YAN ZHUANG1,#, CHUNLAN NING2,3,#, PENGFEI LIU4,#, YANPENG ZHAO5, YUE LI6, ZHENCHI MA6, LULING SHAN6, YINGZHE PIAO7, PENG ZHAO6,*, XUN JIN2,*
Oncology Research, Vol.30, No.6, pp. 289-300, 2022, DOI:10.32604/or.2022.028225
Abstract Aberrant activation of the WNT signaling pathway is a joint event in colorectal cancer (CRC), but the molecular
mechanism is still unclear. Recently, RNA-splicing factor LSM12 (like-Sm protein 12) is highly expressed in CRC tissues.
This study aimed to verify whether LSM12 is involved in regulating CRC progression via regulating the WNT signaling
pathway. Here, we found that LSM12 is highly expressed in CRC patient-derived tissues and cells. LSM12 is involved in
the proliferation, invasion, and apoptosis of CRC cells, similar to the function of WNT signaling in CRC. Furthermore,
protein interaction simulation and biochemical experiments proved that LSM12 directly… More >
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