Open Access

REVIEW

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

MONALISA MISHRA1,2,*, PUNYATOYA PANDA1, BEDANTA KUMAR BARIK1, AMRITA MONDAL1, MRUTUNJAYA PANDA1
1 Neural Developmental Biology Lab, Department of Life Science, NIT Rourkela, Rourkela, 769008, India
2 Centre for Nanomaterials, NIT Rourkela, Rourkela, 769008, India
* Corresponding Author: Monalisa Mishra,
(This article belongs to this Special Issue: Cellular and Molecular Toxicology in Reproductive and Developmental Biology)

BIOCELL 2023, 47(1), 51-69. https://doi.org/10.32604/biocell.2022.023392

Received 24 April 2022; Accepted 21 June 2022; Issue published 26 September 2022

Abstract

Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a delay in developmental time, defective growth, structural abnormality of many organs, including sensory organs, behavioral abnormalities, or death in the fetus stage. Numerous model organisms are employed to assess the effect of neurotoxicants. The current review summarizes several methods used to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster.

Keywords

Developmental cycle, Drug metabolism, Neurotoxicity, Neurotoxicants, Complex behavioral assay, Stress enzymes

Cite This Article

MISHRA, M., PANDA, P., BARIK, B. K., MONDAL, A., PANDA, M. (2023). Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds. BIOCELL, 47(1), 51–69.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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