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  • Open Access


    Biomechanics of transendothelial migration by cancer cells


    BIOCELL, Vol.46, No.11, pp. 2381-2386, 2022, DOI:10.32604/biocell.2022.021368

    Abstract Cancer metastasis is still a major social issue with limited knowledge of the formation of tumors and their growth. In addition the formation of metastases is very difficult to understand, since it involves very complex physical mechanisms such as cellular interactions and cell rheology, which are flow-dependent. Previous studies investigated transendothelial migration using sophisticated techniques such as microfluidics, traction force microscopy (TFM) or Atomic Force Microscopy (AFM), combined with physical modeling. Here we summarize recent results and suggest new ways to investigate the precise mechanisms used by cancer cells to undergo transendothelial migration. More >

  • Open Access


    Cell adhesion in renal tubular epithelial cells: Biochemistry, biophysics or both


    BIOCELL, Vol.46, No.4, pp. 937-940, 2022, DOI:10.32604/biocell.2022.018414

    Abstract Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and progression. However, these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix, as well as the biophysical and mechanical properties orchestrated by cytoskeletal, membrane and matrix components. To fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function, it is important to consider both biochemical and biophysical attributes of the system being investigated. In this short viewpoint we reflect on our experiences More >

  • Open Access


    Effect of Mechanical Forces on the Behavior of Dental Stem Cells: A Scoping Review of In-Vitro Studies

    Maryam Rezai Rad1, Sadra Mohaghegh2, Farnaz Kouhestani3, Saeed Reza Motamedian4,*

    Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 51-67, 2021, DOI:10.32604/mcb.2021.015136

    Abstract This article is a scoping review of the studies that assessed the effect of mechanical forces on the behavior of dental stem cells (DSCs). PubMed and Scopus searches were done for in-vitro studies evaluating the effect of tension, hydrostatic pressure (i.e., the pressure applied through an incompressible fluid), compression, simulated microgravity, and vibration on DSCs. The following factors were analyzed: osteogenic/odontogenic differentiation, proliferation, adhesion and migration. Articles were reviewed according to the Preferred Reporting Items for Systematic Reviews extension for scoping reviews (PRISMA-ScR) guideline. Included studies were evaluated based on the modified Consolidated Standards of Reporting… More >

  • Open Access


    Biophysical Properties and Motility of Human Dendritic Cells Deteriorated by Suppressive Cytokines Through Cytoskeleton Remodeling

    Zhu Zeng1,*, Zuquan Hu1, Qinni Zheng1, Xiaoli Xu1, Rong Dong1, Hui Xue1, Hui Yang1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 68-69, 2019, DOI:10.32604/mcb.2019.07085

    Abstract Dendritic cells (DCs) play a crucial role in initiating and amplifying both the innate and adaptive immune responses [1]. Clinically, the DCs-based immunotherapy against cancer is considered one of the most promising therapies to overcome cancers, but there are still many challenges need to be overcome [2]. The motility of DCs is especially crucial for migration of immature DCs into peripheral tissue and dynamic physical interaction between mature DCs and naive T cells in the secondary lymph node. This study focuses on the investigations of DCs at different differentiation stages and under various suppressive cytokines… More >

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