Stellar Choi¹, HeeAe Ko², KyungRok Bae³, HyunSook Lee², HaeJong Joo⁴, Woong Choi^5,*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 335-355, 2025, DOI:10.32604/cmc.2025.061243 - 26 March 2025

Abstract Previous research utilizing Cartoon Generative Adversarial Network (CartoonGAN) has encountered limitations in managing intricate outlines and accurately representing lighting effects, particularly in complex scenes requiring detailed shading and contrast. This paper presents a novel Enhanced Pixel Integration (EPI) technique designed to improve the visual quality of images generated by CartoonGAN. Rather than modifying the core model, the EPI approach employs post-processing adjustments that enhance images without significant computational overhead. In this method, images produced by CartoonGAN are converted from Red-Green-Blue (RGB) to Hue-Saturation-Value (HSV) format, allowing for precise adjustments in hue, saturation, and brightness, thereby… More >

JI-SU HAN¹, HYE-JIN BOO¹, JIN WON HYUN¹, HEESANG SONG², IN-YOUB CHANG³, SANG-PIL YOON^1,4,*

Oncology Research, Vol.33, No.4, pp. 873-884, 2025, DOI:10.32604/or.2024.052003 - 19 March 2025

Abstract Background: Chitosan oligosaccharide (COS) is the major degradation product of chitosan by enzymatic processes. COS, with complete water solubility, exerts significant biological effects, including anti-cancer activity. We investigated the anti-tumor effects of COS on colorectal cancer as effective therapeutic methods with low side effects are lacking. Methods: COS was obtained from low molecular weight chitosan by an enzymatic method and the anti-cancer effects were measured by cell viability assay, flow cytometry analysis, Western blotting, and xenograft. Results: COS suppressed the proliferation of SNU-C5 cells compared to other colorectal cancer cells, but higher concentrations were required in… More > Graphic Abstract

Xiuyun Liu¹, Jixia Sun², Feng Ming³, Minxiao Liu^2,*, Xinyu Wang², Yingjie Zhang^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 379-391, 2025, DOI:10.32604/phyton.2025.060726 - 06 March 2025

Abstract To study the main aroma components of Phalaenopsis orchid and their relationship with colors, 10 fragrant cultivars with different colors, like pink, rose, yellow, and purple, were used as samples in this experiment. Headspace-gas chromatography-mass spectrometry was used to determine the main components of floral fragrance and analyze the correlation between floral color and fragrance. The results showed that the main aroma components of the 10 fragrant cultivars of Phalaenopsis were alcohols, alkenes, esters, and benzene ring compounds, and the main aroma components of different cultivars were diverse. The main aroma components of yellow fragrant flowers… More >

Chang-Eui Hong¹, Su-Yun Lyu^2,*

BIOCELL, Vol.49, No.2, pp. 289-314, 2025, DOI:10.32604/biocell.2025.061334 - 28 February 2025

Abstract Objectives: Among cutaneous malignancies, melanoma stands out for its particularly aggressive nature, with therapeutic interventions becoming notably limited once the disease progresses. In this research, we investigate the tumor-suppressing capabilities of water-extracted Korean mistletoe (Viscum album var. coloratum) and its purified lectin component (V. album var. coloratum agglutinin, VCA) using two distinct mouse melanoma models: B16BL6 and B16F10 cell lines. Methods: The impact of water extract and VCA treatments on melanoma cells was assessed through multiple experimental approaches, examining cellular survival rates, programmed cell death pathways, multicaspase activity, and cell cycle distribution patterns. To elucidate the interconnections among… More >

Mudassir Khalil¹, Muhammad Imran Sharif^2,*, Ahmed Naeem³, Muhammad Umar Chaudhry¹, Hafiz Tayyab Rauf^4,*, Adham E. Ragab⁵

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 1461-1461, 2025, DOI:10.32604/cmc.2024.061589 - 03 January 2025

Abstract This article has no abstract. More >

Mehmet Karahan^*

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 777-798, 2025, DOI:10.32604/cmc.2024.059123 - 03 January 2025

Abstract Advances in software and hardware technologies have facilitated the production of quadrotor unmanned aerial vehicles (UAVs). Nowadays, people actively use quadrotor UAVs in essential missions such as search and rescue, counter-terrorism, firefighting, surveillance, and cargo transportation. While performing these tasks, quadrotors must operate in noisy environments. Therefore, a robust controller design that can control the altitude and attitude of the quadrotor in noisy environments is of great importance. Many researchers have focused only on white Gaussian noise in their studies, whereas researchers need to consider the effects of all colored noises during the operation of… More >

WEI ZHANG^1,3,#, WEICHENG WANG^1,#, RUI WANG¹, XIAO HAN¹, LIJUN ZHU¹, WENJIE GUO^2,*, YANHONG GU^1,*

Oncology Research, Vol.33, No.1, pp. 225-234, 2025, DOI:10.32604/or.2024.050047 - 20 December 2024

Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against tumors.… More > Graphic Abstract

YAJUN CAO^1,2,3,#, SHUANG YIN^1,2,#, YIDAN FANG⁴, JIEXIAN ZHOU^3,*, YOUTAN LIU^1,2,*

BIOCELL, Vol.48, No.12, pp. 1773-1780, 2024, DOI:10.32604/biocell.2024.056374 - 30 December 2024

Abstract Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work, we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-time PCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanism underlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressed cell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN), acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofol stimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) More >

ZEYIN LAI¹, HANGYUAN ZHAO¹, HONG DENG^1,2,*

BIOCELL, Vol.48, No.11, pp. 1569-1578, 2024, DOI:10.32604/biocell.2024.053983 - 07 November 2024

Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >

Bumsoo Kim¹, Wonseop Shin², Yonghoon Jung¹, Youngsup Park³, Sanghyun Seo^1,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2143-2164, 2024, DOI:10.32604/cmes.2024.056079 - 31 October 2024

Abstract Arbitrary style transfer aims to perceptually reflect the style of a reference image in artistic creations with visual aesthetics. Traditional style transfer models, particularly those using adaptive instance normalization (AdaIN) layer, rely on global statistics, which often fail to capture the spatially local color distribution, leading to outputs that lack variation despite geometric transformations. To address this, we introduce Patchified AdaIN, a color-inspired style transfer method that applies AdaIN to localized patches, utilizing local statistics to capture the spatial color distribution of the reference image. This approach enables enhanced color awareness in style transfer, adapting… More >