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  • Open Access


    Exogenous dendritic cells aggravate atherosclerosis via P-selectin/ PSGL-1 pathway


    BIOCELL, Vol.44, No.2, pp. 225-236, 2020, DOI:10.32604/biocell.2020.08714

    Abstract Studies have found that a large number of inflammatory cells, P-selectin, and mature dendritic cells (DCs) are expressed in the damaged and shoulder parts of atherosclerotic plaque, which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of atherosclerosis. However, it is unclear how the above factors interact in this setting. In this study, we investigated the role of P-selectin and its receptor, P-selectin glycoprotein ligand (PSGL)-1 in atherosclerosis, with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1 + DCs group,… More >

  • Open Access


    Biophysical Properties and Motility of Human Dendritic Cells Deteriorated by Suppressive Cytokines Through Cytoskeleton Remodeling

    Zhu Zeng1,*, Zuquan Hu1, Qinni Zheng1, Xiaoli Xu1, Rong Dong1, Hui Xue1, Hui Yang1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 68-69, 2019, DOI:10.32604/mcb.2019.07085

    Abstract Dendritic cells (DCs) play a crucial role in initiating and amplifying both the innate and adaptive immune responses [1]. Clinically, the DCs-based immunotherapy against cancer is considered one of the most promising therapies to overcome cancers, but there are still many challenges need to be overcome [2]. The motility of DCs is especially crucial for migration of immature DCs into peripheral tissue and dynamic physical interaction between mature DCs and naive T cells in the secondary lymph node. This study focuses on the investigations of DCs at different differentiation stages and under various suppressive cytokines (VEGF, TGF-β1 and IL-10) conditioned… More >

  • Open Access


    The Dendritic Cells’ Immunological Behaviors Modulated by the Spatial Confinements of Deposited Fibrin Matrix

    Wenhui Hu1, Yun Wang1, Jin Chen1, Yonggang Song1, Jinhua Long1, Zhu Zeng1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 67-67, 2019, DOI:10.32604/mcb.2019.07083

    Abstract The responses of dendritic cells (DCs) to the mechanical microenvironment caused by implanted materials are highly correlated to the host immune responses and largely determines the outcome of tissue regeneration [1,2]. In the early stage of the inflammations following injury or implantation, a large amount of fibrin would deposit around the implanted materials and form a microporous fibrous-liked network structure, which can provide mechanical microenvironment with different spatial confinement in dimensions for following recruited DCs. Herein, we have established a useful model by salmon fibrin to mimic the deposited fibrin matrix and found that DCs cultured on or in fibrin… More >

  • Open Access


    Biomechanical Characteristics Closely Related with Immune Functions of Dendritic Cells

    Fuzhou Tang1, Jin Chen1, Shichao Zhang1, Zuquan Hu1, Lina Liu1, Long Li1, Yan Ouyang1, Zhu Zeng1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 40-41, 2019, DOI:10.32604/mcb.2019.07082

    Abstract As potent antigen presenting cells, dendritic cells (DCs) are utilized to deliver the signals essential for the initiation of immune responses. The motility of DCs is crucial for migration of immature DCs (imDCs) in peripheral tissue and the interaction between mature DCs (mDCs) and naïve T cells in the secondary lymph node. From biomechanical viewpoint, the deformability of cells is necessary for their motility. Deformation of cells can be divided into active deformation (e.g. chemotaxis) and passive deformation (e.g. migration under shear stress of blood flow). However, there is no detailed study on the deformability of DCs including imDCs and… More >

  • Open Access


    Transforming Growth Factor-β1 Remodels the Cytoskeleton Organization of Mature Dendritic Cells via Smad2/3 Signaling Pathway

    Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 21-36, 2018, DOI:10.3970/mcb.2018.015.021

    Abstract Dendritic cells (DCs) are the most potent professional antigen presenting cells as now known, which play critical roles in the initiation, programming and regulation of the immune response. Transforming growth factor-β1 (TGF-β1), one of the major suppressive cytokines in tumor microenvironment, can deteriorate the biomechanical characteristics and motility of mature dendritic cells (mDCs),but the underlying molecular mechanisms are not well defined. In this study, the effects of TGF-β1 on the motilities and T cell priming capabilities of mDCs as well as the molecular regulatory mechanisms were investigated. The results showed that the cytoskeleton (F-actin) organizations of mDCs were abnormally remodeled… More >

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