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RCN3 Expression Indicates Prognosis in Colorectal Cancers

Shengzhe Ma1,#, Xiaoming Zhu1,#, Cheng Xin1,#, Fuao Cao1, Mengnan Xu1, Xiangling Han1, Jinke Sui3,*, Wenjun Chang2,*, Wei Zhang1,*

1 Department of Colorectal Surgery, Changhai Hospital, Shanghai, 200433, China
2 Department of Environmental Health, Naval Medical University, Shanghai, 200433, China
3 Jiahui International Cancer Center, Jiahui International Hospital, Shanghai, 200433, China

* Corresponding Authors: Jinke Sui. Email: email; Wenjun Chang. Email: email; Wei Zhang. Email: email
# Contributed equally to this work

Oncologie 2022, 24(4), 823-833.


Background: Reticulocalbin 3 (RCN3) has been associated with several malignancies. However, its role in colorectal cancer (CRC) remains controversial. Thus, this study aimed to investigate the role of RCN3 in CRC prognosis. Methods: The clinical significance of RCN3 expression in CRC was evaluated in a large cohort of 483 patients. Normal tissues, carcinoma, para-carcinoma, adenoma, and metastatic tissues were evaluated by immunohistochemistry. We investigated the association between RCN3 expression and CRC occurrence in tumors and other tissues. Prognostic factors were also evaluated by Kaplan-Meier survival analysis and the Cox regression model. Results: RCN3 was significantly overexpressed in CRC and metastatic tissues. Patients with high RCN3 expression had shorter disease-free survival than those with low RCN3 expression. Multivariate Cox regression analysis showed a risk ratio HR], 0.607; confidence interval [CI], 0.362–1.016; p < 0.05 after adjusting for other prognostic factors. HighRCN3 expression was also associated with a worse chemotherapeutic response in the colon (p < 0.01) or rectal (p < 0.05) cancer patients who received adjuvant chemotherapy. Conclusion: RCN3 expression level is an independent risk factor and serves as a prognostic biomarker for CRC. High RCN3 expression predicts poor prognosis and chemotherapeutic response.


Cite This Article

APA Style
Ma, S., Zhu, X., Xin, C., Cao, F., Xu, M. et al. (2022). RCN3 expression indicates prognosis in colorectal cancers. Oncologie, 24(4), 823-833.
Vancouver Style
Ma S, Zhu X, Xin C, Cao F, Xu M, Han X, et al. RCN3 expression indicates prognosis in colorectal cancers. Oncologie . 2022;24(4):823-833
IEEE Style
S. Ma et al., "RCN3 Expression Indicates Prognosis in Colorectal Cancers," Oncologie , vol. 24, no. 4, pp. 823-833. 2022.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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