Xiuyun Liu¹, Jixia Sun², Feng Ming³, Minxiao Liu^2,*, Xinyu Wang², Yingjie Zhang^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 379-391, 2025, DOI:10.32604/phyton.2025.060726 - 06 March 2025

Abstract To study the main aroma components of Phalaenopsis orchid and their relationship with colors, 10 fragrant cultivars with different colors, like pink, rose, yellow, and purple, were used as samples in this experiment. Headspace-gas chromatography-mass spectrometry was used to determine the main components of floral fragrance and analyze the correlation between floral color and fragrance. The results showed that the main aroma components of the 10 fragrant cultivars of Phalaenopsis were alcohols, alkenes, esters, and benzene ring compounds, and the main aroma components of different cultivars were diverse. The main aroma components of yellow fragrant flowers… More >

Chang-Eui Hong¹, Su-Yun Lyu^2,*

BIOCELL, Vol.49, No.2, pp. 289-314, 2025, DOI:10.32604/biocell.2025.061334 - 28 February 2025

Abstract Objectives: Among cutaneous malignancies, melanoma stands out for its particularly aggressive nature, with therapeutic interventions becoming notably limited once the disease progresses. In this research, we investigate the tumor-suppressing capabilities of water-extracted Korean mistletoe (Viscum album var. coloratum) and its purified lectin component (V. album var. coloratum agglutinin, VCA) using two distinct mouse melanoma models: B16BL6 and B16F10 cell lines. Methods: The impact of water extract and VCA treatments on melanoma cells was assessed through multiple experimental approaches, examining cellular survival rates, programmed cell death pathways, multicaspase activity, and cell cycle distribution patterns. To elucidate the interconnections among… More >

Mudassir Khalil¹, Muhammad Imran Sharif^2,*, Ahmed Naeem³, Muhammad Umar Chaudhry¹, Hafiz Tayyab Rauf^4,*, Adham E. Ragab⁵

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 1461-1461, 2025, DOI:10.32604/cmc.2024.061589 - 03 January 2025

Abstract This article has no abstract. More >

Mehmet Karahan^*

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 777-798, 2025, DOI:10.32604/cmc.2024.059123 - 03 January 2025

Abstract Advances in software and hardware technologies have facilitated the production of quadrotor unmanned aerial vehicles (UAVs). Nowadays, people actively use quadrotor UAVs in essential missions such as search and rescue, counter-terrorism, firefighting, surveillance, and cargo transportation. While performing these tasks, quadrotors must operate in noisy environments. Therefore, a robust controller design that can control the altitude and attitude of the quadrotor in noisy environments is of great importance. Many researchers have focused only on white Gaussian noise in their studies, whereas researchers need to consider the effects of all colored noises during the operation of… More >

WEI ZHANG^1,3,#, WEICHENG WANG^1,#, RUI WANG¹, XIAO HAN¹, LIJUN ZHU¹, WENJIE GUO^2,*, YANHONG GU^1,*

Oncology Research, Vol.33, No.1, pp. 225-234, 2025, DOI:10.32604/or.2024.050047 - 20 December 2024

Abstract Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC. Methods and Materials: We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against tumors.… More > Graphic Abstract

YAJUN CAO^1,2,3,#, SHUANG YIN^1,2,#, YIDAN FANG⁴, JIEXIAN ZHOU^3,*, YOUTAN LIU^1,2,*

BIOCELL, Vol.48, No.12, pp. 1773-1780, 2024, DOI:10.32604/biocell.2024.056374 - 30 December 2024

Abstract Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work, we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-time PCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanism underlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressed cell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN), acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofol stimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) More >

ZEYIN LAI¹, HANGYUAN ZHAO¹, HONG DENG^1,2,*

BIOCELL, Vol.48, No.11, pp. 1569-1578, 2024, DOI:10.32604/biocell.2024.053983 - 07 November 2024

Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >

Bumsoo Kim¹, Wonseop Shin², Yonghoon Jung¹, Youngsup Park³, Sanghyun Seo^1,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2143-2164, 2024, DOI:10.32604/cmes.2024.056079 - 31 October 2024

Abstract Arbitrary style transfer aims to perceptually reflect the style of a reference image in artistic creations with visual aesthetics. Traditional style transfer models, particularly those using adaptive instance normalization (AdaIN) layer, rely on global statistics, which often fail to capture the spatially local color distribution, leading to outputs that lack variation despite geometric transformations. To address this, we introduce Patchified AdaIN, a color-inspired style transfer method that applies AdaIN to localized patches, utilizing local statistics to capture the spatial color distribution of the reference image. This approach enables enhanced color awareness in style transfer, adapting… More >

Xiaodong Shi^*, Tingyu Wang, Sui Ai, Jiasi Li

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2571-2581, 2024, DOI:10.32604/phyton.2024.056606 - 30 October 2024

Abstract Cotton rose (Hibiscus mutabilis) is a well-known ornamental plant that produces large flowers of vibrant colors. However, metabolites in H. mutabilis flowers with vibrant color have not been fully understood. By performing a combined analysis of metabolomics and transcriptomics data, we here explored mechanisms for the production of primary active compounds in this plant. Multivariate statistics unveiled differences in flavonoid metabolism between white and pink flowers, with pink flowers exhibiting a greater flavonoid abundance. The white-to-pink transition of cotton rose flowers may be attributed to pelargonidin-3-O-glucoside formation. On examining the expression of genes related to the structure More > Graphic Abstract

YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract