Open Access iconOpen Access

ARTICLE

crossmark

Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway

ZICHEN SHAO1,2,#, CHUNG-YI CHEN3,#, XUZHOU CHEN1, HANWU CHEN1, MENGQIAO SU1,2, HUI SUN1,2, YIDAN LI1,2, BINGHUA TU1, ZITONG WANG1, CHI-MING LIU1,*

1 School of Medicine, Yichun University, Yichun, 336000, China
2 College of Chemistry and Bio-Engineering, Yichun University, Yichun, 336000, China
3 School of Medical and Health Sciences, Fooyin University, Kaohsiung, 83102, Taiwan

* Corresponding Author: CHI-MING LIU. Email: email
# These authors contributed equally to this work

BIOCELL 2023, 47(6), 1389-1396. https://doi.org/10.32604/biocell.2023.028222

Abstract

Background: Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and elderly men. Enlargement of the prostate causes lower urinary tract symptoms. Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. Methods: Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo. A prostatic stromal myofibroblast cell line (WPMY-1) was co-incubated with testosterone (1 µM) and different concentrations of capsaicin (10–100 µM) for 24 and 48 h. Capsaicin (10–100 µM) significantly inhibited testosterone-treated WPMY-1 cell growth at 48 h by MTT assay. The testosterone propionate (7.5 mg/kg)-induced BPH mouse model was used to examine the anti-proliferative effect of capsaicin. Treatment with capsaicin (10 mg/kg) for 14 days significantly attenuated prostatic hyperplasia. Finasteride was used as a positive control. Results: Capsaicin significantly decreased prostate weight and prostate index (prostate/body weight ratio) in BPH mice. The expression of 5α-reductase type II, androgen receptor (AR) and prostate specific antigen (PSA) protein expression and PSA serum were all significantly reduced in capsaicin-treated BPH mice. In addition, capsaicin also activated transient receptor potential vanilloid 1 mediated apoptosis and autophagy in BPH mice. Conclusion: These results demonstrate multiple positive effects of capsaicin in controlling prostate growth and suggest its therapeutic potential in the treatment of BPH.

Keywords


Cite This Article

APA Style
SHAO, Z., CHEN, C., CHEN, X., CHEN, H., SU, M. et al. (2023). Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway. BIOCELL, 47(6), 1389-1396. https://doi.org/10.32604/biocell.2023.028222
Vancouver Style
SHAO Z, CHEN C, CHEN X, CHEN H, SU M, SUN H, et al. Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway. BIOCELL . 2023;47(6):1389-1396 https://doi.org/10.32604/biocell.2023.028222
IEEE Style
Z. SHAO et al., "Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway," BIOCELL , vol. 47, no. 6, pp. 1389-1396. 2023. https://doi.org/10.32604/biocell.2023.028222



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 761

    View

  • 465

    Download

  • 0

    Like

Share Link