Jiunn-Wei Wang^1,2,3, Wen-Hung Hsu^2,3,4, Fang-Jung Yu^2,3, Fu-Chen Kuo⁵, Chung-Jung Liu^3,6, Chao-Hung Kuo^1,2,3, Jaw-Yuan Wang^7,8, Ming-Hong Lin^9,*, Deng-Chyang Wu^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 3907-3922, 2025, DOI:10.32604/or.2025.070432 - 27 November 2025

Abstract Objectives: Colorectal adenomatous polyps frequently recur after removal and are precursors to colorectal cancer, highlighting the need for effective preventive strategies. This study evaluated the efficacy of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) in preventing colorectal adenoma recurrence in high-risk patients. Methods: We conducted a randomized, single-blind, two-year crossover trial in patients with a history of adenomatous polyps. Participants received CBM588 in either the first or second year, with the alternate year as observation, and underwent annual surveillance colonoscopies. Outcomes (adenoma recurrence and polyp counts) were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Results: A total… More >

Ranran Yang^1,2,3,#, Dan Yuan^2,#, Chaohan Liang^4,#, Siying Zhu⁴, Jie Huang², Yingqi Zhang⁴, Weiling He⁵, Qinghai Li^1,*, Hong Zhang^2,*

Oncology Research, Vol.33, No.12, pp. 3945-3971, 2025, DOI:10.32604/or.2025.064463 - 27 November 2025

Abstract Background: Colorectal cancer (CRC) is a predominant contributor to global cancer-associated mortality worldwide. Oxaliplatin (OXP), a foundational chemotherapeutic agent for CRC, often exhibits limited efficacy due to the emergence of drug resistance. Although endothelin-1 (EDN1) has been implicated in tumor drug resistance, its role in oxaliplatin resistance in CRC remains poorly defined. This work aimed to define how EDN1 contributes to oxaliplatin resistance and to explore its potential as a therapeutic target. Methods: Public genomic datasets were analyzed to confirm EDN1 upregulation in colorectal cancer (CRC) and its association with poor prognosis. EDN1 expression was… More >

Giovana Pinheiro Viana da Silva¹, Edilson Costa^1,*, Paulo Henrique Rosa Melo¹, Fernanda Pacheco de Almeida Prado Bortolheiro¹, Thaise Dantas², Flávio Ferreira da Silva Binotti¹, Carlos Eduardo da Silva Oliveira¹, Abimael Gomes da Silva¹

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3109-3123, 2025, DOI:10.32604/phyton.2025.070221 - 29 October 2025

Abstract Hancornia speciosa ‘Gomes’, commonly known as mangabeira, is a fruit-bearing tree native to Brazil that plays a crucial role in sustaining its native biome, restoring degraded areas, and improving the socio-environmental conditions of these regions. The use of colored materials and bioinputs can help improve the quality of seedling production of Hancornia speciosa. This study aimed to evaluate the use of colored seedling tubes and a Chlorella vulgaris-based bioinput in developing Hancornia speciosa seedlings. The experiment was conducted at the Mato Grosso do Sul State University (UEMS), in Cassilândia, MS, using a completely randomized design in a 5 ×… More >

Jun Li^1,#, Yang Chen^1,#, Zhijiao Hao², Zhiyong Zhang³, Jingyi Fan¹, Xiao Liu¹, Xueli Zhao³, Hongyan Zhang⁴, Chenpeng Wu^3,*

Oncology Research, Vol.33, No.11, pp. 3523-3541, 2025, DOI:10.32604/or.2025.067535 - 22 October 2025

Abstract Background: Radiation sensitive 23 homolog B (RAD23B), a DNA repair-related protein, plays a contributory role in the development of multiple malignancies. This study aimed to explore the role of RAD23B in promoting colorectal cancer (CRC) metastasis and to elucidate the underlying molecular mechanisms. Methods: RAD23B was overexpressed in CRC cell lines SW480 and HCT-8, with empty vectors serving as controls. Invasion, cell proliferation, and migration were assessed using CCK-8 and Transwell assays. A xenograft mouse model was used to evaluate metastatic potential in vivo. Immunoprecipitation-mass spectrometry (IP-MS) and transcriptomic analysis by RNA sequencing (RNA-seq) were performed… More >

Jun Li¹, Kangmin Yu¹, Zhiyong Chen¹, Dan Xing², Binshan Zha¹, Wentao Xie¹, Huan Ouyang¹, Changjun Yu^3,*

Oncology Research, Vol.33, No.11, pp. 3469-3492, 2025, DOI:10.32604/or.2025.066193 - 22 October 2025

