Open Access

ARTICLE

In vitro antiviral activity and phytochemical screen in the extracts of peels from four species of tropical fruits collected in Merida Yucatan, Mexico

Chel-Guerrero LD¹, R Gómez-Cansino², SL Gúzman-Gutierrez³, MG Campos-Lara⁴, E Saury-Duch¹, F Díaz de León Sánchez⁵, R Reyes-Chilpa⁶, JA Mendoza-Espinoza⁷

1 Laboratory of Instrumental Analysis, Instituto Tecnológico de Mérida.
2 Universidad Tecnológica de la Mixteca, Cátedra CONACyT.
3 Institute of Biomedical Research, Universidad Nacional Autónoma de México (UNAM), Cátedra CONACyT.
4 Hospital Infantil de México Dr. Federico Gómez.
5 Universidad Autónoma Metropolitana, Iztapalapa.
6 Institute of Chemistry, Universidad Nacional Autónoma de México (UNAM).
7 Program of Natural Products, Campus Casa Libertad, College of Sciences and Humanities, Universidad Autónoma de la Ciudad de México (UACM).

* Address correspondence to: Ricardo Reyes-Chilpa. e-mail: José Alberto Mendoza-Espinoza, e-mail: ;

Phyton-International Journal of Experimental Botany 2018, 87(all), 68-71. https://doi.org/10.32604/phyton.2018.87.068

Abstract

The objective of this study was to investigate extracts from the peels of Annona squamosa L. (purple sugar apple), Annona reticulata L. (custard apple), Chrysophyllum cainito L. (green star apple), and Melicoccus bijugatus Jacq. (mamoncillo), as potential sources of anti-HIV-1 agents. Methanolic extracts from the peels of the aforementioned tropical fruits were obtained by maceration. Antiviral activity was evaluated through HIV-1 RT inhibition by extracts, using a non-radioactive immuno/colorimetric assay (Lenti RT Activity Assay, Cavidi Tech). Assay was performed according to the protocol provided by the manufacturer. Extracts from the peels of A. squamosa, A. reticulata, and C. cainito showed high antiviral activity, with HIV-1 reverse transcriptase inhibition values of 96.45 ± 2.08%, 78.63 ± 0.97%, and 72.55 ± 2.26%, respectively. These results demonstrate that A. squamosa, A. reticulata, and C. cainito have significant antiviral activity in their peels and can therefore be regarded as potential sources of anti-HIV-1 agents.

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