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ABSTRACT

Biophysical Properties and Motility of Human Dendritic Cells Deteriorated by Suppressive Cytokines Through Cytoskeleton Remodeling

Zhu Zeng1,*, Zuquan Hu1, Qinni Zheng1, Xiaoli Xu1, Rong Dong1, Hui Xue1, Hui Yang1
1 School of Basic medical Sciences / School of Biology & Engineering, Guizhou Medical University, Guizhou 550025, China.
* Corresponding Author: Zhu Zeng. Email: zengzhu100@sina.com.

Molecular & Cellular Biomechanics 2019, 16(Suppl.2), 68-69. https://doi.org/10.32604/mcb.2019.07085

Abstract

Dendritic cells (DCs) play a crucial role in initiating and amplifying both the innate and adaptive immune responses [1]. Clinically, the DCs-based immunotherapy against cancer is considered one of the most promising therapies to overcome cancers, but there are still many challenges need to be overcome [2]. The motility of DCs is especially crucial for migration of immature DCs into peripheral tissue and dynamic physical interaction between mature DCs and naive T cells in the secondary lymph node. This study focuses on the investigations of DCs at different differentiation stages and under various suppressive cytokines (VEGF, TGF-β1 and IL-10) conditioned microenvironments from the interdisciplinary viewpoints. The biophysical characteristics of cells can reflect their relationship between structures and functions [3-5]. The results showed that the DCs at different differentiation stages appear various biophysical characteristics, including the suppressive cytokines deteriorate the motilities and immune functions of DCs through derangement of biophysical characteristics and reorganization of F-actin cytoskeleton, moreover, these changes are closely correlated with the expression levels of some cytoskeleton-binding proteins [6-9]. It is significant for further understanding of the biological behaviors of DCs and how to enhance the clinical effectiveness of DCs-based immunotherapy against cancers.

Keywords

Dendritic cells; motility; immune function; suppressive cytokines; biophysics

Cite This Article

Zeng, Z., Hu, Z., Zheng, Q., Xu, X., Dong, R. et al. (2019). Biophysical Properties and Motility of Human Dendritic Cells Deteriorated by Suppressive Cytokines Through Cytoskeleton Remodeling. Molecular & Cellular Biomechanics, 16(Suppl.2), 68–69.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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