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Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition

MARIANO BIZZARRI*, PAOLA PONTECORVI

Department of Experimental Medicine, Systems Biology Group, Sapienza University of Rome, Rome, 00163, Italy

* Address correspondence to: Mariano Bizzarri, email

(This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(6), 1357-1362. https://doi.org/10.32604/biocell.2022.018471

Abstract

The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area of interest in cancer and developmental biology.

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APA Style
BIZZARRI, M., PONTECORVI, P. (2022). Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition. BIOCELL, 46(6), 1357-1362. https://doi.org/10.32604/biocell.2022.018471
Vancouver Style
BIZZARRI M, PONTECORVI P. Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition. BIOCELL . 2022;46(6):1357-1362 https://doi.org/10.32604/biocell.2022.018471
IEEE Style
M. BIZZARRI and P. PONTECORVI, "Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition," BIOCELL , vol. 46, no. 6, pp. 1357-1362. 2022. https://doi.org/10.32604/biocell.2022.018471



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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