Kaidi Yin, Lili Deng, Wen Liu^*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.075185 - 21 May 2026

Abstract Objectives: Although claudin-1 (CLDN1) interacts with Cluster of Differentiation 81 (CD81) in various cell types, the specific mechanism underlying this interaction and its functional implications in colorectal cancer (CRC) cells remain poorly understood. This study outlines the regulatory role of CLDN1 in CRC cell tumorigenicity through its interaction with CD81, elucidating the underlying signaling cascade. Methods: Changes in the expression of CLDN1 and CD81, as well as their correlation with the survival of CRC patients, were analyzed using samples from The Cancer Genome Atlas database, the Kaplan‒Meier plotter database, and tissue microarrays. CLDN1 and CD81 were… More >

Sajid Ullah Khan^*

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.079440 - 08 May 2026

Abstract Healthcare, education, technological advancement, and farming are the key challenges facing developing countries, with agriculture unquestionably playing an important role in economic growth. Ensuring adequate food production is essential for citizens’ survival, as it is anticipated that efforts in this area would result in increased food productivity. A key approach to enhancing field productivity involves meticulous care of its components, starting with the production of crops. Wheat leaf rust poses a severe threat, particularly to young seedlings, constituting a significant fungal disease that can cause a 25% reduction in wheat productivity. To overcome these issues,… More >

Selma Kösa^*

Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.079055 - 28 April 2026

Abstract This study was conducted to determine the effects of paclobutrazol (PBZ) application methods and dosages on the growth, leaf, flower, and color characteristics of Silene compacta Fisch., a natural species with high potential for use as a seasonal bedding and potted ornamental plant in landscape design. The experiment was carried out under greenhouse conditions, where potted plants received a single PBZ application during the vegetative stage. The study was arranged in a completely randomized design with a 2 × 3 factorial structure. PBZ was applied either as a foliar spray or as a soil drench at… More >

Nevena Todorovic^1,#, Sara Bertorello^1,#, Giulia Nannini¹, Serena Pillozzi², Simonetta Bianchi³, Maria Raffaella Ambrosio⁴, Elena Niccolai¹, Simone Baldi¹, Amedeo Amedei^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076380 - 22 April 2026

Abstract Background: Cancer remains one of the leading global health challenges, with lung cancer (LC), breast cancer (BC), and colorectal cancer (CRC) among the most prevalent and deadly malignancies. The intratumoral microbiota (IM), a distinct microbial ecosystem within tumor tissues, has recently emerged as a potential modulator of carcinogenesis, immune responses, and metastatic progression. However, comparative cross-cancer analyses remain limited. Therefore, this study aimed to compare the IM across these cancer types, with particular emphasis on distinguishing metastatic from non-metastatic malignancies, to identify tumor-specific microbial signatures with potential relevance for biomarker discovery, patient stratification, and microbiota-informed… More >

Pengtao Hu¹, Junjie Sun¹, Jian Lu², Chunlei Ge³, Hanzhi Sun¹, Chengyu Lv^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076013 - 22 April 2026

Abstract Liver metastases from colorectal cancer (CRC) are a primary cause of poor patient prognosis, closely linked to the liver’s unique tumor microenvironment (TME). Compared to primary tumors, research on the TME of liver metastases remains insufficient. This review systematically summarizes recent advances in TME research concerning colorectal liver metastases (CRLM), emphasizing its organ-specific characteristics, pivotal role in tumor progression, and influence on treatment response. We delve into the intricate cellular components of the TME—including tumor-associated macrophages, cancer-associated fibroblasts, and myeloid-derived suppressor cells—and non-cellular constituents such as the extracellular matrix and soluble factors. Furthermore, we explore More >

Wei Xu^1,#, Yuanyuan Zhang^2,#, Yizhi Ge^2,*, Yesong Guo^2,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075314 - 22 April 2026

Abstract Objectives: Radio-resistance hinders the effectiveness of radiotherapy for treating colorectal cancer (CRC) patients. Metadherin (MTDH) is proposed to exert a pivotal role in resistance to radiotherapy in various malignancies. This study aims to investigate the precise impact of MTDH on CRC radio-resistance. Methods: Through a fusion of 14 machine learning algorithms and SHapley Additive exPlanations (SHAP) interpretability analysis, we pinpointed MTDH as a pivotal gene implicated in radio-resistance mechanisms. Subsequently, we investigated MTDH expression in CRC tissues using single-cell RNA sequencing data (scRNA-seq) and bulk transcriptomic data. MTDH level was also examined in tissues from… More >

Chanwoong Yoon^1,#, Euihyeon Na^2,#, Min Joo Choi¹, Sang-Pil Yoon^1,3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.074140 - 22 April 2026

Abstract Objective: Increased Src kinase activity is known to correlate with cancer progression and poor prognosis, indicating that Src plays a central role in cell migration and invasion. In this study, we investigated the effects of saracatinib, a Src kinase inhibitor, under anoikis-resistant conditions in colorectal cancer cells. Methods: Wild-type and 5-fluorouracil-resistance acquired SNU-C5 colorectal cancer cells were cultured in both monolayer and spheroid systems under fetal bovine serum (FBS) or growth factor (GF) supplemented conditions. Cell viability assay, flow cytometry, wound healing assay, spheroid formation and morphometric analysis, and Western blotting were performed using both… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.081286 - 23 March 2026

Abstract This article has no abstract. More >

Jiaxi Li^#, Deepak Iyer^#, Siming Sui, Zheng Huang, Ryan Wai-Yan Sin, Abraham Tak-Ka Man, Wai-Lun Law, Chi-Chung Foo^*, Lui Ng^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074981 - 23 March 2026

Abstract Objectives: Piwi-associated RNAs are small non-coding RNAs implicated in cancer, yet few have been characterized in colorectal cancer (CRC). This study aimed to identify a CRC-related piRNA and investigate its clinical relevance, biological function, and biomarker potential. Methods: Candidates were identified by reanalysis of small-RNA sequencing. piR-37524 was quantified by quantitative real-time polymerase chain reaction (qRT-PCR) in colorectal cancer tissues, matched adjacent non-tumor tissues, colorectal adenomas, liver metastases, and serum samples from patients and healthy controls. Clinicopathological correlations and diagnostic performance were evaluated. Functional assays included 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation, colony formation, and wound-healing migration… More >

Candela Cives-Losada^1,2, Cristiana Soldani², Michela Anna Polidoro², Barbara Franceschini², Ana Lleo^3,4, Marcello Di Martino^1,5, Matteo Donadon^1,5,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.074093 - 23 March 2026

Abstract Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality rates in affected patients. The tumor microenvironment (TME)—comprised of interacting endothelial, stromal, and immune cells—plays a critical role in creating a supportive niche for tumor cell colonization and immune evasion and, thus, the establishment of metastases. The liver’s intrinsic nature further facilitates the development of immune tolerance, mediated by regulatory T cells, myeloid-derived suppressor cells, and soluble factors such as anti-inflammatory cytokines, which together dampen antitumor immune responses. This immunosuppressive milieu More > Graphic Abstract