Open Access
ARTICLE
Development and Validation of a Nomogram Model to Predict the Prognosis of Intrahepatic Cholangiocarcinoma
Yi Chen1,#, Liyun Huang1,#, Zuwu Wei1, Xiaoling Liu1, Lihong Chen1,2,*, Bin Wang1,2,*
1
Department of Pathology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
2
Department of Pathology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China
* Corresponding Authors: Lihong Chen. Email: ; Bin Wang. Email:
# Yi Chen and Liyun Huang contributed equally to this work
Oncologie 2022, 24(2), 329-340. https://doi.org/10.32604/oncologie.2022.022521
Received 16 March 2022; Accepted 19 May 2022; Issue published 29 June 2022
Abstract
Background: The effective method for predicting prognosis of ICC is still lack. This study aims to establish and
verify an effective prognostic nomogram model for intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy.
Materials and Methods: A nomogram model was developed in a cohort of 127 patients from January
2015 to December 2019. General clinical characteristics including preoperative physical examination data and
postoperative pathological features were obtained. The independent risk factors identified by univariate and multivariate COX proportional hazards regression models were used to construct nomogram model. Predictive accuracy and discriminative ability were determined using a concordance index and a calibration curve. In addition,
the clinical significance of postoperative pathological subtypes was analyzed by Kaplan-Meier survival analysis.
Results: Univariate analysis and multivariate COX regression analysis revealed that CEA, maximum diameter,
tumor number, and large duct type ICC was the independent risk factors. These variables were incorporated into
the nomogram and the C-index for one year and three year overall survival prediction was 0.765 (95% CI:
0.672–0.814) and 0.695 (95% CI: 0.672–0.814), respectively. Postoperative pathological analysis showed that
the large duct ICC had a distinct clinicopathological features and poor outcome.
Conclusion: The proposed
nomogram enables a prognostic prediction for patients with ICC and postoperative subclassification of ICC is
of great significant to the prognosis of ICC.
Keywords
Cite This Article
APA Style
Chen, Y., Huang, L., Wei, Z., Liu, X., Chen, L. et al. (2022). Development and validation of a nomogram model to predict the prognosis of intrahepatic cholangiocarcinoma. Oncologie, 24(2), 329-340. https://doi.org/10.32604/oncologie.2022.022521
Vancouver Style
Chen Y, Huang L, Wei Z, Liu X, Chen L, Wang B. Development and validation of a nomogram model to predict the prognosis of intrahepatic cholangiocarcinoma. Oncologie . 2022;24(2):329-340 https://doi.org/10.32604/oncologie.2022.022521
IEEE Style
Y. Chen, L. Huang, Z. Wei, X. Liu, L. Chen, and B. Wang "Development and Validation of a Nomogram Model to Predict the Prognosis of Intrahepatic Cholangiocarcinoma," Oncologie , vol. 24, no. 2, pp. 329-340. 2022. https://doi.org/10.32604/oncologie.2022.022521