YUNG-SUNG YEH^1,2,3, HSIANG-LIN TSAI^4,5, YEN-CHENG CHEN^4,6, WEI-CHIH SU^4,6, PO-JUNG CHEN^4,6, TSUNG-KUN CHANG^4,6,7, CHING-CHUN LI⁴, CHING-WEN HUANG^4,5, JAW-YUAN WANG^{4,5,6,8,9,10,*}

Oncology Research, Vol.30, No.2, pp. 65-76, 2022, DOI:10.32604/or.2022.026659

Abstract The controversial outcomes in patients with metastatic colorectal cancer (mCRC) highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical results. The optimal treatment cycles in patients with mCRC for metastasectomy remain undefined. This retrospective study compared the efficacy, safety, and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such patients. Sixty-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April 2022. Twenty-eight patients received 6 cycles of chemotherapy/targeted therapy, whereas 36 patients received ≥7 cycles (median, 13; range, 7–20). Clinical outcomes, including response, progression-free survival (PFS), overall survival… More >

YUANYUAN HUANG^#, HONGMEI WU^#, RUYUAN LIU, SONG JIN, WEILAI XIANG, CHANG YANG, LI XU, XIAONIAN ZHU^*

BIOCELL, Vol.47, No.3, pp. 445-454, 2023, DOI:10.32604/biocell.2023.025880

Abstract The tripartite motif (TRIMs) protein family has E3 ubiquitin ligase activity among most of its members. They participate in multiple cellular processes and signaling pathways in living organisms, including cell cycle, growth, and metabolism, and mediate chromatin modification, transcriptional regulation, post-translational modification, and cellular autophagy. Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients. Here we summarize the biological roles of the TRIMs protein family in cancers. More >

MOHADESEH NEMATI¹, YOUSEF RASMI¹, JAFAR REZAIE^2,*

BIOCELL, Vol.47, No.3, pp. 455-464, 2023, DOI:10.32604/biocell.2023.025603

Abstract Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer death globally. Resistance to therapy is a challenge for CRC treatment. Mesenchymal stem cells (MSCs) have become one of the furthermost effective approaches for tumor treatment due to their specific feature; however, their therapeutic function is controversial. Recently, extracellular vesicles (EVs) derived from MSCs (MSCs-EVs) have attracted extensive research attention due to their promising role in CRC treatment. EVs are cell-derived vesicles that transfer different biomolecules between cells, contributing to intracellular communication. MSCs-EVs can suppress CRC by delivering therapeutic agents to tumor cells. Several studies… More >

Shengzhe Ma^1,#, Xiaoming Zhu^1,#, Cheng Xin^1,#, Fuao Cao¹, Mengnan Xu¹, Xiangling Han¹, Jinke Sui^3,*, Wenjun Chang^2,*, Wei Zhang^1,*

Oncologie, Vol.24, No.4, pp. 823-833, 2022, DOI:10.32604/oncologie.2022.025411

Abstract Background: Reticulocalbin 3 (RCN3) has been associated with several malignancies. However, its role in colorectal cancer (CRC) remains controversial. Thus, this study aimed to investigate the role of RCN3 in CRC prognosis. Methods: The clinical significance of RCN3 expression in CRC was evaluated in a large cohort of 483 patients. Normal tissues, carcinoma, para-carcinoma, adenoma, and metastatic tissues were evaluated by immunohistochemistry. We investigated the association between RCN3 expression and CRC occurrence in tumors and other tissues. Prognostic factors were also evaluated by Kaplan-Meier survival analysis and the Cox regression model. Results: RCN3 was significantly overexpressed in CRC and metastatic… More >

Yongsheng Hu^*, Liyong Nan

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6555-6571, 2023, DOI:10.32604/cmc.2023.036090

