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Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma

Xingyu Zhu1,2,#, Yongjun Wang3,#, Shuang Chang4,#, Yue Su2, Cuixia He1, Shuang Hu5, Minhui Zhu1, Yuzhou Ding2, Nuannuan Ren2, Qizhi Wang2, Jing Xie1,*, Huan Zhou1,2,*

1 National Drug Clinical Trial Center, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233000, China
2 School of Pharmacy, Bengbu Medical College, Bengbu, 233000, China
3 School of Design, Hefei University, Hefei, 230601, China
4 The Affiliated Anqing Hospital of Anhui Medical University, Anqing, 230022, China
5 School of Pharmacy, Anhui Medical University, Hefei, 230032, China
# Xingyu Zhu, Yongjun Wang and Shuang Chang contributed equally to this work

* Corresponding Authors:Jing Xie. Email: ; Huan Zhou. Email:

Oncologie 2021, 23(4), 569-588.


Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function of SIRTs in HCC and evaluates SIRTs as new targets for HCC treatment.


Cite This Article

Zhu, X., Wang, Y., Chang, S., Su, Y., He, C. et al. (2021). Epigenetics of Sirtuins: Relevance to Hepatocellular Carcinoma. Oncologie, 23(4), 569–588.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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