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PD-L1 Induces Epithelial–Mesenchymal Transition in Nasopharyngeal Carcinoma Cells Through Activation of the PI3K/AKT Pathway

Zhenghua Fei*1, Zhenxiang Deng†1, Lingyang Zhou, Kejie Li*, Xiaofang Xia*, Raoying Xie*

* Department of Radiation and Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, P.R. China
† Department of Radiation Oncology, Xiang’an Hospital of Xiamen University, Fujian, P.R. China
‡ Department of General Surgery, Yongjia County Traditional Chinese Medicine Hospital, Zhejiang, P.R. China

Oncology Research 2019, 27(7), 801-807. https://doi.org/10.3727/096504018X15446984186056

Abstract

Nasopharyngeal cancer (NPC) is a malignant epithelial carcinoma of the head and neck. Cancer therapy targeting programmed cell death protein-1 (PD-1) or programmed death ligand-1 (PD-L1) is revolutionary. However, the tumorigenic mechanism of PD-L1 is not yet clear in NPC. Here we demonstrated an oncogenic role of PD-L1 via activating PI3K/AKT in NPC cells. PD-L1 overexpression was frequently detected in NPC biopsies and cell lines by qRT-PCR. PD-L1 overexpression and knockdown demonstrated that PD-L1 promoted NPC cell invasion and metastasis in vitro and in vivo. Mechanistically, PD-L1 prominently activated the epithelial–mesenchymal transition (EMT) process in a PI3K/AKT-dependent manner. Taken together, we found that PD-L1 overexpression confers NPC cell malignancy and aggressiveness via activating the downstream PI3K/AKT signaling. Thus, these results provide a basis for diagnosis and treatment of NPC.

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APA Style
Fei, Z., Deng, .Z., Zhou, .L., Li, K., Xia, X. et al. (2019). PD-L1 induces epithelial–mesenchymal transition in nasopharyngeal carcinoma cells through activation of the PI3K/AKT pathway. Oncology Research, 27(7), 801-807. https://doi.org/10.3727/096504018X15446984186056
Vancouver Style
Fei Z, Deng Z, Zhou L, Li K, Xia X, Xie R. PD-L1 induces epithelial–mesenchymal transition in nasopharyngeal carcinoma cells through activation of the PI3K/AKT pathway. Oncol Res. 2019;27(7):801-807 https://doi.org/10.3727/096504018X15446984186056
IEEE Style
Z. Fei, .Z. Deng, .L. Zhou, K. Li, X. Xia, and R. Xie "PD-L1 Induces Epithelial–Mesenchymal Transition in Nasopharyngeal Carcinoma Cells Through Activation of the PI3K/AKT Pathway," Oncol. Res., vol. 27, no. 7, pp. 801-807. 2019. https://doi.org/10.3727/096504018X15446984186056



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