Open Access
ARTICLE
RCN3 Expression Indicates Prognosis in Colorectal Cancers
1
Department of Colorectal Surgery, Changhai Hospital, Shanghai, 200433, China
2
Department of Environmental Health, Naval Medical University, Shanghai, 200433, China
3
Jiahui International Cancer Center, Jiahui International Hospital, Shanghai, 200433, China
* Corresponding Authors: Jinke Sui. Email: ; Wenjun Chang. Email:
; Wei Zhang. Email:
# Contributed equally to this work
Oncologie 2022, 24(4), 823-833. https://doi.org/10.32604/oncologie.2022.025411
Received 10 July 2022; Accepted 22 September 2022; Issue published 31 December 2022
Abstract
Background: Reticulocalbin 3 (RCN3) has been associated with several malignancies. However, its role in colorectal cancer (CRC) remains controversial. Thus, this study aimed to investigate the role of RCN3 in CRC prognosis. Methods: The clinical significance of RCN3 expression in CRC was evaluated in a large cohort of 483 patients. Normal tissues, carcinoma, para-carcinoma, adenoma, and metastatic tissues were evaluated by immunohistochemistry. We investigated the association between RCN3 expression and CRC occurrence in tumors and other tissues. Prognostic factors were also evaluated by Kaplan-Meier survival analysis and the Cox regression model. Results: RCN3 was significantly overexpressed in CRC and metastatic tissues. Patients with high RCN3 expression had shorter disease-free survival than those with low RCN3 expression. Multivariate Cox regression analysis showed a risk ratio HR], 0.607; confidence interval [CI], 0.362–1.016; p < 0.05 after adjusting for other prognostic factors. HighRCN3 expression was also associated with a worse chemotherapeutic response in the colon (p < 0.01) or rectal (p < 0.05) cancer patients who received adjuvant chemotherapy. Conclusion: RCN3 expression level is an independent risk factor and serves as a prognostic biomarker for CRC. High RCN3 expression predicts poor prognosis and chemotherapeutic response.Keywords
Cite This Article
Ma, S., Zhu, X., Xin, C., Cao, F., Xu, M. et al. (2022). RCN3 Expression Indicates Prognosis in Colorectal Cancers. Oncologie, 24(4), 823–833.