Sami Alrabie^#,*, Ahmed Barnawi^#

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2481-2519, 2025, DOI:10.32604/cmes.2025.067977 - 31 August 2025

Abstract In the effort to enhance cardiovascular diagnostics, deep learning-based heart sound classification presents a promising solution. This research introduces a novel preprocessing method: iterative k-means clustering combined with silhouette score analysis, aimed at downsampling. This approach ensures optimal cluster formation and improves data quality for deep learning models. The process involves applying k-means clustering to the dataset, calculating the average silhouette score for each cluster, and selecting the cluster with the highest score. We evaluated this method using 10-fold cross-validation across various transfer learning models from different families and architectures. The evaluation was conducted on… More >

Siarhei A. Dabravolski^1,*, Michael I. Bukrinsky², Aleksandra S. Utkina³, Alessio L. Ravani⁴, Vasily N. Sukhorukov^5,6, Alexander N. Orekhov⁷

BIOCELL, Vol.49, No.6, pp. 931-959, 2025, DOI:10.32604/biocell.2025.062789 - 24 June 2025

Abstract Neutrophil extracellular traps (NET) have emerged as critical players in the pathogenesis of atherosclerosis and other cardiovascular diseases (CVD). These web-like structures, composed of DNA, histones, and granule proteins released by neutrophils, contribute significantly to both inflammation and thrombosis. This manuscript offers a comprehensive review of the recent literature on the involvement of NET in atherosclerosis, highlighting their interactions with various pathophysiological processes and their potential as biomarkers for CVD. Notably, the impact of radiation on NET formation is explored, emphasising how oxidative stress and inflammatory responses drive NET release, contributing to plaque instability. The… More >

Chih-Ta Yen^1,*, Jung-Ren Wong², Chia-Hsang Chang²

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 347-363, 2025, DOI:10.32604/cmc.2025.063389 - 09 June 2025

Abstract In its 2023 global health statistics, the World Health Organization noted that noncommunicable diseases (NCDs) remain the leading cause of disease burden worldwide, with cardiovascular diseases (CVDs) resulting in more deaths than the three other major NCDs combined. In this study, we developed a method that can comprehensively detect which CVDs are present in a patient. Specifically, we propose a multi-label classification method that utilizes photoplethysmography (PPG) signals and physiological characteristics from public datasets to classify four types of CVDs and related conditions: hypertension, diabetes, cerebral infarction, and cerebrovascular disease. Our approach to multi-disease classification… More >

Deema Mohammed Alsekait¹, Ahmed Younes Shdefat², Ayman Nabil³, Asif Nawaz^4,*, Muhammad Rizwan Rashid Rana⁴, Zohair Ahmed⁵, Hanaa Fathi⁶, Diaa Salama AbdElminaam^6,7,8

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3967-3990, 2024, DOI:10.32604/cmc.2024.054591 - 12 September 2024

Abstract Heart disease remains a leading cause of morbidity and mortality worldwide, highlighting the need for improved diagnostic methods. Traditional diagnostics face limitations such as reliance on single-modality data and vulnerability to apparatus faults, which can reduce accuracy, especially with poor-quality images. Additionally, these methods often require significant time and expertise, making them less accessible in resource-limited settings. Emerging technologies like artificial intelligence and machine learning offer promising solutions by integrating multi-modality data and enhancing diagnostic precision, ultimately improving patient outcomes and reducing healthcare costs. This study introduces Heart-Net, a multi-modal deep learning framework designed to… More >

YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB^*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056 - 09 April 2024

Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

B. Ramesh, Kuruva Lakshmanna^*

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2513-2528, 2023, DOI:10.32604/cmes.2023.028944 - 03 August 2023

Abstract Major chronic diseases such as Cardiovascular Disease (CVD), diabetes, and cancer impose a significant burden on people and healthcare systems around the globe. Recently, Deep Learning (DL) has shown great potential for the development of intelligent mobile Health (mHealth) interventions for chronic diseases that could revolutionize the delivery of health care anytime, anywhere. The aim of this study is to present a systematic review of studies that have used DL based on mHealth data for the diagnosis, prognosis, management, and treatment of major chronic diseases and advance our understanding of the progress made in this… More > Graphic Abstract

Wasif Akbar¹, Adbul Mannan², Qaisar Shaheen^3,*, Mohammad Hijji⁴, Muhammad Anwar⁵, Muhammad Ayaz⁶

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6269-6286, 2023, DOI:10.32604/cmc.2023.036141 - 29 April 2023

Abstract Machine Learning (ML) has changed clinical diagnostic procedures drastically. Especially in Cardiovascular Diseases (CVD), the use of ML is indispensable to reducing human errors. Enormous studies focused on disease prediction but depending on multiple parameters, further investigations are required to upgrade the clinical procedures. Multi-layered implementation of ML also called Deep Learning (DL) has unfolded new horizons in the field of clinical diagnostics. DL formulates reliable accuracy with big datasets but the reverse is the case with small datasets. This paper proposed a novel method that deals with the issue of less data dimensionality. Inspired… More >

Manjur Kolhar^*, Mohammed Misfer

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 529-542, 2023, DOI:10.32604/iasc.2023.030098 - 29 September 2022

Abstract Machine learning (ML) and cloud computing have now evolved to the point where they are able to be used effectively. Further improvement, however, is required when both of these technologies are combined to reap maximum benefits. A way of improving the system is by enabling healthcare workers to select appropriate machine learning algorithms for prediction and, secondly, by preserving the privacy of patient data so that it cannot be misused. The purpose of this paper is to combine these promising technologies to maintain the privacy of patient data during the disease prediction process. Treatment of… More >

Mohammad Reza Haghshenas¹, Mina Roshan Zamir¹, Mahboubeh Sadeghi¹, Mohammad Javad Fattahi¹, Kimia Mirshekari¹, Abbas Ghaderi^1,2,*

European Cytokine Network, Vol.33, No.3, pp. 54-69, 2022, DOI:10.1684/ecn.2022.0480

Abstract Interleukin-38 (IL-38) is the most recent member of the IL-1 family that acts as a natural inflammatory inhibitor by binding to cognate receptors, particularly the IL-36 receptor. In vitro, animal and human studies on autoimmune, metabolic, cardiovascular and allergic diseases, as well sepsis and respiratory viral infections, have shown that IL-38 exerts an anti-inflammatory activity by modulating the generation and function of inflammatory cytokines (e.g. IL-6, IL-8, IL-17 and IL-36) and regulating dendritic cells, M2 macrophages and regulatory T cells (Tregs). Accordingly, IL-38 may possess therapeutic potential for these types of diseases. IL-38 down-regulates CCR3+… More >

Fuad Ali Mohammed Al-Yarimi^*

Intelligent Automation & Soft Computing, Vol.32, No.3, pp. 1729-1742, 2022, DOI:10.32604/iasc.2022.022418 - 09 December 2021

Abstract Computer-aided arrhythmia prediction from ECG (electrocardiograms) is essential in clinical practices, which promises to reduce the mortality caused by inexperienced clinical practitioners. Moreover, computer-aided methods often succeed in the early detection of arrhythmia scope from electrocardiogram reports. Machine learning is the buzz of computer-aided clinical practices. Particularly, computer-aided arrhythmia prediction methods highly adopted machine learning methods. However, the high dimensionality in feature values considered for the machine learning models’ training phase often causes false alarming. This manuscript addressed the high dimensionality in the learning phase and proposed an (Ensemble Learning method for Arrhythmia Prediction) ELAP… More >