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  • Open Access

    REVIEW

    Immunotherapy in gastric cancer—A systematic review

    MARTA SANTOS1, DIANA MARTINS1,2,3,4, FERNANDO MENDES1,2,3,4,5,*

    Oncology Research, Vol.33, No.2, pp. 263-281, 2025, DOI:10.32604/or.2024.052207 - 16 January 2025

    Abstract Background: Gastric Cancer (GC) is the 5th most prevalent and 4th most deadly neoplasm globally. Immunotherapy has emerged as a promising treatment approach in GC, potentially improving positive clinical outcomes while addressing the limitations of conventional therapies. GC immunotherapy modalities consist of adoptive cell therapy (ACT), cancer vaccines, and immune checkpoint inhibitors (ICI). Objectives: This systematic review aims to provide an overview of the advances in immune-based therapeutic approaches in GC, highlighting the potential of this therapy as a strategy for GC treatment. Methods: Key studies investigating several immunotherapeutic agents and combination therapies were searched in… More > Graphic Abstract

    Immunotherapy in gastric cancer—A systematic review

  • Open Access

    ARTICLE

    Data-Driven Method for Predicting Remaining Useful Life of Bearings Based on Multi-Layer Perception Neural Network and Bidirectional Long Short-Term Memory Network

    Yongfeng Tai1, Xingyu Yan2, Xiangyi Geng3, Lin Mu4, Mingshun Jiang2, Faye Zhang2,*

    Structural Durability & Health Monitoring, Vol.19, No.2, pp. 365-383, 2025, DOI:10.32604/sdhm.2024.053998 - 15 January 2025

    Abstract The remaining useful life prediction of rolling bearing is vital in safety and reliability guarantee. In engineering scenarios, only a small amount of bearing performance degradation data can be obtained through accelerated life testing. In the absence of lifetime data, the hidden long-term correlation between performance degradation data is challenging to mine effectively, which is the main factor that restricts the prediction precision and engineering application of the residual life prediction method. To address this problem, a novel method based on the multi-layer perception neural network and bidirectional long short-term memory network is proposed. Firstly,… More >

  • Open Access

    ARTICLE

    Internet of Things Software Engineering Model Validation Using Knowledge-Based Semantic Learning

    Mahmood Alsaadi, Mohammed E. Seno*, Mohammed I. Khalaf

    Intelligent Automation & Soft Computing, Vol.40, pp. 29-52, 2025, DOI:10.32604/iasc.2024.060390 - 10 January 2025

    Abstract The agility of Internet of Things (IoT) software engineering is benchmarked based on its systematic insights for wide application support infrastructure developments. Such developments are focused on reducing the interfacing complexity with heterogeneous devices through applications. To handle the interfacing complexity problem, this article introduces a Semantic Interfacing Obscuration Model (SIOM) for IoT software-engineered platforms. The interfacing obscuration between heterogeneous devices and application interfaces from the testing to real-time validations is accounted for in this model. Based on the level of obscuration between the infrastructure hardware to the end-user software, the modifications through device replacement, More >

  • Open Access

    ARTICLE

    LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

    Yiqing Lu1, Liutao Zhao2,*, Qiankun Zhao3

    CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 1401-1416, 2025, DOI:10.32604/cmc.2024.058757 - 03 January 2025

    Abstract Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental factors. These vehicles are crucial in various fields, including environmental science research, ecological and environmental monitoring projects, disaster response, and emergency management. A key method employed in these vehicles for achieving high-precision positioning is LiDAR (lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping (SLAM). However, maintaining high-precision localization in complex scenarios, such as degraded environments or when dynamic objects are present, remains a significant challenge. To address this issue, we integrate both semantic and… More >

  • Open Access

    REVIEW

    Review of Techniques for Integrating Security in Software Development Lifecycle

    Hassan Saeed1, Imran Shafi1, Jamil Ahmad2, Adnan Ahmed Khan3, Tahir Khurshaid4,*, Imran Ashraf5,*

    CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 139-172, 2025, DOI:10.32604/cmc.2024.057587 - 03 January 2025

