Special Issue "Tumor Microenvironment and Cytoskeletal Dynamics"

Submission Deadline: 30 March 2022 (closed)
Guest Editors

Dr. Xiang Qin, School of Life Science and Technology, University of Electronic Science and Technology of China, China. qinxiang@uestc.edu.cn


The tumor microenvironment plays a key role in malignant tumor progression. As a place where tumor cells survive, the tumor microenvironment contains not only biochemical but biophysical elements. Tumor cells can sense the extracellular microenvironment, which in turn affects the intracellular behaviors. Cytoskeleton is a structure highly involved in pathological process following a series of complex cellular-biological events called invasion–metastasis cascades. Therefore, the interplay between the extracellular and intracellular tumor microenvironment as well as its underlying mechanisms remain to be fully elucidated.


This special issue aims to synthesize insights on biochemical and biophysical tumor microenvironment. We welcome submissions of original research articles, review papers, communications, perspectives, commentaries that cover the recent advances in all aspects of tumor microenvironment and cytoskeleton network.


Topic include but are not limited to the following:

 Biochemical and biophysical tumor microenvironment,

 Interplay between tumor cells and extracellular microenvironment,

 Intracellular signal transductions,

 Cytoskeletal dynamics,

 Nucleus deformation and repair,

 Tumor multidrug resistance

Tumor microenvironment, Migration, Cytoskeleton, Drug resistance, Intracellular force

Published Papers
  • Role of PTX3 and complement modulation in the tumor microenvironment
  • Abstract Pentraxin-3 (PTX3), the prototype of long pentraxins, seems to influence complement system (CS) modulation. PTX3 and CS sustain carcinogenesis, enriching tumor microenvironment (TME) with pro-inflammatory molecules promoting angiogenesis in prostate cancer (PC) and renal cell carcinoma (RCC). Furthermore, cancer cells overexpress complement regulatory proteins, such as CD46, CD55 and CD59, which negatively affect complement pathways for support cancer cells survival. This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment (TME). More
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  • The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis
  • Abstract Hepatic stellate cells (HSCs) are the primary effector cells in liver fibrosis. In the normal liver, HSCs serve as the primary vitamin A storage cells in the body and retain a “quiescent” phenotype. However, after liver injury, they transdifferentiate to an “activated” myofibroblast-like phenotype, which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix proteins. The result is a fibrotic, stiff, and dysfunctional liver. Therefore, understanding the molecular mechanisms that govern HSC function is essential for the development of anti-fibrotic medications. The actin cytoskeleton has emerged as a key component of the fibrogenic response in wound… More
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  • Expression analysis of OsSERK, OsLEC1 and OsWOX4 genes in rice (Oryza sativa L.) callus during somatic embryo development
  • Abstract Somatic embryogenesis is an asexual reproduction process that occurs in many plant species, including rice. This process contains several totipotency markers such as Somatic Embryogenesis Receptor-like Kinase (SERK), Leafy Cotyledon1 (LEC1) and WUSCHEL-Related Homeobox4 (WOX4) and also a helpful model for embryo development and clones and transformations. Here, we report the gene expression during somatic embryo development correlates with regeneration frequency in 14 Javanica rice (pigmented and non-pigmented) using modifified N6 media supplemented with Kinetin (2.0 mg/L) and NAA (1.0 mg/L). Although there have been advances in understanding the genetic basis of somatic embryogenesis in other varieties, rice is still… More
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  • Microenvironment promotes cytoskeleton remodeling and adaptive phenotypic transition
  • Abstract The cytoskeleton includes three main classes of networked filaments behaving as a coherent and complex structure that confers stability to cell shape while serving as sensor of internal/extracellular changes. Microenvironmental stimuli interfere with the non-linear dynamics that govern cytoskeleton architecture, namely by fostering symmetry breakings and transitions across different phenotypic states. Such process induces a wholecoherent adaptive response, involving the reprogramming of biochemical and gene-expression patterns. These characteristics are especially relevant during development, and in those conditions in which a deregulated crosstalk between cells and the stroma is at the core of the pathological process. Therefore, studying how the cytoskeleton… More
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  • Prognostic tumor microenvironment gene and the relationship with immune infiltration characteristics in metastatic breast cancer
  • Abstract The aim of this study was to reveal genes associated with breast cancer metastasis, to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment, and to screen for prognostic biomarkers. Gene expression data of breast cancer patients and their metastases were downloaded from the GEO, TCGA database. R language package was used to screen for differentially expressed genes, enrichment analysis of genes, PPI network construction, and also to elucidate key genes for diagnostic and prognostic survival. Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells. We screened 25 hub genes,… More
  •   Views:392       Downloads:312        Download PDF

  • ISG15 and ISGylation: Emergence in the cytoskeleton dynamic and tumor microenvironment
  • Abstract Cytoskeletal remodeling affects the shape, adhesion, and motility of cells. Cytoskeletal dynamics are modulated by matrix proteins, integrins, and several cytokines in the tumor microenvironment. In this scenario, signaling is activated by integrins and interferons, which can induce ISG15 gene expression. This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system. Furthermore, non-conjugated ISG15 acts as a cytokine-like protein. In this viewpoint, the interplay between free ISG15, protein ISGylation, and cytoskeletal dynamics in the tumor microenvironment is discussed. More
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  • Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?
  • Abstract Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin-modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity. More
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