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REVIEW

The Effect of Oncogene Proteins of Human Papillomaviruses on Apoptosis Pathways in Prostate Cancer

Robabeh Faghani Baladehi1,2, Mohammad Yousef Memar1, Abolfazl Jafari Sales3, Ahad Bazmani1,4, Javid Sadri Nahand1,5,6, Parisa Shiri Aghbash2,7, Hossein Bannazadeh Baghi1,2,7,*

1 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Microbiology, Faculty of Medical Sciences, Islamic Azad University, Kazerun, Iran
4 Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
6 Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
7 Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

* Corresponding Authors: Hossein Bannazadeh Baghi. Emails: email; email

Oncologie 2022, 24(2), 227-245. https://doi.org/10.32604/oncologie.2022.020648

Abstract

The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping cells eliminate viruses. Human papillomaviruses (HPV) activate several pathways, enabling the infected cells to avoid extrinsic and intrinsic apoptosis pathways. The incapacity of prostatic epithelial cells to induce apoptosis leads to the invasive development of prostate cancer. For the pathogenesis of prostate cancer, several risk factors have been reported; for example, some viruses and infectious diseases have been proposed as causative agents for their relation to prostate diseases. According to several studies, high-risk human papillomaviruses cause malignancy by interfering with the apoptotic and inflammatory pathways; these viruses, such as HPV16 and HPV18, block apoptotic pathways and result in prostate cancer. This review is dedicated to presenting a summary of oncogenes (E5, E6, and E7) HR-HPVs’ functions on signaling pathways, inflammation in prostate tumorigenesis, and emphasizing the link between these oncogenes with apoptosis and prostate cancer.

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Cite This Article

APA Style
Baladehi, R.F., Memar, M.Y., Sales, A.J., Bazmani, A., Nahand, J.S. et al. (2022). The effect of oncogene proteins of human papillomaviruses on apoptosis pathways in prostate cancer. Oncologie, 24(2), 227-245. https://doi.org/10.32604/oncologie.2022.020648
Vancouver Style
Baladehi RF, Memar MY, Sales AJ, Bazmani A, Nahand JS, Aghbash PS, et al. The effect of oncogene proteins of human papillomaviruses on apoptosis pathways in prostate cancer. Oncologie . 2022;24(2):227-245 https://doi.org/10.32604/oncologie.2022.020648
IEEE Style
R.F. Baladehi et al., "The Effect of Oncogene Proteins of Human Papillomaviruses on Apoptosis Pathways in Prostate Cancer," Oncologie , vol. 24, no. 2, pp. 227-245. 2022. https://doi.org/10.32604/oncologie.2022.020648



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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