation, investigating its viability as a bone-healing agent. Methods: This study employed various cellular and molecular biology experiments to assess the effects of LA on the viability, proliferation, cell cycle, apoptosis, differentiation, mineralization, and migration of MC3T3-E1 osteoblasts. Immunofluorescence and Western blot analyses were conducted to detect the expression of proteins related to the Wnt/β-catenin signaling pathway, investigating the regulatory mechanisms by which LA promotes… More > Graphic Abstract

Hang Zhang^1,#, Meng-Yuan Chu^1,#, Guohui Lv¹, You-Jie Li¹, Xuhang Liu², Fei Jiao^1,*, Yun-Fei Yan^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068322 - 23 January 2026

Abstract Objectives: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited understanding of lncRNA-driven mechanisms in tumor progression. This study aimed to identify differentially expressed lncRNAs in NSCLC tissues and elucidate the functional role of the significantly upregulated RP3-340N1.2 in promoting malignancy. Methods: RNA sequencing was used to screen dysregulated lncRNAs. RP3-340N1.2 was functionally characterized via gain/loss-of-function assays in NSCLC cells, assessing proliferation, migration, and macrophage polarization. Mechanisms of interleukin 6 (IL-6) regulation were explored using cytokine profiling, Actinomycin D assays, and RNA Immunoprecipitation (RIP) assays to study RP3-340N1.2 interactions with… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

Abstract This article has no abstract. More >