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  • Open Access

    ARTICLE

    Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BPH/5 mouse model

    DANIELLA M. ADAMS1, KALIE F. BECKERS1, JULIET P. FLANAGAN1, VIVIANE C. L. GOMES1,#, CHIN-CHI LIU1, JENNY L. SONES1,2,*

    BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644

    Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57 ad lib controls beginning… More >

  • Open Access

    ARTICLE

    Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway

    ZICHEN SHAO1,2,#, CHUNG-YI CHEN3,#, XUZHOU CHEN1, HANWU CHEN1, MENGQIAO SU1,2, HUI SUN1,2, YIDAN LI1,2, BINGHUA TU1, ZITONG WANG1, CHI-MING LIU1,*

    BIOCELL, Vol.47, No.6, pp. 1389-1396, 2023, DOI:10.32604/biocell.2023.028222

    Abstract Background: Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. Methods: Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. The… More >

  • Open Access

    ARTICLE

    Person Re-Identification Using LBPH and K-Reciprocal Encoding

    V. Manimaran*, K. G. Srinivasagan

    Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 1109-1121, 2022, DOI:10.32604/iasc.2022.023145

    Abstract Individual re-identification proof (Re-ID) targets recovering an individual of interest across different non-covering cameras. With the recent development of technological algorithm and expanding request of intelligence video observation, it has acquired fundamentally expanded interest in the computer vision. Person re-identification is characterized as the issue of perceiving an individual caught in different occasions and additionally areas more than a few nonoverlapping camera sees, thinking about a huge arrangement of up-and-comers. This issue influences essentially the administration of disseminated, multiview observation frameworks, in which subjects should be followed across better places, either deduced or on-the-fly when they travel through various areas.… More >

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