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Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition


Department of Experimental Medicine, Systems Biology Group, Sapienza University of Rome, Rome, 00163, Italy

* Address correspondence to: Mariano Bizzarri, email

(This article belongs to this Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(6), 1357-1362.


The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton can be modified–both pharmacologically and/or through microenvironment-dependent changes–has become a major area of interest in cancer and developmental biology.


Cite This Article

BIZZARRI, M., PONTECORVI, P. (2022). Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition. BIOCELL, 46(6), 1357–1362.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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