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  • Open Access


    High-Value-Added Utilization of Turpentine: Screening of Anti-Influenza Virus Agents from β-Pinene Derivatives

    Yiwen Li1,#, Hongyan Si1,#, Peng Wang1, Hai Luo1, Minggui Shen2, Xiaoping Rao3, Zhanqian Song2, Shibin Shang2, Zongde Wang1,*, Shengliang Liao1,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 45-56, 2024, DOI:10.32604/jrm.2023.031089

    Abstract Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component β-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of β-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these β-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus. The results showed that only compound 10o More > Graphic Abstract

    High-Value-Added Utilization of Turpentine: Screening of Anti-Influenza Virus Agents from <i>β</i>-Pinene Derivatives

  • Open Access


    Indian medicinal plants are effective in the treatment and management of COVID-19


    BIOCELL, Vol.47, No.4, pp. 677-695, 2023, DOI:10.32604/biocell.2023.026081

    Abstract Indian medicinal plants are referred to as the “nectar of life” owing to their phytochemicals and bioactive complexes that are beneficial in treating diseases. Coronavirus disease 2019 (COVID-19) is a global health issue without any proper medication. The indigenous plants of India can be exploited to control the precise signs of SARS-CoV-2. The Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) has advised routine usage of medicinal plants for COVID-19. Medicinal plants like Zingiber officinalis, Azadirachta indica, Ocimum sanctum, Nigella sativa, Withania somnifera, Curcuma longa, Piper nigrum, Allium sativum, Tinospora cordifolia, etc. have More >

  • Open Access


    Secondary antiviral metabolites from fungi with special reference to coronaviruses


    BIOCELL, Vol.46, No.8, pp. 1979-1988, 2022, DOI:10.32604/biocell.2022.019301

    Abstract Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various systems. Because of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals, viral contagions are amongst the most causative diseases affecting people worldwide. Fungi exemplify a massive source of bioactive molecules as, many fungal secondary metabolities like Oxoglyantrypine, Carneic acid F, Scedapin C, Asteltoxin E, Phomanolide, Norquinadoline A and Quinadoline B have antiviral activity. This review deals with how secondary metabolites of fungi can help in the war against More >

  • Open Access


    Investigation of SARS-CoV-2 Main Protease Potential Inhibitory Activities of Some Natural Antiviral Compounds Via Molecular Docking and Dynamics Approaches

    Nada M. Mostafa1,5,#, Muhammad I. Ismail2,#, Amr M. El-Araby3, Dina M. Bahgat1, Ahmed M. Elissawy1,5, Ahmed M. Mostafa4, Omayma A. Eldahshan1,5,*, Abdel Nasser B. Singab1,5,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 1089-1104, 2022, DOI:10.32604/phyton.2022.018239

    Abstract Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million individuals. The primary treatment is either supportive or symptomatic. Natural products have an important role in the development of various drugs. Thus, screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against coronaviruses. In the current study, an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents, (e.g.,… More >

  • Open Access


    Antimicrobial activities of three seaweeds extract against some human viral and bacterial pathogens


    BIOCELL, Vol.46, No.1, pp. 247-261, 2022, DOI:10.32604/biocell.2022.015966


    Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells by 57.1%, 85.7%, and 91.4%, respectively.

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  • Open Access


    Identification of Antimicrobial Peptides Using Chou’s 5 Step Rule

    Sharaf J. Malebary1, Yaser Daanial Khan2,*

    CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 2863-2881, 2021, DOI:10.32604/cmc.2021.015041

    Abstract With the advancement in cellular biology, the use of antimicrobial peptides (AMPs) against many drug-resistant pathogens has increased. AMPs have a broad range of activity and can work as antibacterial, antifungal, antiviral, and sometimes even as anticancer peptides. The traditional methods of distinguishing AMPs from non-AMPs are based only on wet-lab experiments. Such experiments are both time-consuming and expensive. With the recent development in bioinformatics more and more researchers are contributing their effort to apply computational models to such problems. This study proposes a prediction algorithm for classifying AMPs and distinguishing between AMPs and non-AMPs.… More >

  • Open Access


    Potential Inhibitory Effect of Vitamins Against COVID-19

    Kashaf Junaid1,*, Sumera Qasim2, Humaira Yasmeen3, Hasan Ejaz1, Abdullah Alsrhani1, Muhammad Ikram Ullah1, Fahad Ahmad4, Abdul Rehman5

    CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 707-714, 2021, DOI:10.32604/cmc.2020.012976

    Abstract Coronavirus disease 2019 (COVID-19) is a current pandemic that has affected more than 195 countries worldwide. In this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, when treatment strategies are not yet clear and vaccines are not available, vitamins are an excellent choice to protect against this viral infection. The rationale behind this study was to examine the inhibitory effect of vitamins B, C, and D against the main protease of SARSCoV-2 and angiotensin-converting enzyme 2 (ACE2), which have critical rolesin the immune system. Molecular docking, performed by using MOE-Dock of the Chemical Computing Group,… More >

  • Open Access


    Plant Derived Antiviral Products for Potential Treatment of COVID-19: A Review

    Rashid Iqbal Khan1,*, Mazhar Abbas1, Khurram Goraya2, Muhammad Zafar-ul-Hye3, Subhan Danish3

    Phyton-International Journal of Experimental Botany, Vol.89, No.3, pp. 438-452, 2020, DOI:10.32604/phyton.2020.010972

    Abstract COVID-19 caused by SARS-CoV-2 is declared global pandemic. The virus owing high resemblance with SARS-CoV and MERS-CoV has been placed in family of beta-coronavirus. However, transmission and infectivity rate of COVID-19 is quite higher as compared to other members of family. Effective management strategy with potential drug availability will break the virus transmission chain subsequently reduce the pressure on the healthcare system. Extensive research trials are underway to develop novel efficient therapeutics against SARS-CoV-2. In this review, we have discussed the origin and family of coronavirus, structure, genome and pathogenesis of virus SARS-CoV-2 inside human More >

  • Open Access


    In vitro antiviral activity and phytochemical screen in the extracts of peels from four species of tropical fruits collected in Merida Yucatan, Mexico

    Chel-Guerrero LD1, R Gómez-Cansino2, SL Gúzman-Gutierrez3, MG Campos-Lara4, E Saury-Duch1, F Díaz de León Sánchez5, R Reyes-Chilpa6, JA Mendoza-Espinoza7

    Phyton-International Journal of Experimental Botany, Vol.87, pp. 68-71, 2018, DOI:10.32604/phyton.2018.87.068

    Abstract The objective of this study was to investigate extracts from the peels of Annona squamosa L. (purple sugar apple), Annona reticulata L. (custard apple), Chrysophyllum cainito L. (green star apple), and Melicoccus bijugatus Jacq. (mamoncillo), as potential sources of anti-HIV-1 agents. Methanolic extracts from the peels of the aforementioned tropical fruits were obtained by maceration. Antiviral activity was evaluated through HIV-1 RT inhibition by extracts, using a non-radioactive immuno/colorimetric assay (Lenti RT Activity Assay, Cavidi Tech). Assay was performed according to the protocol provided by the manufacturer. Extracts from the peels of A. squamosa, A. reticulata, and C. cainito showed high More >

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