Open Access

VIEWPOINT

Ready to migrate? Reading cellular signs of migration in an epithelial to mesenchymal transition model

TAMARA FERNÁNDEZ-CALERO1,2,3,#, IGNACIO LÓPEZ1,#, MARCOS DAVYT1, CORA CHALAR1, RICARDO EHRLICH1,4, MÓNICA MARÍN1,*
1 Biochemistry-Molecular Biology, Faculty of Science, Universidad de la República, Montevideo, 11400, Uruguay
2 Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, 11400, Uruguay
3 Departamento de Ciencias Exactas y Naturales, Universidad Católica del Uruguay, Montevideo, 11600, Uruguay
4 Institut Pasteur de Montevideo, Montevideo, 11400, Uruguay
* Corresponding Author: MÓNICA MARÍN. Email:
(This article belongs to this Special Issue: Tumor Microenvironment and Cytoskeletal Dynamics)

BIOCELL 2022, 46(11), 2353-2356. https://doi.org/10.32604/biocell.2022.020966

Received 31 December 2021; Accepted 18 March 2022; Issue published 07 July 2022

Abstract

The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.

Keywords

EMT; Migration; Translation machinery; Metabolism

Cite This Article

FERNÁNDEZ-CALERO, T., LÓPEZ, I., DAVYT, M., CHALAR, C., EHRLICH, R. et al. (2022). Ready to migrate? Reading cellular signs of migration in an epithelial to mesenchymal transition model. BIOCELL, 46(11), 2353–2356.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 324

    View

  • 132

    Download

  • 0

    Like

Share Link

WeChat scan