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Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?

LUCÍA VELOZ1,2, SANTIAGO A. BOSCH1,3, GONZALO APARICIO1,2,*, FLAVIO R. ZOLESSI1,2,*

1 Sección Biología Celular, Facultad de Ciencias, Universidad de la República, Montevideo, CP 11400, Uruguay
2 Institut Pasteur de Montevideo, Montevideo, CP 11400, Uruguay
3 Sección Biofísica y Biología de Sistemas, Facultad de Ciencias, Universidad de la República, Montevideo, CP 11400, Uruguay

* Corresponding Authors:GONZALO APARICIO. Email: email; FLAVIO R. ZOLESSI. Email: email

(This article belongs to the Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(3), 639-644. https://doi.org/10.32604/biocell.2022.018798

Abstract

Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion). Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin-modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity.

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Cite This Article

APA Style
VELOZ, L., BOSCH, S.A., APARICIO, G., ZOLESSI, F.R. (2022). Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?. BIOCELL, 46(3), 639-644. https://doi.org/10.32604/biocell.2022.018798
Vancouver Style
VELOZ L, BOSCH SA, APARICIO G, ZOLESSI FR. Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?. BIOCELL . 2022;46(3):639-644 https://doi.org/10.32604/biocell.2022.018798
IEEE Style
L. VELOZ, S.A. BOSCH, G. APARICIO, and F.R. ZOLESSI "Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?," BIOCELL , vol. 46, no. 3, pp. 639-644. 2022. https://doi.org/10.32604/biocell.2022.018798



cc Copyright © 2022 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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