S.R. MANE^1,2, E. K. PATHAN³, G. PATIL⁴, S. G. TUPE⁵, V. GHORMADE⁴, B. P. CHAUDHARI^1,2, M.V. DESHPANDE^5,*

Journal of Polymer Materials, Vol.38, No.3-4, pp. 219-230, 2021, DOI:10.32381/JPM.2021.38.3-4.4

Abstract A dimorphic fungus Benjaminiella poitrasii contains high chitin/chitosan (35% of the cell wall) in the mycelial (M) form than its yeast (Y) form (20% of the cell wall). However, the relative proportion of chitosan is more in yeast form cells (chitosan: chitin ratio, 6:1) than mycelial cells (chitosan: chitin ratio, 3:1). Using the Taguchi design of experimental (DOE) approach, interactions among eight different parameters showed that carbon source (starch, 10 g/L), incubation time (48 h), inoculum (M and Y mixed 10%), yeast extract (6 g/L) and peptone (10 g/L), were optimum for maximum biomass production. Under these conditions, the chitosan… More >

ASPASIA MANTA¹, SPYRIDON KAZANAS², STEFANOS KARAMAROUDIS³, HELEN GOGAS², DIMITRIOS C. ZIOGAS^2,*

Oncology Research, Vol.30, No.5, pp. 211-219, 2022, DOI:10.32604/or.2022.026913

Abstract Epigenetic mechanisms, such as DNA methylation and histone modifications (e.g., acetylation and deacetylation), are strongly implicated in the carcinogenesis of various malignancies. During transcription, the expression and functionality of coding gene products are altered following the histone acetylation and deacetylation. These processes are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. HDAC inhibitors (HDACis) have been developed as promising therapeutic agents, to limit exposure to traditional and toxic chemotherapies and offer more alternatives for some specific malignant diseases with limited options. Mechanistically, these agents affect many intracellular pathways, including cell cycle arrest, apoptosis and differentiation, and their mechanism… More >

Che Engku Noramalina Che Engku Chik¹, Amyra Suryatie Kamaruzzan¹, Ahmad Ideris Abdul Rahim¹, Fathurrahman Lananan^2,3, Azizah Endut⁴, Siti Aslamyah⁵, Nor Azman Kasan^1,*

Journal of Renewable Materials, Vol.11, No.3, pp. 1181-1197, 2023, DOI:10.32604/jrm.2023.022755

Abstract Chitin is the second most abundant polysaccharide, produced mainly as an industrial waste stream during crustacean processing. Chitin can be derived into chitosan through the deacetylation process. Conversion of shrimp waste into chitosan via the deacetylation process could be considered a practical approach for shell waste remediation. In this study, chitosan’s physicochemical characteristics extracted from two types of Pacific white leg shrimp, L. vannamei’s shell (i.e., rough and smooth), were compared with commercial chitosan. The yield, moisture, ash, solubility, water and fat binding capacity were measured. The degree of deacetylation (DDA) was calculated using FTIR, and their chemical Structure was… More > Graphic Abstract

Xingyu Zhu^1,2,#, Yongjun Wang^3,#, Shuang Chang^4,#, Yue Su², Cuixia He¹, Shuang Hu⁵, Minhui Zhu¹, Yuzhou Ding², Nuannuan Ren², Qizhi Wang², Jing Xie^1,*, Huan Zhou^1,2,*

Oncologie, Vol.23, No.4, pp. 569-588, 2021, DOI:10.32604/oncologie.2021.018869

Abstract Sirtuins (SIRTs), members of the enzyme family found in yeast cells, are related to silent information regulator (SIR) 2 homologous to its gene family. SIRTs play an important role in many physiological functions from overexpression of gene silencing at the molecular level to the expression of related proteins and RNA to apoptosis. Studies have indicated that SIRTs may be related to the occurrence, development, and metastasis of cancer. However, the current mechanism of action of SIRTs in various diseases and the principle of molecular biology are not fully understood. Therefore, the present article discusses the main regulatory role and function… More >

Malinda Syifa Yusharani, Stenley, Harmami, Ita Ulfin, Suprapto Suprapto, Yatim Lailun Ni’mah*

Journal of Renewable Materials, Vol.7, No.7, pp. 643-653, 2019, DOI:10.32604/jrm.2019.04185

Abstract Water-Soluble Chitosan (WSC) has been sucessfuly synthesized from squid pens waste. The synthesis of chitosan from chitin was carried out by optimization of deacetylation temperature and time. Chitin was obtained from squid pens waste by demineralization and deproteinization process. HCl 7% was used for demineralization and NaOH 10% at 60°C was applied for deproteinization process. Deacetylation reaction was carried out at varied temperatures i.e., 60°C, 70°C, 80°C, 90°C and 100°C in NaOH 50% solution for 10 hours. Deacetylation reaction time were varied for 2 hours, 4 hours, 6 hours, 8 hours, and 10 hours. The crude chitosan obtained then reacted… More >