Abstract The generation method of the key stream and the structure of the algorithm determine the security of the cryptosystem. The classical chaotic map has simple dynamic behavior and few control parameters, so it is not suitable for modern cryptography. In this paper, we design a new 2D hyperchaotic system called 2D simple structure and complex dynamic behavior map (2D-SSCDB). The 2D-SSCDB has a simple structure but has complex dynamic behavior. The Lyapunov exponent verifies that the 2D-SSCDB has hyperchaotic behavior, and the parameter space in the hyperchaotic state is extensive and continuous. Trajectory analysis and some randomness tests verify that… More >

Mousa Alhajlah^*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5157-5172, 2023, DOI:10.32604/cmc.2023.033339

Abstract Underwater images degraded due to low contrast and visibility issues. Therefore, it is important to enhance the images and videos taken in the underwater environment before processing. Enhancement is a way to improve or increase image quality and to improve the contrast of degraded images. The original image or video which is captured through image processing devices needs to improve as there are various issues such as less light available, low resolution, and blurriness in underwater images caused by the normal camera. Various researchers have proposed different solutions to overcome these problems. Dark channel prior (DCP) is one of the… More >

Mahdi Sahlabadi, Ravie Chandren Muniyandi, Zarina Shukur, Faizan Qamar^*, Syed Hussain Ali Kazmi

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5777-5797, 2023, DOI:10.32604/cmc.2023.032504

Abstract This research recognizes the limitation and challenges of adapting and applying Process Mining as a powerful tool and technique in the Hypothetical Software Architecture (SA) Evaluation Framework with the features and factors of lightweightness. Process mining deals with the large-scale complexity of security and performance analysis, which are the goals of SA evaluation frameworks. As a result of these conjectures, all Process Mining researches in the realm of SA are thoroughly reviewed, and nine challenges for Process Mining Adaption are recognized. Process mining is embedded in the framework and to boost the quality of the SA model for further analysis,… More >

Xue Song^1,2, Cun Liu², Jingying Wang^1,*, Xinglian Yang¹, Mingrui Li¹

Molecular & Cellular Biomechanics, Vol.19, No.4, pp. 209-219, 2022, DOI:10.32604/mcb.2022.026082

Abstract The umbilical cord is a vital structure between the fetus and placenta for the growth and well-being of the fetus. Although the umbilical cord may be the only organ that dies at the beginning of life, it is one of the most important parts of the feta-placental unit and plays a role in determining how life begins. In general, the prenatal examination of the umbilical cord is limited to the observation of the number of vessels and the evaluation of umbilical artery blood flow parameters. Pathologists have done more research on the morphological characteristics of the umbilical cord and linked… More >

HuangJing Yu¹, Jinming Qiu¹, Ning Cao^2,*, Russell Higgs²

Computer Systems Science and Engineering, Vol.45, No.3, pp. 3181-3193, 2023, DOI:10.32604/csse.2023.030985

Abstract Aiming at the dynamics and uncertainties of natural colors affected by the natural environment, a color P-law generation model based on the natural environment is proposed to develop algorithms and to provide a theoretical basis for plant dynamic color simulation and color sensor data transmission. Based on the HSL (Hue, Saturation, Lightness) color solid, the proposed method uses the function P-set to provide a color P-law generation model and an algorithm of the Dynamic Colors System (DCS), establishing the DCS modeling theory of the natural environment and the color P-reasoning simulation based on the HSL color solid. The experimental results… More >

S. Lavanya^1,*, N. M. Saravanakumar²

Computer Systems Science and Engineering, Vol.45, No.3, pp. 2869-2883, 2023, DOI:10.32604/csse.2023.029040

Abstract Many cutting-edge methods are now possible in real-time commercial settings and are growing in popularity on cloud platforms. By incorporating new, cutting-edge technologies to a larger extent without using more infrastructures, the information technology platform is anticipating a completely new level of development. The following concepts are proposed in this research paper: 1) A reliable authentication method Data replication that is optimised; graph-based data encryption and packing colouring in Redundant Array of Independent Disks (RAID) storage. At the data centre, data is encrypted using crypto keys called Key Streams. These keys are produced using the packing colouring method in the… More >