Abstract Objectives: Colorectal cancer (CRC) remains a major contributor to global cancer mortality, ranking second worldwide for cancer-related deaths in 2022, and is characterized by marked heterogeneity in prognosis and therapeutic response. We sought to construct a machine-learning prognostic model based on a complement-related risk signature (CRRS) and to situate this signature within the CRC immune microenvironment. Methods: Transcriptomic profiles with matched clinical annotations from TCGA and GEO CRC cohorts were analyzed. Prognostic CRRS genes were screened using Cox proportional hazards modeling alongside machine-learning procedures. A random survival forest (RSF) predictor was trained and externally validated.… More >

Rodrigo Rafael da Silva^1,*, Gabriela Carvalho Maia de Queiroz¹, Amanda Cibele da Paz Sousa¹, Antônio Gustavo de Luna Souto¹, Francisco Hélio Alves de Andrade ², Francimar Maik da Silva Morais¹, Rita Magally Oliveira da Silva Marcelino¹, Fagner Nogueira Ferreira¹, Alex Alvares da Silva³, Maria Isabela Batista Clemente¹, Baltazar Cirino Junior¹, Wedson Aleff Oliveira da Silva¹, Mateus de Freitas Almeida dos Santos¹, José Francismar de Medeiros^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2797-2814, 2025, DOI:10.32604/phyton.2025.068089 - 30 September 2025

Abstract Due to its tolerance to water deficit and salinity, sorghum is considered a suitable crop for cultivation in regions affected by these stress conditions, enabling the efficient use of limited water resources. This study evaluated the resilience of the sweet sorghum cultivar BRS 506 under water deficit and salinity stress, focusing on water relations and yield performance in semiarid conditions. A randomized complete block design was employed in a 3 × 3 factorial arrangement with four replicates. Treatments consisted of three levels of irrigation water salinity (1.50, 3.75, and 6.00 dS m⁻¹) and three irrigation levels… More >

Zhong Ren^1,2,3,#, Shuiming Zhang^1,#, Yuzhi Fei¹, Zhu Chen³, Yue Zhao³, Xin Meng³, Hongfei Zhao^2,*, Jie Ren^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2927-2947, 2025, DOI:10.32604/phyton.2025.067310 - 30 September 2025

Abstract Acer paxii belongs to the evergreen species of Acer, but it exhibits a unique feature of reddish leaves in fall in subtropical regions. Although the association of AP2/ERF transcription factors with color change has been well-documented in prior research, molecular investigations focusing on AP2/ERF remain notably lacking in Acer paxii. This research focuses on performing an extensive genome-wide investigation to identify and characterize the AP2/ERF gene family in Acer paxii. As a result, 123 ApAP2/ERFs were obtained. Phylogenetic analyses categorized the ApAP2/ERF family members into 15 subfamilies. The evolutionary traits of the ApAP2/ERFs were investigated by analyzing their… More >

Saad Sadiq¹, Kashif Sultan¹, Muhammad Sheraz², Teong Chee Chuah^2,*, Muhammad Usman Hashmi³

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3945-3963, 2025, DOI:10.32604/cmc.2025.067538 - 23 September 2025

Abstract Vehicle recognition plays a vital role in intelligent transportation systems, law enforcement, access control, and security operations—domains that are becoming increasingly dynamic and complex. Despite advancements, most existing solutions remain siloed, addressing individual tasks such as vehicle make and model recognition (VMMR), automatic number plate recognition (ANPR), and color classification separately. This fragmented approach limits real-world efficiency, leading to slower processing, reduced accuracy, and increased operational costs, particularly in traffic monitoring and surveillance scenarios. To address these limitations, we present a unified framework that consolidates all three recognition tasks into a single, lightweight system. The More >

Gaurav Saxena¹, Kiran Napte², Neeraj Kumar Shukla^3,4, Sushma Parihar^5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2307-2323, 2025, DOI:10.32604/cmes.2025.067530 - 31 August 2025

Abstract The ill-posed character of haze or fog makes it difficult to remove from a single image. While most existing methods rely on a transmission map refined through depth estimation and assume a constant scattering coefficient, this assumption limits their effectiveness. In this paper, we propose an enhanced transmission map that incorporates spatially varying scattering information inherent in hazy images. To improve linearity, the model utilizes the ratio of the difference between intensity and saturation to their sum. Our approach also addresses critical issues such as edge preservation and color fidelity. In terms of qualitative as More >

Ni Tang^1,2,3,*, Chenchun Hao^1,2, Rong Qiu^1,2

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2551-2562, 2025, DOI:10.32604/phyton.2025.070556 - 29 August 2025

Abstract Supplemental lighting has emerged as a widely adopted technique in greenhouse cultivation to enhance product visibility and improve the flavor characteristics of Chinese bayberry (Myrica rubra) in the international market. While studies on lighting have predominantly focused on colorimetry, limited research has addressed the precise control of chromatic parameters and their effect on fruit quality. This study examined the effects of varying lighting conditions, specifically correlated color temperatures and illuminance, on the growth and quality of Chinese bayberry varieties “Black Charcoal” and “Dongkui” using a precision control system. The bayberry plants were exposed to a constant… More >