    Abstract Software-related security aspects are a growing and legitimate concern, especially with 5G data available just at our palms. To conduct research in this field, periodic comparative analysis is needed with the new techniques coming up rapidly. The purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle (SDLC) by analyzing the articles published in the last two decades and to propose a way forward. This review follows Kitchenham’s review protocol. The review has been divided into three main stages including planning, execution, and analysis.… More >

  • Open Access

    ARTICLE

    Joint Estimation of SOH and RUL for Lithium-Ion Batteries Based on Improved Twin Support Vector Machineh

    Liyao Yang1, Hongyan Ma1,2,3,*, Yingda Zhang1, Wei He1

    Energy Engineering, Vol.122, No.1, pp. 243-264, 2025, DOI:10.32604/ee.2024.057500 - 27 December 2024

    Abstract Accurately estimating the State of Health (SOH) and Remaining Useful Life (RUL) of lithium-ion batteries (LIBs) is crucial for the continuous and stable operation of battery management systems. However, due to the complex internal chemical systems of LIBs and the nonlinear degradation of their performance, direct measurement of SOH and RUL is challenging. To address these issues, the Twin Support Vector Machine (TWSVM) method is proposed to predict SOH and RUL. Initially, the constant current charging time of the lithium battery is extracted as a health indicator (HI), decomposed using Variational Modal Decomposition (VMD), and… More >

  • Open Access

    ARTICLE

    Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

    Jie Lin*, Hongchi Shen, Tingting Pei, Yan Wu

    Energy Engineering, Vol.122, No.1, pp. 331-347, 2025, DOI:10.32604/ee.2024.055611 - 27 December 2024

    Abstract Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unit power generation costs. The service life of these modules directly affects these costs. Over time, the performance of PV modules gradually declines due to internal degradation and external environmental factors. This cumulative degradation impacts the overall reliability of photovoltaic power generation. This study addresses the complex degradation process of PV modules by developing a two-stage Wiener process model. This approach accounts for the distinct phases of degradation resulting from module aging and environmental influences. A power degradation model based on the More > Graphic Abstract

    Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

  • Open Access

    ARTICLE

    Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

    Shiqian Wang1, Bo Liu1, Yuanpeng Hua1, Qiuyan Li1, Binhua Tang2,*, Jianshu Zhou2, Yue Xiang2

    Energy Engineering, Vol.122, No.1, pp. 129-152, 2025, DOI:10.32604/ee.2024.054867 - 27 December 2024

    Abstract This paper introduces a method for modeling the entire aggregated electric vehicle (EV) charging process and analyzing its dispatchable capabilities. The methodology involves developing a model for aggregated EV charging at the charging station level, estimating its physical dispatchable capability, determining its economic dispatchable capability under economic incentives, modeling its participation in the grid, and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability. The results indicate that using economic dispatchable capability reduces charging prices by 9.7% compared to physical dispatchable capability and 9.3% compared to disorderly More >

  • Open Access

    ARTICLE

    Semantic Segmentation of Lumbar Vertebrae Using Meijering U-Net (MU-Net) on Spine Magnetic Resonance Images

    Lakshmi S V V1, Shiloah Elizabeth Darmanayagam1,*, Sunil Retmin Raj Cyril2

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.1, pp. 733-757, 2025, DOI:10.32604/cmes.2024.056424 - 17 December 2024

    Abstract Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people everywhere. Due to its ability to produce a detailed view of the soft tissues, including the spinal cord, nerves, intervertebral discs, and vertebrae, Magnetic Resonance Imaging is thought to be the most effective method for imaging the spine. The semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar diseases. It is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of… More >

  • Open Access

    ARTICLE

    Multi-Step Clustering of Smart Meters Time Series: Application to Demand Flexibility Characterization of SME Customers

    Santiago Bañales1,2,*, Raquel Dormido1, Natividad Duro1

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.1, pp. 869-907, 2025, DOI:10.32604/cmes.2024.054946 - 17 December 2024

    Abstract Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens’ participation in the energy transition. This study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time horizons. Smart meter data is split between daily and hourly normalized time series to assess monthly, weekly, daily, and hourly seasonality patterns separately. The dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series… More > Graphic Abstract

    Multi-Step Clustering of Smart Meters Time Series: Application to Demand Flexibility Characterization of SME Customers

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