ELYN AMIELA SALLEH¹, YEONG YEH LEE², ANDEE DZULKARNAEN ZAKARIA³, NUR ASYILLA CHE JALIL⁴, MARAHAINI MUSA^1,*

BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More > Graphic Abstract

LIANLI NI^1,2,#, YUN YU^1,2,#, HAN LIN^1,2, WEISHAN ZHUGE², LU TAO², YIWEI SHEN², RI CUI^2,*, SHAOTANG LI^1,2,*

BIOCELL, Vol.47, No.10, pp. 2245-2254, 2023, DOI:10.32604/biocell.2023.030147

Abstract Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC… More >

Arslan Akram^1,2, Javed Rashid^2,3,4, Fahima Hajjej⁵, Sobia Yaqoob^1,6, Muhammad Hamid⁷, Asma Irshad⁸, Nadeem Sarwar^9,*

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 1081-1101, 2023, DOI:10.32604/cmc.2023.041558

Abstract Around one in eight women will be diagnosed with breast cancer at some time. Improved patient outcomes necessitate both early detection and an accurate diagnosis. Histological images are routinely utilized in the process of diagnosing breast cancer. Methods proposed in recent research only focus on classifying breast cancer on specific magnification levels. No study has focused on using a combined dataset with multiple magnification levels to classify breast cancer. A strategy for detecting breast cancer is provided in the context of this investigation. Histopathology image texture data is used with the wavelet transform in this technique. The proposed method comprises… More >

Raheem Ogla^1,*, Eman Shakar Mahmood¹, Rasha I. Ahmed¹, Abdul Monem S. Rahma²

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3075-3096, 2023, DOI:10.32604/cmc.2023.039818

Abstract The transmission of video content over a network raises various issues relating to copyright authenticity, ethics, legality, and privacy. The protection of copyrighted video content is a significant issue in the video industry, and it is essential to find effective solutions to prevent tampering and modification of digital video content during its transmission through digital media. However, there are still many unresolved challenges. This paper aims to address those challenges by proposing a new technique for detecting moving objects in digital videos, which can help prove the credibility of video content by detecting any fake objects inserted by hackers. The… More >

SUNG HEE LIM^1,#, HEE JIN CHO^1,2,3,#, KYOUNG-MEE KIM⁴, HO YEONG LIM¹, WON KI KANG¹, JEEYUN LEE¹, YOUNG SUK PARK¹, HEE CHEOL KIM^5,*, SEUNG TAE KIM^1,*

Oncology Research, Vol.31, No.6, pp. 855-866, 2023, DOI:10.32604/or.2023.030374

Abstract Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported. Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues. Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89… More >

Liping Hong, Enming He, Wenhui Zhang, Mingqiong Zheng, Jingwen Wu, Wenhua Wang^*

Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2785-2805, 2023, DOI:10.32604/phyton.2023.030928

Abstract Potato (Solanum tuberosum L.) is susceptible to enzymatic browning after fresh processing, resulting in color change and potential alteration in the nutritional quality. In this study, a popular potato cultivar, Feiwuruita, was used to profile the metabolites involved in color and nutritional quality changes in fresh shreds stored at 0 and 4 h at 25°C (designated CK and CK4H, respectively). The shreds turned brown within 4 h of storage. In all, 723 metabolites consisting 12 classes of compounds were detected in the samples, largely lipids, phenolic acids, alkaloids, amino acids and derivatives, flavonoids, organic acids, nucleotides and derivatives. Of these,… More >

LIJUN JIANG¹, WENMIN JI¹, YAJIE GONG², JIAJUN LI², JINCHUN LIU^1,*

BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516

Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p levels were determined using… More > Graphic Abstract

Doaa Sami Khafaga¹, Sarah M. Alhammad^1,*, Amal Magdi², Osama ElKomy², Nabil A. Lashin², Khalid M. Hosny²

Computer Systems Science and Engineering, Vol.47, No.2, pp. 1967-1986, 2023, DOI:10.32604/csse.2023.040345

Abstract Image authentication techniques have recently received a lot of attention for protecting images against unauthorized access. Due to the wide use of the Internet nowadays, the need to ensure data integrity and authentication increases. Many techniques, such as watermarking and encryption, are used for securing images transmitted via the Internet. The majority of watermarking systems are PC-based, but they are not very portable. Hardware-based watermarking methods need to be developed to accommodate real-time applications and provide portability. This paper presents hybrid data security techniques using a zero watermarking method to provide copyright protection for the transmitted color images using multi-channel… More >

Goma Tshivetta Christian Fersein Jorvialom^1,2, Lord Amoah^1,2,*

Journal of Quantum Computing, Vol.4, No.3, pp. 183-197, 2022, DOI:10.32604/jqc.2022.039913

Abstract Prior versions of reversible data hiding with contrast enhancement (RDHCE) algorithms strongly focused on enhancing the contrast of grayscale images. However, RDHCE has recently witnessed a rise in contrast enhancement algorithms concentrating on color images. This paper implies a method for color images that uses the RGB (red, green, and blue) color model and is based on bi-histogram shifting and image adjustment. Bi-histogram shifting is used to embed data and image adjustment to achieve contrast enhancement by adjusting the images resulting from each channel of the color images before combining them to generate the final enhanced image. Images are first… More >

Turki M. Alanazi^*

Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 1553-1568, 2023, DOI:10.32604/iasc.2023.039686

Abstract Image processing is becoming more popular because images are being used increasingly in medical diagnosis, biometric monitoring, and character recognition. But these images are frequently contaminated with noise, which can corrupt subsequent image processing stages. Therefore, in this paper, we propose a novel nonlinear filter for removing “salt and pepper” impulsive noise from a complex color image. The new filter is called the Modified Vector Directional Filter (MVDF). The suggested method is based on the traditional Vector Directional Filter (VDF). However, before the candidate pixel is processed by the VDF, the MVDF employs a threshold and the neighboring pixels of… More >