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    Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition


    BIOCELL, Vol.46, No.6, pp. 1357-1362, 2022, DOI:10.32604/biocell.2022.018471

    Abstract The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. More >

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