Home / Journals / ONCOLOGIE / Vol.22, No.4, 2020
  • Open Access

    EDITORIAL

    Specificities of Ophthalmic Tumors: Usefulness of A National Network
    Spécificités des Tumeurs de la Sphère Ophtalmique: Utilité d’un Réseau National

    Laurence Desjardins*
    Oncologie, Vol.22, No.4, pp. 189-194, 2020, DOI:10.32604/oncologie.2020.012377
    Abstract We describe the most frequent malignant intraocular tumors, conjunctival tumors and some lids and orbital tumors. Primary intraocular malignant tumors are retinoblastoma in children and uveal melanoma in adults. For uveal melanoma, the liver is the most frequent site of metastasis and this is why it is justified to prescribe liver ultrasonography every 6 months to these patients. Metastatic tumors can occur in the uvea and more frequently in the posterior part called the choroid. They are more frequent after breast cancer and lung cancer. Conjunctival tumors can be epithelial (benign papillomas and epidermoid carcinomas) or melanocytic (benign naevi and… More >

  • Open Access

    ARTICLE

    Pathological Examination: Features of Ocular Tumors
    Examen Anatomopathologique: Particularités des Tumeurs Oculaires

    Sophie Gardrat*, Vincent Cockenpot
    Oncologie, Vol.22, No.4, pp. 195-202, 2020, DOI:10.32604/oncologie.2020.013698
    Abstract The pathological examination of ocular tumors has specificities in terms of macroscopic management, microscopic analysis, and molecular examinations requiring special attention. We discuss here the difficulties encountered in the reception in the pathological anatomy laboratory of conjunctival samples, enucleation and orbital exenteration pieces, then detail the diagnostic and theranostic, microscopic and molecular characteristics of ocular tumor pathologies. Conjunctival tumors (epithelial, melanocytic and lymphoid), choroidal tumors (including uveal melanoma) and retinoblastoma are treated. Because of their low frequency and their features, these tumors should be the subject of anatomo-clinical discussions.

    Résumé:
    L’examen anatomopathologique des tumeurs oculaires comporte des spécificités en termes… More >

  • Open Access

    ARTICLE

    Uveal Melanoma Management for Medical Oncologists in 2020
    Prise en charge du mélanome uvéal en oncologie médicale en 2020

    Sophie Piperno-Neumann1,*, Pascale Mariani2, Vincent Servois3, Gaelle Pierron4, Livia LumbrosoRouic5, Alexandre Matet5,6, Manuel Rodrigues1, Nathalie Cassoux5,6
    Oncologie, Vol.22, No.4, pp. 203-212, 2020, DOI:10.32604/oncologie.2020.014102
    Abstract Uveal melanoma is a rare subtype of melanoma, intrinsically different from cutaneous melanoma. Despite optimal therapeutic management allowing local control of the primary ocular tumor, 20 to 50% of patients develop metastases, mainly localized to the liver, with a poor prognosis and a 12-month median survival from the diagnosis of the metastatic disease. There is a lack of effective treatments in the metastatic setting, and dedicated strategies and trials for uveal melanoma patients are needed, based on identification of new targets and specific preclinical findings.


    Résumé:
    Le mélanome de l’uvée est un cancer rare, en tous points différent du mélanome… More >

  • Open Access

    REVIEW

    Dietary Inclusions and Exclusions: Preparation Against Cancer

    Dheeraj Kumar Sharma1, Ahsas Goyal2,*, Shashank Chaturvedi2,*
    Oncologie, Vol.22, No.4, pp. 213-224, 2020, DOI:10.32604/oncologie.2020.014926
    Abstract Cancer results due to an imbalance between regulation of cell proliferation and apoptosis. As per the latest data released by World Health Organization (WHO), a large part of global population cannot access proper anticancer therapy, and this imposes a burden of approximately US$ 1.16 trillion on global economy. Relevant studies were identified through electronic searches of Pubmed, Medline, Scopus, Google scholar. In this review, we found that there is extensive range of dietary items whose components can influence either cell proliferation rate or cell death rate or both. Exclusion and avoidance of several dietary items/habits are linked with reduced risk… More >

  • Open Access

    ARTICLE

    The Investigation of Genotype-Phenotype Relationship in Multiple Primary Malignant Neoplasia Patients

    Neslihan Duzkale1,*, Emine Demıral2
    Oncologie, Vol.22, No.4, pp. 225-234, 2020, DOI:10.32604/oncologie.2020.014120
    Abstract Multiple primary malignant neoplasms (MPMN) are rare tumors that have attracted attention with increasing incidence rates in recent years and where cancer susceptibility genes may play a role in their etiology. In this study, it was aimed to determine the genotype-phenotype correlation in patients with MPMN. From January 2018 to January 2020, thirty patients were analyzed for 59 cancer susceptibility genes and diagnosed with MPMN, using a large multigene panel with Next Generation Sequencing technique (NGS) in Turkey. The mean age of first and second cancer diagnosis of cases were calculated as 42.5 and 49.9 (respectively). These primary cancers were… More >

  • Open Access

    ARTICLE

    Analysis on Characteristics and Nursing Points of Surgical and Interventional Treatment for Elderly Cerebral Aneurysm

    Haiying You1, Jing Li2, Xiaojie Wang3, Guodong Zhang4, Juan Yang5,*
    Oncologie, Vol.22, No.4, pp. 235-244, 2020, DOI:10.32604/oncologie.2020.014123
    Abstract Objective. The purpose was to explore the characteristics and nursing points of surgical and interventional treatment for elderly cerebral aneurysm. Methods. 100 elderly patients with cerebral aneurysm treated in our hospital from January 2017 to December 2019 were selected, and divided into craniotomy group (40 patients with neurosurgical clipping) and interventional surgery group (60 patients with endovascular interventional embolization) according to the treatment method to compare the operation time, hospitalization time, hospitalization expenses, degree of brain injury, complications and prognostic scores of the patients in two groups. Meanwhile, the relationship between the factors (age, aneurysm size, location) and prognosis of… More >

  • Open Access

    ARTICLE

    LncRNA-ATB Can Be a Biomarker for Diagnosis and Prognosis Evaluation of Non-Small Cell Lung Cancer

    Nan Geng1, Wenxia Hu1, Zhikun Liu2, Jingwei Su2, Wenyu Sun3, Shaonan Xie4, Cuimin Ding1,*
    Oncologie, Vol.22, No.4, pp. 245-254, 2020, DOI:10.32604/oncologie.2020.014125
    Abstract Objective: This study was set out to inquire into the expression and clinical significance of lncRNA activated by transforming growth factor β (LncRNA-ATB) and in cancer tissues of patients with non-small cell lung cancer (NSCLC). Methods: LncRNA-ATB in cancer tissues and adjacent tissues of 89 NSCLC patients was detected by quantitative real-time polymerase chain reaction (qRT-PCR), and its clinical diagnostic value in NSCLC was determined by receiver operating characteristic (ROC) curves. Based on the median expression of LncRNAATB in NSCLC tissues, 89 patients were allocated into high- and low-expression groups. The 3-year survival rate was calculated using Kaplan-Meier method and… More >

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