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Biomechanics of transendothelial migration by cancer cells

Université Grenoble Alpes, CNRS, LIPhy, Grenoble, 38000, France
* Corresponding Author: CLAUDE VERDIER. Email:
(This article belongs to this Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(11), 2381-2386.

Received 15 January 2022; Accepted 27 April 2022; Issue published 07 July 2022


Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their growth. In addition the formation of metastases is very difficult to understand, since it involves very complex physical mechanisms such as cellular interactions and cell rheology, which are flow-dependent. Previous studies investigated transendothelial migration using sophisticated techniques such as microfluidics, traction force microscopy (TFM) or Atomic Force Microscopy (AFM), combined with physical modeling. Here we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration.


Rheology; Deformation; Forces; Adhesion; Biophysics

Cite This Article

VERDIER, C. (2022). Biomechanics of transendothelial migration by cancer cells. BIOCELL, 46(11), 2381–2386.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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